Scientific Publications

Discover our peer-reviewed research, congress proceedings, and scientific insights across therapeutic areas.

Title	Year	Type	Event	Journal	Therapeutic Area	Citation
Global Age-Related Seroprevalence for Adeno-Associated Virus Serotype 9 Immunoglobulin G	2026	Publication		Mol Ther Advances	Neurology	Christophe Lo Bianco, Chien-Wei Chen, Rienk E. Jeeninga, Eveline E. Vietsch, Rudolf W. van Olden. Global age-related seroprevalence for adeno-associated virus serotype 9 immunoglobulin G. Mol Ther Advances. 2026 March 12;34(1):1201662.
The Causes of Errors in Clinical Reasoning: Cognitive Biases, Knowledge Deficits, and Dual Process Thinking	2026	Publication		Blood Coagul Fibrinolysis	Cross-therapeutic area	Goujon MA, Pesnel N, Feriel J, Duchez VLC, Mentz F, Le Boulaire F, Duriez R, De Laat B, de Maistre E, Lebreton A. Performance evaluation of Stago sthemO 301 hemostasis analyzer for routine testing, coagulation factors, and inhibitors. Blood Coagul Fibrinolysis. 2026 Mar 10. doi: 10.1097/MBC.0000000000001421. Epub ahead of print. PMID: 41808395.
A Phase IIa Randomized Clinical Trial of a Respiratory Syncytial Virus and Human Metapneumovirus Combination Protein-Based Virus-Like Particle Vaccine in Adults 60–85 Years of Age	2026	Publication		Vaccine	Virology	Davis M, Shapiro C, Ciarlet M, Adams EM, Hourguettes N, Engram AE, Wen J, Bansal H, Shoemaker K, Rida W, Aksyuk AA, Price J, Oyedele T, Chang LJ, Kanesa-Thasan N. A Phase IIa randomized clinical trial of a respiratory syncytial virus and human metapneumovirus combination protein-based virus-like particle vaccine in adults 60-85 years of age. Vaccine. 2026 Apr 2;77:128345. doi: 10.1016/j.vaccine.2026.128345. Epub 2026 Mar 4. PMID: 41785514.
Dengue Infections Among Household Contacts of Symptomatic Index Cases: Implications for Community-Based Intervention Studies	2025	Publication		Viruses	Virology	Koehne E, Van Wesenbeeck L, Hibberd ML, Buelens A, Toizumi M, Clerck K, Vijgen L, Lagatie O, Masdin L, Nguyen HAT, Le HH, Dang DA, Huynh MK, Le LT, Nguyên TB, Hue S, Do HT, Herrera-Taracena G, Rasschaert F, Yoshida LM. Dengue Infections Among Household Contacts of Symptomatic Index Cases: Implications for Community-Based Intervention Studies. Viruses. 2025 Jun 17;17(6):859. doi: 10.3390/v17060859. PMID: 40573451; PMCID: PMC12197545.
Flow Cytometry Assay Modifications: Recommendations for Method Validation Based on CLSI H62 Guidelines	2025	Publication		Cytometry B Clin Cytom	Cross-therapeutic area	Monaghan SA, Eck S, Bunting S, Dong XX, Durso RJ, Gonneau C, Hays A, Illingworth A, League SC, Linskens E, McCausland M, McCloskey TW, Rolf N, Shi M, Wallace PK, Litwin V, Kern W, Deeb G, Nash V, Olteanu H. Flow cytometry assay modifications: Recommendations for method validation based on CLSI H62 guidelines. Cytometry B Clin Cytom. 2025 May;108(3):252-266. doi: 10.1002/cyto.b.22202. Epub 2024 Aug 21. PMID: 39165120.
Human Papillomavirus (HPV) Genotypes in Mixed Squamous Cell Carcinoma of the Penis: A Study of 101 Tumors	2025	Publication		Int J Surg Pathol	Solid tumors	Fernández-Nestosa MJ, Sanchez DF, Cañete-Portillo S, Alemany L, Clavero O, Lloveras B, Rodriguez I, Lobatti A, Urizar C, Munoz N, Quint W, de Sanjosé S, Bosch FX, Cubilla AL; HPV VVAP Study Group. Human Papillomavirus (HPV) Genotypes in Mixed Squamous Cell Carcinoma of the Penis: A Study of 101 Tumors. Int J Surg Pathol. 2025 Jun;33(4):877-881. doi: 10.1177/10668969241295352. Epub 2024 Nov 13. PMID: 39535004.
Safety and Immunogenicity of a Reduced-Dose Inactivated Poliovirus Vaccine Versus a Full-Dose Inactivated Poliovirus Vaccine in Infants in Bangladesh: A Double-Blind, Non-Inferiority, Randomised, Controlled, Phase 3 Trial	2025	Publication		Lancet Infect Dis	Virology	Kulkarni PS, Zaman K, Desai SA, Bharati S, Goswami DR, Sharmeen AT, Rana S, Haque W, Khandelwal A, Manney S, Tyagi P, Gairola S, Zade JK, Pisal SS, Dhere RM, Poonawalla CS, Lamberigts C, Parulekar V, Potey AV. Safety and immunogenicity of a reduced-dose inactivated poliovirus vaccine versus a full-dose inactivated poliovirus vaccine in infants in Bangladesh: a double-blind, non-inferiority, randomised, controlled, phase 3 trial. Lancet Infect Dis. 2025 Oct;25(10):1128-1137. doi: 10.1016/S1473-3099(25)00215-4. Epub 2025 Jun 9. PMID: 40505670.
Booster Immunisation with Skin-Patch-Delivered Unadjuvanted SARS-Cov-2 Spike Protein Vaccine Is Safe and Immunogenic in Healthy Adults	2025	Publication		Vaccines (Basel)	Virology	McMillan CLD, Muller DA, Fernando GJP, Depelsenaire ACI, Jayashi-Flores C, Masterman KA, Namjoshi S, Vyas K, Pascoe D, Hickling J, Wallace S, Duijsings D, Vink J, Wheatley AK, Juno J, Siller G, Forster AH. Booster Immunisation with Skin-Patch-Delivered Unadjuvanted SARS-CoV-2 Spike Protein Vaccine Is Safe and Immunogenic in Healthy Adults. Vaccines (Basel). 2025 Dec 25;14(1):28. doi: 10.3390/vaccines14010028. PMID: 41600944; PMCID: PMC12846601.
Immune Correlates Analysis of Mrna-1345 RSV Vaccine Efficacy Clinical Trial	2025	Publication		Nat Commun	Virology	Ma C, Du J, Lan L, Kapoor A, Marc GP, Jimenez G, Duncan CJA, Le Cam N, Lin N, Priddy F, Garg S, Stoszek SK, Shaw CA, Goswami J, Wilson E, Das R, Zhou H, Zheng L. Immune correlates analysis of mRNA-1345 RSV vaccine efficacy clinical trial. Nat Commun. 2025 Jul 3;16(1):6118. doi: 10.1038/s41467-025-61153-x. PMID: 40610413; PMCID: PMC12229610.
Safety, Tolerability, and Immunogenicity of Revaccination with Mrna-1345, an Mrna Vaccine Against Respiratory Syncytial Virus, Administered 12 Months Following a Primary Dose in Adults Aged ≥50 Years	2025	Publication		Clin Infect Dis	Virology	Goswami J, Cardona JF, Caso J, Hsu DC, Simorellis AK, Wilson L, Dhar R, Wang X, Kapoor A, Collins A, Righi V, Lan L, Du J, Zhou H, Stoszek SK, Shaw CA, Reuter C, Wilson E, Das R. Safety, Tolerability, and Immunogenicity of Revaccination with mRNA-1345, an mRNA Vaccine Against RSV, Administered 12 Months Following a Primary Dose in Adults Aged ≥50 Years. Clin Infect Dis. 2025 Sep 23:ciaf515. doi: 10.1093/cid/ciaf515. Epub ahead of print. PMID: 40988124.
Drug–Fc Conjugate CD388 Targets Influenza Virus Neuraminidase and Is Broadly Protective in Mice	2025	Publication		Nat Microbiol	Virology	Döhrmann S, Levin J, Cole JN, Borchardt A, Amundson K, Almaguer A, Abelovski E, Grewal R, Zuill D, Dedeic N, Hough G, Fortier J, Donatelli J, Lam T, Chen ZY, Jiang W, Haussener T, Noncovich A, Balkovec JM, Bensen DC, Ong V, Brady TP, Locke JB, Flanagan S, Hughes RM, Stein JL, Tari LW. Drug-Fc conjugate CD388 targets influenza virus neuraminidase and is broadly protective in mice. Nat Microbiol. 2025 Apr;10(4):912-926. doi: 10.1038/s41564-025-01955-3. Epub 2025 Mar 17. PMID: 40097766; PMCID: PMC11964917.
Inhibition of Virally Induced TFEB Proteasomal Degradation as a Host-Centric Therapeutic Approach for Coronaviral Infection	2025	Publication		Sci Adv	Virology	Lear TB, Larsen MB, Lin B, Treat BR, Cao Q, Boudreau ÁN, Lockwood KC, Alfaras I, Kennerdell JR, Salminen L, Camarco DP, Tong Y, Ma J, Liu J, Tan JX, Tuncer F, Villandre JJ, Hertzel L, Myerburg MM, Chen Y, St Croix C, Sekine Y, Evankovich JW, Barratt-Boyes SM, Finkel T, Chen BB, Liu Y. Inhibition of virally induced TFEB proteasomal degradation as a host-centric therapeutic approach for coronaviral infection. Sci Adv. 2025 Jun 6;11(23):eadv4033. doi: 10.1126/sciadv.adv4033. Epub 2025 Jun 4. PMID: 40465712; PMCID: PMC12136031.
Antiviral and Immunomodulatory Effect of Zapnometinib in Animal Models and Hospitalized COVID-19 Patients	2025	Publication		Front Immunol	Virology	Füll Y, Schüssele LM, Hamza H, Hoffmann H, Bauer M, Stenglein S, Pötz O, Steinhilber A, Anselm V, Delany MW, Van den Brand JMA, Van Amerongen G, De Waal L, Pleschka S, Ludwig S, Planz O. Antiviral and immunomodulatory effect of zapnometinib in animal models and hospitalized COVID-19 patients. Front Immunol. 2025 Sep 22;16:1631721. doi: 10.3389/fimmu.2025.1631721. PMID: 41058679; PMCID: PMC12498288.
Preliminary Performance of the VIDAS TB-IGRA as an Aid in the Diagnosis of Individuals Infected with Mycobacterium Tuberculosis	2025	Publication		J Clin Microbiol	Infectious diseases	Serge Diagbouga P, Djibougou AD, Pease C, Alcaide A, Berthoux A, Bruiners N, Cirillo DM, Combary A, Falchero N, Handler D, Kaboré A, Lardizabal A, Lopes A, Loubet M, Manivet P, Margain C, Meunier V, Mougari F, Onyuka A, Rivoiron S, Sagna T, Sanvert M, Sawadogo L, Simporé J, Cambau E, Gennaro ML. Preliminary performance of the VIDAS TB-IGRA as an aid in the diagnosis of individuals infected with Mycobacterium tuberculosis. J Clin Microbiol. 2025 Jun 11;63(6):e0164124. doi: 10.1128/jcm.01641-24. Epub 2025 May 14. PMID: 40366166; PMCID: PMC12153259.
Highly Pathogenic Avian Influenza Virus A/H5N1 Subclade 2.3.4.4b Isolated From a European Grey Seal (halichoerus Grypus) Is Highly Virulent in Ferrets	2025	Publication		J Infect Dis	Virology	Guilfoyle K, Mirolo M, de Waal L, van Amerongen G, van der Net G, Störk T, Lombardo MS, Baumgärtner W, Bjarnason Á, Bryndis Jóhannsdóttir H, Rimmelzwaan G, Ludlow M, Osterhaus A. Highly Pathogenic Avian Influenza Virus A/H5N1 Subclade 2.3.4.4b Isolated from a European Grey Seal (Halichoerus grypus) Is Highly Virulent in Ferrets. J Infect Dis. 2025 Dec 20;232(6):e886-e896. doi: 10.1093/infdis/jiaf348. PMID: 40578830; PMCID: PMC12718051.
p16INK4a and HPV E4 Immunohistochemistry for the Prediction of Regression of Cervical Intraepithelial Neoplasia Grade 2: A Historical Cohort Study	2025	Publication		Int J Cancer	Solid tumors	Damgaard R, Jenkins D, Stoler MH, van de Sandt M, de Koning MNC, Quint WGV, Kahlert J, Gravitt PE, Steiniche T, Petersen LK, Hammer A. p16INK4a and HPV E4 immunohistochemistry for the prediction of regression of cervical intraepithelial neoplasia grade 2-A historical cohort study. Int J Cancer. 2025 May 5. doi: 10.1002/ijc.35469. Epub ahead of print. PMID: 40323118.
Syrian Hamsters (mesocricetus Auratus) as an Upper Respiratory Tract Model for Respiratory Syncytial Virus Infection	2025	Publication		Npj Viruses	Virology	Kolbe SM, Guilfoyle K, Reineking W, van Amerongen G, van der Net G, Lockow S, Baumgärtner W, Ludlow M, Osterhaus ADME. Syrian hamsters (Mesocricetus auratus) as an upper respiratory tract model for respiratory syncytial virus infection. Npj Viruses. 2025 Jan 8;3(1):2. doi: 10.1038/s44298-024-00086-6. PMID: 40295717; PMCID: PMC11721388.
Recommendations on Biomarker Assay Validation (BAV) in Tissues by GCC	2025	Publication		Bioanalysis	Cross-therapeutic area	Yuan M, Liu A, Xu B, Sales K, Karnik S, Voelker T, Salha D, Zimmer J, O'Dell M, Gorityala S, Hays A, Lester T, Reynolds G, Tary-Lehmann M, Yu M, Roberge M, Malone K, Patel V, Love I, Lin J, Diaz M, Xu T, Garofolo W, McGregor J, Leskovar A, Kernstock R, Pellerin M, Brown M, Spytko A, Lowes S, Ambrose D, Dufield D, Kane C, Veeramachaneni R, Luna M, Warrino D, Dwivedi V, Xu A, Hyer E, Iles T, Majumdar R, Sikkema D, Thomas E, Carlsson A, Dakappagari N, Riccitelli N, Marco CD, Bouhajib M, Iordachescu A, Sanghvi M, Barton H, Lavelle A, Dompkowski E, Rundlett S, Matys K, Sangster T, Turksma A, Gu W, Liu J, Hoffpauir B, Rocha A, Pirro J, Bergeron J, O'Brien K, Fang X, Dong K, Yamashita J. Recommendations on biomarker assay validation (BAV) in tissues by GCC. Bioanalysis. 2025 Apr;17(7):429-438. doi: 10.1080/17576180.2025.2471243. Epub 2025 Apr 18. PMID: 40248960; PMCID: PMC12026151.
Long Distance Dispersal with Kinship in the Yangtze River During Early Life Stage of a Freshwater Fish	2025	Publication		JID Innov	Rare diseases	Kravvas G, Xie B, Ganier C, van den Munckhof H, van den Munckhof E, de Koning M, Gulin SJ, Freeman A, Haider A, Alnajjar H, Muneer A, Lynch M, Millar M, Ahmed A, Bunker CB. A Direct Comparative Analysis of HPV DNA with Single-Molecule RNA and p16INK4a Protein Expression in Lichen Sclerosus: Implications for Diagnostics and Pathogenesis. JID Innov. 2025 Mar 28;5(4):100367. doi: 10.1016/j.xjidi.2025.100367. PMID: 40330849; PMCID: PMC12051593.
HPV Vaccine Impact: Genotype-Specific Changes in Cervical Pre-Cancer Share Similarities with Changes in Cervical Screening Cytology	2025	Publication		J Natl Cancer Inst	Solid tumors	Adcock R, Wheeler CM, Hunt WC, Torrez-Martinez NE, Robertson M, McDonald R, Joste NE, Stoler MH, de Koning MNC, Quint WGV; New Mexico HPV Pap Registry Steering Committee Members. HPV vaccine impact: genotype-specific changes in cervical pre-cancer share similarities with changes in cervical screening cytology. J Natl Cancer Inst. 2025 Jul 1;117(7):1377-1386. doi: 10.1093/jnci/djaf055. PMID: 40069924; PMCID: PMC12229469.
Neoadjuvant Immunotherapy with or Without Chemotherapy in Locally Advanced Oral Squamous Cell Carcinoma: Randomized, Two-Arm, Phase 2 Trial	2025	Publication		Oral Oncol	Virology	DSouza G, Tewari S, Troy T, Bleyer P, Korley M, Kwait J, Ho K, Gillison M, Wiley D, Lazar J, Weber KM, Strickler H, Lahiri CD, Palella F, Struijk L, Fakhry C. Oral HPV incidence and risk factors for acquisition. Oral Oncol. 2025 Apr;163:107249. doi: 10.1016/j.oraloncology.2025.107249. Epub 2025 Mar 17. PMID: 40101427; PMCID: PMC12051141.
Regulatory Workshop on Standardisation of Clinical Procedures, Endpoints and Data Robustness of Human Challenge Studies – A Stakeholder Meeting Report	2025	Publication		Biologicals	Virology	Meln I, Cnossen V, Corti N, Andeweg A, Baay M, Chiu C, Coia J, Cornely O, Cox RJ, Dasyam D, De Keersmaecker SCJ, Deming M, Waldock J, Engelhardt OG, Guo M, Haj-Ali Saflo O, Hensen A, Jeeninga R, Kolstoe S, Krut O, Kuijper EJ, Leal L, Mazur N, Mohn KGI, Morel S, Osterhaus A, Moreira AP, Smits WK, Sridhar S, Toomey D, van Gerven J, Vehreschild MJGT, Yarzabal JP, Zimmer-Harwood P, Neels P, Olesen OF, Roestenberg M, Kamerling IMC. Regulatory workshop on standardisation of clinical procedures, endpoints and data robustness of human challenge studies - A stakeholder meeting report. Biologicals. 2025 May;90:101818. doi: 10.1016/j.biologicals.2025.101818. Epub 2025 Jan 17. PMID: 39824043.
17th GCC Closed Forum: Integrative Bioanalysis, Patient-Centric Sampling, Emerging Technologies, Data Integrity, Sample Reconciliation, Discrepancies of Elispot Data, Cross-Validation Harmonization, Ultrasensitive Platforms for ADA Assays, Remote Regulatory Assessments, Shedding Assays by PCR, and Biomarker Tissue Assays	2025	Publication		Bioanalysis	Cross-therapeutic area	Zimmer J, O'dell M, Johnson D, Hays A, Gorityala S, Tary-Lehmann M, Malone K, Diaz M, Xu T, Dwivedi V, Dufield D, Iles T, Sikkema D, Majumdar R, Riccitelli N, Yuan M, Lowes S, Liu A, Matys K, Turksma A, Pirro J, Bergeron J, Karnik S, Voelker T, Salha D, Reynolds G, Lamy C, Yu M, Garofolo W, Nadarajah S, Leskovar A, Pellerin M, Veeramachaneni R, Kane C, Xu A, Hyer E, Carlsson A, Sanghvi M, Dompkowski E, Rundlett S, Bower J, Spytko A, Liu J, Gu W, Rocha A, O'Brien K, Fang X. 17th GCC Closed Forum: Integrative Bioanalysis, Patient-centric Sampling, Emerging Technologies, Data Integrity, Sample Reconciliation, Discrepancies of ELISpot Data, Cross-validation Harmonization, Ultrasensitive Platforms for ADA Assays, Remote Regulatory Assessments, Shedding Assays by PCR, and Biomarker Tissue Assays. Bioanalysis. 2025 Jun;17(12):769-786. doi: 10.1080/17576180.2025.2529119. Epub 2025 Aug 18. PMID: 40823769; PMCID: PMC12367079.
Facing the New IVD Regulation 2017/746: Contract Research Organizations (cros), Key Partners of Ivds Manufacturers for Compliance	2024	Publication		Clin Chem Lab Med	Cross-therapeutic area	Kali S, Puisney C, Delalande ML, Franc G, Buisson C, Barradeau S. Facing the new IVD Regulation 2017/746: Contract Research Organizations (CROs), key partners of IVDs manufacturers for compliance. Clin Chem Lab Med. 2024 Apr 12;62(9):e206-e208. doi: 10.1515/cclm-2024-0389. PMID: 38602283.
Performance Evaluation of the New Access HIV Ag/Ab Combo Assay on the Dxi 9000 Access Immunoassay Analyzer	2024	Publication		J Clin Virol	Virology	Lemée V, Gréaume S, Gautier J, Dzamitika SA, Coignard C, Jortani SA, Grillet B, Badawi M, Plantier JC. Performance evaluation of the new Access HIV Ag/Ab combo assay on the DxI 9000 Access Immunoassay Analyzer. J Clin Virol. 2024 Jul 7;174:105712. doi: 10.1016/j.jcv.2024.105712. Epub ahead of print. PMID: 39047323.
Performance Evaluation of the Access Anti-Hbc Total Assay on the Dxi 9000 Access Immunoassay Analyzer	2024	Publication		Diagn Microbiol Infect Dis	Cross-therapeutic area	Dzamitika S, Boulaire FL, Coignard C, Vincent C, Plantier JC, Lemée V, Gréaume S, Voisin I, Brochot E, Herpe YE, Demirdjian G, Karagueuzian M, Afful D, Bayoud R, Hey J. Performance evaluation of the Access anti-HBc Total assay on the DxI 9000 Access Immunoassay Analyzer. Diagn Microbiol Infect Dis. 2024 Sep;110(1):116303. doi: 10.1016/j.diagmicrobio.2024.116303. Epub 2024 Apr 20. PMID: 38838460.
Safety, Reactogenicity and Immunogenicity of an Intranasal Seasonal Influenza Vaccine Adjuvanted with Gram-Positive Matrix (GEM) Particles (flugem): A Randomized, Double-Blind, Controlled, Ascending Dose Study in Healthy Adults and Elderly	2024	Publication		Vaccine	Virology	van der Plas JL, Haijema BJ, Leenhouts K, Paul Zoeteweij J, Burggraaf J, Kamerling IMC. Safety, reactogenicity and immunogenicity of an intranasal seasonal influenza vaccine adjuvanted with gram-positive matrix (GEM) particles (FluGEM): A randomized, double-blind, controlled, ascending dose study in healthy adults and elderly. Vaccine. 2024 Sep 17;42(22):125836. doi: 10.1016/j.vaccine.2024.03.063. Epub 2024 May 20. PMID: 38772837.
Susceptibility of Calf Lung Slice Cultures to H5N1 Influenza Virus	2024	Publication		Emerg Microbes Infect	Virology	Guilfoyle K, Mirolo M, van Amerongen G, van der Net G, Lombardo MS, Störk T, Rimmelzwaan G, Ludlow M, Osterhaus A. Susceptibility of calf lung slice cultures to H5N1 influenza virus. Emerg Microbes Infect. 2025 Dec;14(1):2432368. doi: 10.1080/22221751.2024.2432368. Epub 2024 Dec 9. PMID: 39624917; PMCID: PMC11632935.
Inno4Vac Workshop Report Part 2: Rsv‑controlled Human Infection Model (CHIM) Strain Selection and Immune Assays for RSV CHIM Studies, November 2021, MHRA, UK	2024	Publication		Influenza Other Respi Viruses	Virology	Waldock J, Cox RJ, Engelhardt OG, Ascough S, Osterhaus A, Rimmelzwaan GF, Ludlow M, Tregoning JS, McDonald JU, Buchholz UJ, Jeeninga RE, Sande C, Chiu C (2024), Inno4Vac Workshop Report Part 2: RSV-Controlled Human Infection Model (CHIM) Strain Selection and Immune Assays for RSV CHIM Studies, November 2021, MHRA, UK. Influenza Other Respi Viruses, 18: e70013. https://doi.org/10.1111/irv.70013
16th GCC Closed Forum: ICH M10 Implementation; NGS, Qpcr/Dpcr, Flow Cytometry Validation; Tissue Biomarkers; IS Response; Immunogenicity Harmonization; Bioanalytical Industry Status	2024	Publication		Bioanalysis	Cross-therapeutic area	Zimmer J, Hays A, Lester T, Diaz M, Thomas E, O'Dell M, Hyer E, Tangri S, Dakappagari N, Yuan M, Lavelle A, Karnik S, Liu A, Xu B, Sales K, Gorityala S, Reynolds G, Sangster T, Franckaert D, Love I, Patel V, Roberge M, Lin J, Jerks E, Xu T, Garofolo W, Nadarajah S, Kernstock R, Dufield D, Ambrose D, Warrino D, Luna M, Marco CD, Tudoroniu A, Iordachescu A, Sanghvi M, Barton H, Brown M, Hoffpauir B, Rocha A, Dong K, Yamashita J. 16th GCC Closed Forum: ICH M10 implementation; NGS, qPCR/dPCR, flow cytometry validation; tissue biomarkers; IS response; immunogenicity harmonization; bioanalytical industry status. Bioanalysis. 2024 Jun 2;16(11):505-517. doi: 10.1080/17576180.2024.2342691. Epub 2024 Jun 12. PMID: 38864397; PMCID: PMC11299793.
Viral Load in Hospitalized Infants with Respiratory Syncytial Virus Bronchiolitis: A Three-Way Comparative Analysis	2024	Publication		Eur J Pediatr	Virology	Golan-Tripto I, Danino D, De Waal L, Akel K, Dizitzer-Hillel Y, Tal A, Langman Y, Goldbart A. Viral load in hospitalized infants with respiratory syncytial virus bronchiolitis: a three-way comparative analysis. Eur J Pediatr. 2024 Aug;183(8):3471-3478. doi: 10.1007/s00431-024-05614-3. Epub 2024 May 23. PMID: 38780651.
Bacterial Vaginosis in a Subfertile Population Undergoing Fertility Treatments: A Prospective Cohort Study	2024	Publication		J Assist Reprod Genet	Infectious diseases	van den Tweel MM, van den Munckhof EHA, van der Zanden M, Molijn AC, van Lith JMM, Le Cessie S, Boers KE. Bacterial vaginosis in a subfertile population undergoing fertility treatments: a prospective cohort study. J Assist Reprod Genet. 2024 Feb;41(2):441-450. doi: 10.1007/s10815-023-03000-w. Epub 2023 Dec 13. PMID: 38087161; PMCID: PMC10894785.
Human Papillomavirus Genotypes and Risk of Persistence and Progression in Women Undergoing Active Surveillance for Cervical Intraepithelial Neoplasia Grade 2	2024	Publication		Am J Obs Gyn	Solid tumors	Damgaard RK, Jenkins D, Stoler MH, de Koning M, van de Sandt M, Lycke KD, Kahlert J, Gravitt PE, Quint WGV, Steiniche T, Petersen LK, Hammer A. Human papillomavirus genotypes and risk of persistence and progression in women undergoing active surveillance for cervical intraepithelial neoplasia grade 2. Am J Obstet Gynecol. 2024 Jun;230(6):655.e1-655.e10. doi: 10.1016/j.ajog.2024.01.029. Epub 2024 Feb 7. PMID: 38336125.
The Vaginal Microbiome Changes During Various Fertility Treatments	2024	Publication		Reprod Sci	Virology	van den Tweel MM, van den Munckhof EHA, van der Zanden M, Molijn A, van Lith JMM, Boers KE. The Vaginal Microbiome Changes During Various Fertility Treatments. Reprod Sci. 2024 Jun;31(6):1593-1600. doi: 10.1007/s43032-024-01484-0. Epub 2024 Feb 20. PMID: 38379070; PMCID: PMC11111482.
Assessment of CD8+ T-Cell Mediated Immunity in an Influenza A(H3N2) Human Challenge Model in Belgium: A Single Centre, Randomised, Double-Blind Phase 2 Study	2024	Publication		Lancet Microbe	Virology	Evans TG, Castellino F, Kowalik Dobczyk M, Tucker G, Walley AM, Van Leuven K, Klein J, Rutkowski K, Ellis C, Eagling-Vose E, Treanor J, van Baalen C, Filkov E, Laurent C, Thacker J, Asher J, Donabedian A. Assessment of CD8+ T-cell mediated immunity in an influenza A(H3N2) human challenge model in Belgium: a single centre, randomised, double-blind phase 2 study. Lancet Microbe. 2024 Jul;5(7):645-654. doi: 10.1016/S2666-5247(24)00024-7. Epub 2024 May 7. PMID: 38729196.
Adeno-Associated Virus Serotype 9 Antibodies in Neonates and Young Children: Seroprevalence and Kinetics	2024	Publication		Mol Ther Methods Clin Dev	Neurology	van Olden RW, Lo Bianco C, Dilly KW, Savelieva M, Xu S, Tijsma A, van Baalen C, Sharma H, Mumneh N. Adeno-associated virus serotype 9 antibodies in neonates and young children: Seroprevalence and kinetics. Mol Ther Methods Clin Dev. 2024 Sep 21;32(4):101344. doi: 10.1016/j.omtm.2024.101344. PMID: 40018025; PMCID: PMC11866128.
Testing on Bacterial Vaginosis in a Subfertile Population and Time to Pregnancy: A Prospective Cohort Study	2024	Publication		Arch Gynecol Obstet	Infectious diseases	van den Tweel M, van den Munckhof E, van der Zanden M, Le Cessie S, van Lith J, Boers K. Testing on bacterial vaginosis in a subfertile population and time to pregnancy: a prospective cohort study. Arch Gynecol Obstet. 2024 May 16. doi: 10.1007/s00404-024-07542-x. Epub ahead of print. PMID: 38753204.
Multiplexed Multicolor Antiviral Assay Amenable for High-Throughput Research	2024	Publication		Nat Commun	Virology	Li LH, Chiu W, Huang YA, Rasulova M, Vercruysse T, Thibaut HJ, Ter Horst S, Rocha-Pereira J, Vanhoof G, Borrenberghs D, Goethals O, Kaptein SJF, Leyssen P, Neyts J, Dallmeier K. Multiplexed multicolor antiviral assay amenable for high-throughput research. Nat Commun. 2024 Jan 2;15(1):42. doi: 10.1038/s41467-023-44339-z. PMID: 38168091; PMCID: PMC10761739.
Standardised Quantitative Assays for Anti-SARS-Cov-2 Immune Response Used in Vaccine Clinical Trials by the CEPI Centralized Laboratory Network: A Qualification Analysis	2024	Publication		Lancet Microbe	Virology	Manak M, Gagnon L, Phay-Tran S, Levesque-Damphousse P, Fabie A, Daugan M, Khan ST, Proud P, Hussey B, Knott D, Charlton S, Hallis B, Medigeshi GR, Garg N, Anantharaj A, Raqib R, Sarker P, Alam MM, Rahman M, Murreddu M, Balgobind A, Hofman R, Grappi S, Coluccio R, Calandro P, Montomoli E, Mattiuzzo G, Prior S, Le Duff Y, Page M, Mitchell J, Schwartz LM, Bartsch YC, Azizi A, Bernasconi V; CEPI CLN Study Group. Standardised quantitative assays for anti-SARS-CoV-2 immune response used in vaccine clinical trials by the CEPI Centralized Laboratory Network: a qualification analysis. Lancet Microbe. 2024 Mar;5(3):e216-e225. doi: 10.1016/S2666-5247(23)00324-5. Epub 2024 Jan 23. PMID: 38278167.
Oncogenic Oral Human Papillomavirus Clearance Patterns Over 10 Years	2024	Publication		Cancer Epidemiol Biomarkers Prev	Virology	D'Souza G, Tewari SR, Troy T, Webster-Cyriaque J, Wiley DJ, Lahiri CD, Palella FJ, Gillison ML, Strickler HD, Struijk L, Waterboer T, Ho K, Kwait J, Lazar J, Weber KM, Fakhry C. Oncogenic Oral Human Papillomavirus Clearance Patterns Over 10 years. Cancer Epidemiol Biomarkers Prev. 2024 Jan 31. doi: 10.1158/1055-9965.EPI-23-1272. Epub ahead of print. PMID: 38294704.
Assessment of the Broad-Spectrum Host Targeting Antiviral Efficacy of Halofuginone Hydrobromide in Human Airway, Intestinal and Brain Organotypic Models	2024	Publication		Antiviral Res	Virology	García-Rodríguez I, Moreni G, Capendale PE, Mulder L, Aknouch I, Vieira de Sá R, Johanneson N, Freeze E, van Eijk H, Koen G, Wolthers K, Pajkrt D, Sridhar A, Calitz C. Assessment of the broad-spectrum host targeting antiviral efficacy of halofuginone hydrobromide in human airway, intestinal and brain organotypic models. Antiviral Res. 2024 Jan 6:105798. doi: 10.1016/j.antiviral.2024.105798. Epub ahead of print. PMID: 38190972.
Monitoring Multiple Myeloma Patients Treated with Daratumumab: Teasing Out Monoclonal Antibody Interference	2024	Publication		Clinical Chemistry and Laboratory Medicine	Hematological malignancies	Christopher McCudden, Amy E. Axel, Dominique Slaets, Thomas Dejoie, Pamela L. Clemens, Sandy Frans, Jaime Bald, Torben Plesner, Joannes F.M. Jacobs, Niels W.C.J. van de Donk, Philippe Moreau, Jordan M. Schecter, Tahamtan Ahmadi, A. Kate Sasser
Trial by Ordeal of Unprecedented Global Pandemic	2024	Publication		Clinical Trials Insight	Infectious diseases	Mario Papillon
Measurable Success: The Value of Biomarkers From Discovery Through Commercialization	2024	Publication		Cerba Research	Cross-therapeutic area	Jerome Sallette
Africa: An Advantageous Landscape for Conducting Clinical Trials	2024	Publication		Clinical Trials Insight	Cross-therapeutic area	Barc Lab
Sociodemographic Characteristics and Screening Outcomes of Women Preferring Self-Sampling in the Dutch Cervical Cancer Screening Programme: A Population-Based Study	2023	Publication		Cancer Epidemiol Biomarkers Prev	Solid tumors	Aitken CA, Inturrisi F, Kaljouw S, Nieboer D, Siebers AG, Melchers WJG, van den Brule AJC, Molijn A, Hinrichs JWJ, Niesters HGM, van Kemenade FJ, Berkhof J, de Kok IMCM. Sociodemographic Characteristics and Screening Outcomes of Women Preferring Self-Sampling in the Dutch Cervical Cancer Screening Programme: A Population-Based Study. Cancer Epidemiol Biomarkers Prev. 2023 Feb 6;32(2):183-192. doi: 10.1158/1055-9965.EPI-22-0712. PMID: 36099416; PMCID: PMC9900317.
An External Quality Assessment Feasibility Study; Cross Laboratory Comparison of Haemagglutination Inhibition Assay and Microneutralization Assay Performance for Seasonal Influenza Serology Testing: A FLUCOP Study	2023	Publication		Front Immunol	Virology	Waldock J, Weiss CD, Wang W, Levine MZ, Jefferson SN, Ho S, Hoschler K, Londt BZ, Masat E, Carolan L, Sánchez-Ovando S, Fox A, Watanabe S, Akimoto M, Sato A, Kishida N, Buys A, Maake L, Fourie C, Caillet C, Raynaud S, Webby RJ, DeBeauchamp J, Cox RJ, Lartey SL, Trombetta CM, Marchi S, Montomoli E, Sanz-Muñoz I, Eiros JM, Sánchez-Martínez J, Duijsings D, Engelhardt OG. An external quality assessment feasibility study; cross laboratory comparison of haemagglutination inhibition assay and microneutralization assay performance for seasonal influenza serology testing: A FLUCOP study. Front Immunol. 2023 Feb 28;14:1129765. doi: 10.3389/fimmu.2023.1129765. PMID: 36926342; PMCID: PMC10011125.
Therapeutic Vaccination Against Human Papillomavirus Type 16 for the Treatment of High-Grade Anal Intraepithelial Neoplasia in HIV+ Men	2023	Publication		Clin Cancer Res	Solid tumors	Gosens KCM, van der Burg SH, Welters MJP, Boekestijn S, Loof NM, Quint WGV, van Noesel CJM, van der Wal AC, Richel O, Krebber WJTA, Melief CJM, de Vries HJC, Prins JM. Therapeutic Vaccination against Human Papillomavirus Type 16 for the Treatment of High-Grade Anal Intraepithelial Neoplasia in HIV+ Men. Clin Cancer Res. 2023 Oct 13;29(20):4109-4117. doi: 10.1158/1078-0432.CCR-22-3361. PMID: 37540563.
Carbohydrate Fatty Acid Monosulphate Ester Is a Potent Adjuvant for Low-Dose Seasonal Influenza Vaccines	2023	Publication		Vaccine	Virology	Platenburg PPLI, Deschamps F, Jung J, Leonard C, Rusconi S, Mohan Kumar SB, Sulaiman SM, de Waal L, Hilgers LAT. Carbohydrate fatty acid monosulphate ester is a potent adjuvant for low-dose seasonal influenza vaccines. Vaccine. 2023 Nov 13;41(47):6980-6990. doi: 10.1016/j.vaccine.2023.10.017. Epub 2023 Oct 16. PMID: 37852870.
Reproducible and Clinically Translatable Deep Neural Networks for Cervical Screening	2023	Publication		Sci Rep	Solid tumors	Ahmed SR, Befano B, Lemay A, Egemen D, Rodriguez AC, Angara S, Desai K, Jeronimo J, Antani S, Campos N, Inturrisi F, Perkins R, Kreimer A, Wentzensen N, Herrero R, Del Pino M, Quint W, de Sanjose S, Schiffman M, Kalpathy-Cramer J. Reproducible and clinically translatable deep neural networks for cervical screening. Sci Rep. 2023 Dec 8;13(1):21772. doi: 10.1038/s41598-023-48721-1. PMID: 38066031; PMCID: PMC10709439.
Changes of the Bacterial Composition in Duodenal Fluid From Patients with Liver Cirrhosis and Molecular Bacterascites	2023	Publication		Sci Rep	Infectious diseases	Höppner J, Krohn S, van den Munckhof EHA, Kallies R, Herber A, Zeller K, Tünnemann J, Matz-Soja M, Chatzinotas A, Böhm S, Hoffmeister A, Berg T, Engelmann C. Changes of the bacterial composition in duodenal fluid from patients with liver cirrhosis and molecular bacterascites. Sci Rep. 2023 Dec 27;13(1):23001. doi: 10.1038/s41598-023-49505-3. PMID: 38155157; PMCID: PMC10754895.
Dynamic Changes of the Gut Microbial Colonization in Preterm Infants with Different Time Points After Birth	2023	Publication		Front Microbiol	Virology	Aknouch I, García-Rodríguez I, Giugliano FP, Calitz C, Koen G, van Eijk H, Johannessson N, Rebers S, Brouwer L, Muncan V, Stittelaar KJ, Pajkrt D, Wolthers KC, Sridhar A. Amino acid variation at VP1-145 of enterovirus A71 determines the viral infectivity and receptor usage in a primary human intestinal model. Front Microbiol. 2023 Apr 17;14:1045587. doi: 10.3389/fmicb.2023.1045587. PMID: 37138595; PMCID: PMC10149690.
Preclinical Immunogenicity and Protective Efficacy of a SARS-Cov-2 RBD-Based Vaccine Produced with the Thermophilic Filamentous Fungal Expression System Thermothelomyces Heterothallica C1	2023	Publication		Front Immunol	Virology	Gonzalez-Hernandez M, Kaiser FK, Steffen I, Ciurkiewicz M, van Amerongen G, Tchelet R, Emalfarb M, Saloheimo M, Wiebe MG, Vitikainen M, Albulescu IC, Bosch BJ, Baumgärtner W, Haagmans BL, Osterhaus ADME. Preclinical immunogenicity and protective efficacy of a SARS-CoV-2 RBD-based vaccine produced with the thermophilic filamentous fungal expression system Thermothelomyces heterothallica C1. Front Immunol. 2023 Jun 9;14:1204834. doi: 10.3389/fimmu.2023.1204834. PMID: 37359531; PMCID: PMC10289020.
Inoculation of Raccoons with a Wild-Type-Based Recombinant Canine Distemper Virus Results in Viremia, Lymphopenia, Fever, and Widespread Histological Lesions	2023	Publication		mSphere	Infectious diseases	Roelofs D, Schmitz KS, van Amerongen G, Rijsbergen LC, Laksono BM, Comvalius AD, Nambulli S, Rennick LJ, van Run P, Duprex WP, van den Brand JMA, de Swart RL, de Vries RD. Inoculation of raccoons with a wild-type-based recombinant canine distemper virus results in viremia, lymphopenia, fever, and widespread histological lesions. mSphere. 2023 Aug 24;8(4):e0014423. doi: 10.1128/msphere.00144-23. Epub 2023 Jun 14. PMID: 37314205; PMCID: PMC10449507.
Papilloplex HR-HPV Test Has Non-Inferior Clinical Performance for Detection of Human Papillomavirus Infection: Assessment Using the VALGENT Framework	2023	Publication		J Clin Pathol	Virology	Bhatia R, Alcaniz Boada E, Bonde JH, Quint WGV, Xu L, Ejegod DM, Cuschieri K, Arbyn M. Papilloplex HR-HPV test has non-inferior clinical performance for detection of human papillomavirus infection: assessment using the VALGENT framework. J Clin Pathol. 2023 Mar;76(3):172-176. doi: 10.1136/jclinpath-2021-207864. Epub 2021 Nov 15. PMID: 34782423; PMCID: PMC9985714.
Detection of Variable Genotypes in Common Human Papillomavirus-Associated Invasive Penile Squamous Cell Carcinomas: A Study of 177 Human Papillomavirus-Positive Cases	2023	Publication		Hum Pathol	Solid tumors	Sanchez DF, Fernández-Nestosa MJ, Alemany L, Cañete-Portillo S, Lloveras B, Clavero O, Rodríguez I, Quint W, Muñoz N, de Sanjosé S, Bosch FX, Cubilla AL; HPV VVAP Study Group. Detection of variable genotypes in common human papillomavirus-associated invasive penile squamous cell carcinomas: a study of 177 human papillomavirus-positive cases. Hum Pathol. 2023 Sep;139:65-72. doi: 10.1016/j.humpath.2023.07.001. Epub 2023 Jul 8. PMID: 37429448.
High Prevalence of HPV16 and High-Grade Cytology in Women Undergoing Active Surveillance for Cervical Intraepithelial Neoplasia Grade 2	2023	Publication		Acta Obstet Gynecol Scand	Solid tumors	Damgaard RK, Jenkins D, Stoler MH, van de Sandt MM, Lycke KD, de Koning MNC, Quint WGV, Steiniche T, Petersen LK, Hammer A. High prevalence of HPV16 and high-grade cytology in women undergoing active surveillance for cervical intraepithelial neoplasia grade 2. Acta Obstet Gynecol Scand. 2023 Sep;102(9):1227-1235. doi: 10.1111/aogs.14627. Epub 2023 Jul 19. PMID: 37469102.
Flow Cytometry Method Validation Protocols	2023	Publication		Curr Protoc	Cross-therapeutic area	Selliah N, Nash V, Eck S, Green C, Oldaker T, Stewart J, Vitaliti A, Litwin V. Flow Cytometry Method Validation Protocols. Curr Protoc. 2023 Aug;3(8):e868. doi: 10.1002/cpz1.868. PMID: 37606503.
Differences in the Urinary Microbiome of Patients with Overactive Bladder Syndrome with and Without Detrusor Overactivity on Urodynamic Measurements	2023	Publication		Life	Metabolic	Javan Balegh Marand A, Baars C, Heesakkers J, van den Munckhof E, Ghojazadeh M, Rahnama'i MS, Janssen D. Differences in the Urinary Microbiome of Patients with Overactive Bladder Syndrome with and without Detrusor Overactivity on Urodynamic Measurements. Life (Basel). 2023 May 17;13(5):1199. doi: 10.3390/life13051199. PMID: 37240844; PMCID: PMC10222553.
Antigenic Mapping of Emerging SARS-Cov-2 Omicron Variants BM.1.1.1, BQ.1.1, and XBB.1	2023	Publication		Lancet Microbe	Virology	Mykytyn AZ, Rosu ME, Kok A, Rissmann M, van Amerongen G, Geurtsvankessel C, de Vries RD, Munnink BBO, Smith DJ, Koopmans MPG, Lamers MM, Fouchier RAM, Haagmans BL. Antigenic mapping of emerging SARS-CoV-2 omicron variants BM.1.1.1, BQ.1.1, and XBB.1. Lancet Microbe. 2023 May;4(5):e294-e295. doi: 10.1016/S2666-5247(22)00384-6. Epub 2023 Jan 16. Erratum in: Lancet Microbe. 2023 Mar;4(3):e136. PMID: 36657480; PMCID: PMC9842387.
Prevalence of Oral and Blood Oncogenic Human Papillomavirus Biomarkers Among an Enriched Screening Population: Baseline Results of the MOUTH Study	2023	Publication		Cancer	Solid tumors	D'Souza G, Tewari SR, Troy T, Waterboer T, Struijk L, Castillo R, Wright H, Shen M, Miles B, Johansson M, Robbins HA, Fakhry C. Prevalence of oral and blood oncogenic human papillomavirus biomarkers among an enriched screening population: Baseline results of the MOUTH study. Cancer. 2023 Apr 9. doi: 10.1002/cncr.34783. Epub ahead of print. PMID: 37032449.
FAM19A4/miR124-2 Methylation Testing and Human Papillomavirus (HPV) 16/18 Genotyping in HPV-Positive Women Under the Age of 30 Years	2023	Publication		Clin Infect Dis	Virology	Vink FJ, Meijer CJLM, Hesselink AT, Floore AN, Lissenberg-Witte BI, Bonde JH, Pedersen H, Cuschieri K, Bhatia R, Poljak M, Oštrbenk Valenčak A, Hillemanns P, Quint WGV, Del Pino M, Kenter GG, Steenbergen RDM, Heideman DAM, Bleeker MCG. FAM19A4/miR124-2 Methylation Testing and Human Papillomavirus (HPV) 16/18 Genotyping in HPV-Positive Women Under the Age of 30 Years. Clin Infect Dis. 2023 Feb 8;76(3):e827-e834. doi: 10.1093/cid/ciac433. PMID: 35686306; PMCID: PMC9907535.
Viral Clearance, Pharmacokinetics and Tolerability of Ensovibep in Patients with Mild to Moderate COVID-19: A Phase 2a, Open-Label, Single-Dose Escalation Study	2023	Publication		Br J Clin Pharmacol	Virology	Prins MLM, van der Plas JL, Vissers MFJM, Berends CL, Tresch G, Soergel M, Fernández E, van den Berge N, Duijsings D, Zitt C, Stavropoulou V, Zimmermann M, Drake RF, Burggraaf J, Groeneveld GH, Kamerling IMC. Viral clearance, pharmacokinetics and tolerability of ensovibep in patients with mild to moderate COVID-19: A phase 2a, open-label, single-dose escalation study. Br J Clin Pharmacol. 2023 Mar;89(3):1105-1114. doi: 10.1111/bcp.15560. Epub 2022 Oct 24. PMID: 36214216; PMCID: PMC9875039.
T Cell Immunity Ameliorates COVID-19 Disease Severity and Provides Post-Exposure Prophylaxis After Peptide-Vaccination, in Syrian Hamsters	2023	Publication		Front Immunol	Virology	Somogyi E, Kremlitzka M, Csiszovszki Z, Molnár L, Lőrincz O, Tóth J, de Waal L, Pattijn S, Reineking W, Beineke A, Tőke ER. T cell immunity ameliorates COVID-19 disease severity and provides post-exposure prophylaxis after peptide-vaccination, in Syrian hamsters. Front Immunol. 2023 Jan 24;14:1111629. doi: 10.3389/fimmu.2023.1111629. PMID: 36761759; PMCID: PMC9902696.
Intramuscular AZD7442 (tixagevimab–Cilgavimab) for Prevention of Covid-19	2022	Publication		NEJM	Virology	Levin MJ, Ustianowski A, De Wit S, Launay O, Avila M, Templeton A, Yuan Y, Seegobin S, Ellery A, Levinson DJ, Ambery P, Arends RH, Beavon R, Dey K, Garbes P, Kelly EJ, Koh GCKW, Near KA, Padilla KW, Psachoulia K, Sharbaugh A, Streicher K, Pangalos MN, Esser MT; PROVENT Study Group. Intramuscular AZD7442 (Tixagevimab-Cilgavimab) for Prevention of Covid-19. N Engl J Med. 2022 Jun 9;386(23):2188-2200. doi: 10.1056/NEJMoa2116620. Epub 2022 Apr 20. PMID: 35443106; PMCID: PMC9069994.
Dynamics of Circulating Calprotectin Accurately Predict the Outcome of Moderate COVID-19 Patients	2022	Publication		EBioMedicine	Virology	Chapuis N, Ibrahimi N, Belmondo T, Goulvestre C, Berger AE, Mariaggi AA, Andrieu M, Chenevier-Gobeaux C, Bayle A, Campos L, Cheurfa C, Chocron R, Diehl JL, Doumenc B, Duchemin J, Duprat M, François F, Gendron N, Mirault T, Pène F, Philippe A, Pommeret F, Sanchez O, Smadja DM, Szwebel TA, Silvin A, Ginhoux F, Lacroix L, Jules-Clément G, Rapeteramana S, Mavier C, Steller L, Perniconi B, André F, Drubay D, Fontenay M, Hüe S, Paul S, Solary E. Dynamics of circulating calprotectin accurately predict the outcome of moderate COVID-19 patients. EBioMedicine. 2022 Jun;80:104077. doi: 10.1016/j.ebiom.2022.104077. Epub 2022 May 26. PMID: 35644124; PMCID: PMC9132728.
Recommendations on Elispot Assay Validation by the GCC	2022	Publication		Bioanalysis	Cross-therapeutic area	Islam R, Vance J, Poirier M, Zimmer J, Khadang A, Williams D, Zemo J, Lester T, Fjording M, Hays A, Hughes N, Garofolo F, Sheldon C, Guilbaud R, Satterwhite C, Colletti K, Groeber E, Renfrew H, Yu M, Lin J, Fang X, Wissel M, Beadnell T, Lin J, Shah S, Garofolo W, Savoie N, Hayes R, Pirro J, Kane C, Luna M, Xu A, Cape S, O'Dell M, Wheller R, Ritzen H, Farley E, Kierstead L, Mylott W, Tabler E, Yuan M, Karnik S, Voelker T, DuBey I, Williard C, Dong K, Shi J, Yamashita J. Recommendations on ELISpot assay validation by the GCC. Bioanalysis. 2022 Feb;14(4):187-193. doi: 10.4155/bio-2022-0010. PMID: 35135309.
Recommendations on Qpcr/Ddpcr Assay Validation by GCC	2022	Publication		Bioanalysis	Cross-therapeutic area	Wissel M, Poirier M, Satterwhite C, Lin J, Islam R, Zimmer J, Khadang A, Zemo J, Lester T, Fjording M, Hays A, Hughes N, Garofolo F, Guilbaud R, Groeber E, Renfrew H, Colletti K, Yu M, Lin J, Fang X, Shah S, Garofolo W, Kar S, Hayes R, Pirro J, Kane C, Luna M, Xu A, Cape S, O'Dell M, Wheller R, Ritzen H, Vance J, Farley E, Matys K, Tabler E, Mylott W, Yuan M, Karnik S, Voelker T, DuBey I, Williard C, Shi J, Yamashita J. Recommendations on qPCR/ddPCR assay validation by GCC. Bioanalysis. 2022 Jun;14(12):853-863. doi: 10.4155/bio-2022-0109. Epub 2022 Jun 15. PMID: 35703321.
Human Milk Inhibits Some Enveloped Virus Infections, Including SARS-Cov-2, in an Intestinal Model	2022	Publication		Life Sci Alliance	Virology	Aknouch I, Sridhar A, Freeze E, Giugliano FP, van Keulen BJ, Romijn M, Calitz C, García-Rodríguez I, Mulder L, Wildenberg ME, Muncan V, van Gils MJ, van Goudoever JB, Stittelaar KJ, Wolthers KC, Pajkrt D. Human milk inhibits some enveloped virus infections, including SARS-CoV-2, in an intestinal model. Life Sci Alliance. 2022 Aug 4;5(12):e202201432. doi: 10.26508/lsa.202201432. PMID: 35926873; PMCID: PMC9354649.
SARS-Cov-2 Omicron Variant Causes Mild Pathology in the Upper and Lower Respiratory Tract of Hamsters	2022	Publication		Nat Commun	Virology	Armando F, Beythien G, Kaiser FK, Allnoch L, Heydemann L, Rosiak M, Becker S, Gonzalez-Hernandez M, Lamers MM, Haagmans BL, Guilfoyle K, van Amerongen G, Ciurkiewicz M, Osterhaus ADME, Baumgärtner W. SARS-CoV-2 Omicron variant causes mild pathology in the upper and lower respiratory tract of hamsters. Nat Commun. 2022 Jun 20;13(1):3519. doi: 10.1038/s41467-022-31200-y. PMID: 35725735; PMCID: PMC9207884.
Interlaboratory Reproducibility of Standardized Hemagglutination Inhibition Assays	2022	Publication		mSphere	Cross-therapeutic area	Bibby DC, Savanovic M, Zhang J, Torelli A, Jeeninga RE, Gagnon L, Harris SL. Interlaboratory Reproducibility of Standardized Hemagglutination Inhibition Assays. mSphere. 2022 Feb 23;7(1):e0095321. doi: 10.1128/msphere.00953-21. Epub 2022 Feb 23. PMID: 35196123; PMCID: PMC8865924.
Performance of HPV E4 and p16 Biomarkers in Predicting Regression of Cervical Intraepithelial Neoplasia Grade 2 (CIN2): Protocol for a Historical Cohort Study	2022	Publication		BMJ Open	Solid tumors	Damgaard RK, Jenkins D, de Koning MN, Quint WG, Stoler MH, Doorbar J, Kahlert J, Gravitt PE, Steiniche T, Petersen LK, Hammer A. Performance of HPV E4 and p16INK4a biomarkers in predicting regression of cervical intraepithelial neoplasia grade 2 (CIN2): protocol for a historical cohort study. BMJ Open. 2022 Jul 6;12(7):e059593. doi: 10.1136/bmjopen-2021-059593. PMID: 35793925; PMCID: PMC9260811.
Identifying Molecular Changes in Early Cervical Cancer Samples of Patients That Developed Metastasis	2022	Publication		Front Oncol	Solid tumors	de Geus V, Ewing-Graham PC, de Koning W, de Koning MNC, van den Bosch TPP, Nigg AL, van Eijck CHJ, Jozwiak M, van Beekhuizen HJ, Mustafa DAM. Identifying Molecular Changes in Early Cervical Cancer Samples of Patients That Developed Metastasis. Front Oncol. 2022 Jan 11;11:715077. doi: 10.3389/fonc.2021.715077. PMID: 35087740; PMCID: PMC8787153
An ACE2-Blocking Antibody Confers Broad Neutralization and Protection Against Omicron and Other SARS-Cov-2 Variants of Concern	2022	Publication		Sci Immunol	Virology	Du W, Hurdiss DL, Drabek D, Mykytyn AZ, Kaiser FK, González-Hernández M, Muñoz-Santos D, Lamers MM, van Haperen R, Li W, Drulyte I, Wang C, Sola I, Armando F, Beythien G, Ciurkiewicz M, Baumgärtner W, Guilfoyle K, Smits T, van der Lee J, van Kuppeveld FJM, van Amerongen G, Haagmans BL, Enjuanes L, Osterhaus ADME, Grosveld F, Bosch BJ. An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern. Sci Immunol. 2022 Jul 29;7(73):eabp9312. doi: 10.1126/sciimmunol.abp9312. Epub 2022 Jul 29. PMID: 35471062; PMCID: PMC9097884.
HPV Type-Specific Distribution Among Family Members and Linen in Households of Cutaneous Wart Patients	2022	Publication		J Eur Acad Dermatol Venereol	Virology	Ghorzang E, de Koning MNC, Bouwes Bavinck JN, Gussekloo J, Quint KD, Goeman JJ, Feltkamp MCW, Bruggink SC, Eekhof JAH. HPV type-specific distribution among family members and linen in households of cutaneous wart patients. J Eur Acad Dermatol Venereol. 2022 Jan;36(1):119-125. doi: 10.1111/jdv.17684. Epub 2021 Oct 2. PMID: 34547117; PMCID: PMC9293406.
Evidence of Latent HPV Infection in Older Danish Women with a Previous History of Cervical Dysplasia	2022	Publication		Acta Obstet Gynecol Scand	Solid tumors	Hammer A, Blaakaer J, de Koning MNC, Steiniche T, Mejlgaard E, Svanholm H, Roensbo MT, Fuglsang K, Doorbar J, Andersen RH, Quint WGV, Gravitt PE. Evidence of latent HPV infection in older Danish women with a previous history of cervical dysplasia. Acta Obstet Gynecol Scand. 2022 Jun;101(6):608-615. doi: 10.1111/aogs.14362. Epub 2022 Apr 28. PMID: 35481603; PMCID: PMC9564550.
Communicating Regulatory High-Throughput Sequencing Data Using Biocompute Objects	2022	Publication		Drug Discov Today	Cross-therapeutic area	King CHS 4th, Keeney J, Guimera N, Das S, Weber M, Fochtman B, Walderhaug MO, Talwar S, Patel JA, Mazumder R, Donaldson EF. Communicating regulatory high- throughput sequencing data using BioCompute Objects. Drug Discov Today. 2022 Apr;27(4):1108-1114. doi: 10.1016/j.drudis.2022.01.007. Epub 2022 Jan 22. PMID: 35077912.
Concordance of p16 and E6*I Mrna Among HPV-DNA-Positive Oropharyngeal, Laryngeal, and Oral Cavity Carcinomas From the ICO International Study	2022	Publication		Cancers (Basel)	Solid tumors	Mena M, Wang X, Tous S, Quiros B, Clavero O, Alejo M, Morey F, Taberna M, Leon Vintro X, Lloveras Rubio B, Alos L, Mehanna H, Quint W, Pawlita M, Tommasino M, Pavón MA, Muñoz N, De Sanjose S, Bosch FX, Alemany L, On Behalf Of The Ico International Hpv In Head And Neck Cancer Study Group. Concordance of p16INK4a and E6*I mRNA among HPV-DNA-Positive Oropharyngeal, Laryngeal, and Oral Cavity Carcinomas from the ICO International Study. Cancers (Basel). 2022 Aug 4;14(15):3787. doi: 10.3390/cancers14153787. PMID: 35954451; PMCID: PMC9367257.
Topical Antimicrobial Peptide Omiganan Recovers Cutaneous Dysbiosis But Does Not Improve Clinical Symptoms in Patients with Mild to Moderate Atopic Dermatitis in a Phase 2 Randomized Controlled Trial	2022	Publication		J Am Acad Dermatol.	Infectious diseases	Niemeyer-van der Kolk T, Buters TP, Krouwels L, Boltjes J, de Kam ML, van der Wall H, van Alewijk DCJG, van den Munckhof EHA, Becker MJ, Feiss G, Florencia EF, Prens EP, Moerland M, Burggraaf J, Rissmann R, van Doorn MBA. Topical antimicrobial peptide omiganan recovers cutaneous dysbiosis but does not improve clinical symptoms in patients with mild to moderate atopic dermatitis in a phase 2 randomized controlled trial. J Am Acad Dermatol. 2022 Apr;86(4):854-862. doi: 10.1016/j.jaad.2020.08.132. Epub 2020 Oct 1. PMID: 33010325.
Results of a Randomized, Placebo-Controlled, First-in-Human Trial of Topical CY-002 in Patients with Cutaneous Warts	2022	Publication		J Eur Acad Dermatol Venereol	Virology	Pagan L, Yfanti C, Rijneveld R, Todd M, Jongste P, Feijen JJ, Klaassen ES, Bouwes Bavinck JN, Struijk L, de Koning MNC, Prestegarden L, Niemeyer-van der Kolk T, van Poelgeest MIE, Rissmann R. Results of a randomized, placebo-controlled, first-in-human trial of topical CY-002 in patients with cutaneous warts. J Eur Acad Dermatol Venereol. 2022 Oct;36(10):e773-e775. doi: 10.1111/jdv.18291. Epub 2022 Jun 14. PMID: 35699238.
Clinical Performance of the Full Genotyping Agena Massarray HPV Assay Using Surepath Screening Samples Within the VALGENT4 Framework	2022	Publication		J Mol Diagn	Virology	Pedersen H, Ejegod DM, Quint W, Xu L, Arbyn M, Bonde J. Clinical Performance of the Full Genotyping Agena MassARRAY HPV Assay Using SurePath Screening Samples within the VALGENT4 Framework. J Mol Diagn. 2022 Apr;24(4):365-373. doi: 10.1016/j.jmoldx.2021.12.009. Epub 2022 Feb 3. PMID: 35123039.
Analysis of Cervical HPV Infections Among Unvaccinated Young Adult Women to Inform Vaccine Strategies in This Age Group: The Costa Rica HPV Vaccine Trial	2022	Publication		Sex Transm Infect	Virology	Sierra MS, Tsang SH, Porras C, Herrero R, Sampson JN, Cortes B, Schussler J, Wagner S, Carvajal L, Quint W, Kreimer AR, Hu S, Rodriguez AC, Romero B, Hildesheim A; Costa Rica HPV Vaccine Trial (CVT) Group. Analysis of cervical HPV infections among unvaccinated young adult women to inform vaccine strategies in this age group: the Costa Rica HPV Vaccine Trial. Sex Transm Infect. 2022 Jul 16;99(3):180–6. doi: 10.1136/sextrans-2022-055434. Epub ahead of print. PMID: 35842229; PMCID: PMC10176398.
Association of Plasma Circulating Tumor HPV DNA with HPV-Related Oropharynx Cancer	2022	Publication		JAMA Otolaryngol Head Neck Surg	Solid tumors	Tewari SR, D'Souza G, Troy T, Wright H, Struijk L, Waterboer T, Fakhry C. Association of Plasma Circulating Tumor HPV DNA With HPV-Related Oropharynx Cancer. JAMA Otolaryngol Head Neck Surg. 2022 May 1;148(5):488-489. doi: 10.1001/jamaoto.2022.0159. PMID: 35323891; PMCID: PMC8949748.
The Relationship Between Vaginal Ph and Bacterial Vaginosis as Diagnosed Using Qpcr in an Asymptomatic Subfertile Population	2022	Publication		Arch Gynecol Obstet	Infectious diseases	van den Tweel MM, van der Struijs S, van den Munckhof EHA, Boers KE. The relationship between vaginal pH and bacterial vaginosis as diagnosed using qPCR in an asymptomatic subfertile population. Arch Gynecol Obstet. 2022 Nov;306(5):1787-1793. doi: 10.1007/s00404-022-06764-1. Epub 2022 Sep 9. PMID: 36083500.
Performance of DNA Methylation Analysis of ASCL1, LHX8, ST6GALNAC5, GHSR, ZIC1 and SST for the Triage of HPV-Positive Women: Results From a Dutch Primary HPV-Based Screening Cohort	2022	Publication		Int J Cancer	Virology	Verhoef L, Bleeker MCG, Polman N, Steenbergen RDM, Meijer CJLM, Melchers WJG, Bekkers RL, Molijn AC, Quint WG, van Kemenade FJ, Berkhof J, Heideman DAM. Performance of DNA methylation analysis of ASCL1, LHX8, ST6GALNAC5, GHSR, ZIC1 and SST for the triage of HPV-positive women: Results from a Dutch primary HPV- based screening cohort. Int J Cancer. 2022 Feb 1;150(3):440-449. doi: 10.1002/ijc.33820. Epub 2021 Oct 13. PMID: 34558659; PMCID: PMC9293097.
Evaluating Stability of Attenuated Sabin and Two Novel Type 2 Oral Poliovirus Vaccines in Children	2022	Publication		NPJ Vaccines	Virology	Wahid R, Mercer L, Gast C, De Leon T, Sáez-Llorens X, Fix A, Macadam A, Stephens L, Chumakov K, Smits SL, Murreddu M, Konopka-Anstadt JL, Steven Oberste M, Burns CC, Andino R, Bachtiar NS, Tritama E, Bandyopadhyay AS, Aguirre G, Rüttimann R, Konz JO. Evaluating stability of attenuated Sabin and two novel type 2 oral poliovirus vaccines in children. NPJ Vaccines. 2022 Feb 11;7(1):19. doi: 10.1038/s41541-022-00437-5. PMID: 35149714; PMCID: PMC8837630.
Genetic and Phenotypic Stability of Poliovirus Shed From Infants Who Received Novel Type 2 or Sabin Type 2 Oral Poliovirus Vaccines in Panama: An Analysis of Two Clinical Trials	2022	Publication		Lancet Microbe	Virology	Wahid R, Mercer LD, De Leon T, DeAntonio R, Sáez-Llorens X, Macadam A, Chumakov K, Strating J, Koel B, Konopka-Anstadt JL, Oberste MS, Burns CC, Andino R, Tritama E, Bandyopadhyay AS, Aguirre G, Rüttimann R, Gast C, Konz JO. Genetic and phenotypic stability of poliovirus shed from infants who received novel type 2 or Sabin type 2 oral poliovirus vaccines in Panama: an analysis of two clinical trials. Lancet Microbe. 2022 Dec;3(12):e912-e921. doi: 10.1016/S2666-5247(22)00254-3. Epub 2022 Nov 1. PMID: 36332645; PMCID: PMC9712124.
Stenoparib, an Inhibitor of Cellular Poly (ADP-Ribose) Polymerases (parps), Blocks in Vitro Replication of SARS-Cov-2 Variants	2022	Publication		PLoS One	Virology	Zarn KE, Jaramillo SA, Zapata AR, Stone NE, Jones AN, Nunnally HE, Settles EW, Ng K, Keim PS, Knudsen S, Nuijten PM, Tijsma ASL, French CT. Stenoparib, an inhibitor of cellular poly (ADP-ribose) polymerases (PARPs), blocks in vitro replication of SARS-CoV-2 variants. PLoS One. 2022 Sep 14;17(9):e0272916. doi: 10.1371/journal.pone.0272916. PMID: 36103462; PMCID: PMC9473406.
Performance of Cervical Screening a Decade Following HPV Vaccination: The Costa Rica Vaccine Trial	2022	Publication		J Natl Cancer Inst	Virology	Hu SY, Kreimer AR, Porras C, Guillén D, Alfaro M, Darragh TM, Stoler MH, Villegas LF, Ocampo R, Rodriguez AC, Schiffman M, Tsang SH, Lowy DR, Schiller JT, Schussler J, Quint W, Gail MH, Sampson JN, Hildesheim A, Herrero R; Costa Rica HPV Vaccine Trial (CVT) Group. Performance of Cervical Screening a Decade Following HPV Vaccination: The Costa Rica Vaccine Trial. J Natl Cancer Inst. 2022 Sep 9;114(9):1253-1261. doi: 10.1093/jnci/djac107. PMID: 35640980; PMCID: PMC9468298.
Dynamics of Circulating Calprotectin Accurately Predict the Outcome of Moderate COVID-19 Patients	2022	Publication		eBioMedicine	Infectious diseases	Nicolas Chapuis, Nusaibah Ibrahimi, Thibaut Belmondo, Claire Goulvestre, Anne-Emmanuelle Berger, Alice-Andrée Mariaggi, Muriel Andrieu, Camille Chenevier-Gobeaux, Arnaud Bayle, Lydia Campos, Cherifa Cheurfa, Richard Chocron, Jean-Luc Diehl, Benoît Doumenc, Jérôme Duchemin, Manon Duprat, Fabien François, Nicolas Gendron, Tristant Mirault, Frédéric Pène, Aurélien Philippe, Fanny Pommeret, Olivier Sanchez, David M. Smadja, Tali-Anne Szwebel, Aymeric Silvin, Florent Ginhoux, Ludovic Lacroix, Gérôme Jules-Clément, Sarobidy Rapeteramana, Colette Maviera, Laura Stellera, Barbara Perniconi, Fabrice André, Damien Drubay, Michaela Fontenay, Sophie Hüe, Stéphane Paul, Eric Solary
Prevalence of SARS-Cov-2 Antibodies in France: Results From Nationwide Serological Surveillance	2021	Publication		Nat Commun	Virology	Le Vu S, Jones G, Anna F, Rose T, Richard JB, Bernard-Stoecklin S, Goyard S, Demeret C, Helynck O, Escriou N, Gransagne M, Petres S, Robin C, Monnet V, Perrin de Facci L, Ungeheuer MN, Léon L, Guillois Y, Filleul L, Charneau P, Lévy-Bruhl D, van der Werf S, Noel H. Prevalence of SARS-CoV-2 antibodies in France: results from nationwide serological surveillance. Nat Commun. 2021 May 21;12(1):3025. doi: 10.1038/s41467-021-23233-6. PMID: 34021152; PMCID: PMC8140151.
Protective Efficacy of a Polyvalent Influenza A DNA Vaccine Against Both Homologous (H1N1pdm09) and Heterologous (H5N1) Challenge in the Ferret Model	2021	Publication		Vaccine	Virology	Guilfoyle K, Major D, Skeldon S, James H, Tingstedt JL, Polacek C, Lassauniére R, Engelhardt OG, Fomsgaard A. Protective efficacy of a polyvalent influenza A DNA vaccine against both homologous (H1N1pdm09) and heterologous (H5N1) challenge in the ferret model. Vaccine. 2021 Aug 9;39(34):4903-4913. doi: 10.1016/j.vaccine.2020.09.062. Epub 2020 Oct 6. PMID: 33036805.
Flow Cytometric Method Transfer: Recommendations for Best Practice	2021	Publication		Cytometry B Clin Cytom	Cross-therapeutic area	Cabanski M, Oldaker T, Stewart JJ, Selliah N, Eck S, Green C, Litwin V, Vitaliti A. Flow cytometric method transfer: Recommendations for best practice. Cytometry B Clin Cytom. 2021 Jan;100(1):52-62. doi: 10.1002/cyto.b.21971. Epub 2020 Nov 18. PMID: 33207038.
Evaluation of Harmoniahpv Test for Detection of Clinically Significant Human Papillomavirus Infection Using the VALGENT Framework	2021	Publication		J Virol Methods	Virology	Bhatia R, Boada EA, Bonde J, Quint W, Christiansen IK, Xu L, Ejegod DM, Moncur S, Cuschieri K, Arbyn M. Evaluation of HarmoniaHPV test for detection of clinically significant Human Papillomavirus infection using the VALGENT framework. J Virol Methods. 2021 Aug;294:114161. doi: 10.1016/j.jviromet.2021.114161. Epub 2021 Apr 22. PMID: 33895238.
Methylation Markers FAM19A4 and miR124-2 as Triage Strategy for Primary Human Papillomavirus Screen Positive Women: A Large European Multicenter Study	2021	Publication		Int J Cancer	Virology	Bonde J, Floore A, Ejegod D, Vink FJ, Hesselink A, van de Ven PM, Valenčak AO, Pedersen H, Doorn S, Quint WG, Petry KU, Poljak M, Stanczuk G, Cuschieri K, de Sanjosé S, Bleeker M, Berkhof J, Meijer CJLM, Heideman DAM. Methylation markers FAM19A4 and miR124-2 as triage strategy for primary human papillomavirus screen positive women: A large European multicenter study. Int J Cancer. 2021 Jan 15;148(2):396-405. doi: 10.1002/ijc.33320. Epub 2020 Oct 21. PMID: 32997803; PMCID: PMC7756277.
Relationship of Human Papillomavirus with Seborrheic Keratosis of the Female Genital Tract - a Case-Series and Literature Review	2021	Publication		Histol Histopathol	Virology	Dasgupta S, van Eersel R, Morrel B, van den Munckhof HAM, de Geus VA, van der Hoeven NMA, van de Sandt MM, Piso-Jozwiak M, Quint WGV, van der Avoort IAM, Koljenović S, Ewing-Graham PC, van Kemenade FJ. Relationship of human papillomavirus with seborrheic keratosis of the female genital tract - a case- series and literature review. Histol Histopathol. 2021 Dec;36(12):1209-1218. doi: 10.14670/HH-18-357. Epub 2021 May 25. PMID: 34170001.
HPV Vaccination to Prevent Recurrence of Anal Intraepithelial Neoplasia in HIV+ MSM	2021	Publication		AIDS	Solid tumors	Gosens KCM, van der Zee RP, van Heukelom MLS, Jongen VW, Cairo I, van Eeden A, van Noesel CJM, Quint WGV, Pasmans H, Dijkgraaf MGW, de Vries HJC, Prins JM. HPV vaccination to prevent recurrence of anal intraepithelial neoplasia in HIV+ MSM. AIDS. 2021 Sep 1;35(11):1753-1764. doi: 10.1097/QAD.0000000000002928. PMID: 33966029; PMCID: PMC8373452.
Transient CRISPR-Cas Treatment Can Prevent Reactivation of HIV-1 Replication in a Latently Infected T-Cell Line	2021	Publication		Viruses	Virology	Liu Y, Jeeninga RE, Klaver B, Berkhout B, Das AT. Transient CRISPR-Cas Treatment Can Prevent Reactivation of HIV-1 Replication in a Latently Infected T-Cell Line. Viruses. 2021 Dec 8;13(12):2461. doi: 10.3390/v13122461. PMID: 34960730; PMCID: PMC8705111.
Preclinical Development of a Molecular Clamp-Stabilised Subunit Vaccine for Severe Acute Respiratory Syndrome Coronavirus 2	2021	Publication		Clin Transl Immunology	Virology	Watterson D, Wijesundara DK, Modhiran N, Mordant FL, Li Z, Avumegah MS, McMillan CL, Lackenby J, Guilfoyle K, van Amerongen G, Stittelaar K, Cheung ST, Bibby S, Daleris M, Hoger K, Gillard M, Radunz E, Jones ML, Hughes K, Hughes B, Goh J, Edwards D, Scoble J, Pearce L, Kowalczyk L, Phan T, La M, Lu L, Pham T, Zhou Q, Brockman DA, Morgan SJ, Lau C, Tran MH, Tapley P, Villalón-Letelier F, Barnes J, Young A, Jaberolansar N, Scott CA, Isaacs A, Amarilla AA, Khromykh AA, van den Brand JM, Reading PC, Ranasinghe C, Subbarao K, Munro TP, Young PR, Chappell KJ. Preclinical development of a molecular clamp-stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2. Clin Transl Immunology. 2021 Apr 5;10(4):e1269. doi: 10.1002/cti2.1269. PMID: 33841880; PMCID: PMC8021130.
Development of Molecular Clamp Stabilized Hemagglutinin Vaccines for Influenza A Viruses	2021	Publication		NPJ Vaccines	Virology	McMillan CLD, Cheung STM, Modhiran N, Barnes J, Amarilla AA, Bielefeldt-Ohmann H, Lee LYY, Guilfoyle K, van Amerongen G, Stittelaar K, Jakob V, Lebas C, Reading P, Short KR, Young PR, Watterson D, Chappell KJ. Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses. NPJ Vaccines. 2021 Nov 8;6(1):135. doi: 10.1038/s41541-021-00395-4. Erratum in: NPJ Vaccines. 2022 Jan 5;7(1):3. PMID: 34750396; PMCID: PMC8575991.
The in Vitro and in Vivo Efficacy of CT-P59 Against Gamma, Delta and Its Associated Variants of SARS-Cov-2	2021	Publication		Biochem Biophys Res Commun	Virology	Ryu DK, Kang B, Noh H, Woo SJ, Lee MH, Nuijten PM, Kim JI, Seo JM, Kim C, Kim M, Yang E, Lim G, Kim SG, Eo SK, Choi JA, Song M, Oh SS, Chung HY, Tijsma AS, van Baalen CA, Kwon KS, Lee SY. The in vitro and in vivo efficacy of CT-P59 against Gamma, Delta and its associated variants of SARS-CoV-2. Biochem Biophys Res Commun. 2021 Nov 12;578:91-96. doi: 10.1016/j.bbrc.2021.09.023. Epub 2021 Sep 13. PMID: 34547629; PMCID: PMC8436435.
The Prevalence of Human Leucocyte Antigen and Human Papillomavirus DNA in Penile Intraepithelial Neoplasia in England 2011–2012	2021	Publication		Int J STD AIDS	Solid tumors	Shim TN, Harwood CA, Marsh SG, Gotch FM, Quint W, de Koning MN, Francis N, Jameson C, Freeman A, Minhas S, Muneer A, Dinneen M, Bunker CB. The prevalence of human leucocyte antigen and human papillomavirus DNA in penile intraepithelial neoplasia in England 2011-2012. Int J STD AIDS. 2021 Apr;32(5):388-395. doi: 10.1177/0956462420970727. Epub 2021 Feb 12. PMID: 33576716.
Risk Factors for Non–Human Papillomavirus (HPV) Type 16/18 Cervical Infections and Associated Lesions Among HPV DNA–Negative Women Vaccinated Against HPV-16/18 in the Costa Rica Vaccine Trial	2021	Publication		J Infect Dis	Virology	Sierra MS, Tsang SH, Hu S, Porras C, Herrero R, Kreimer AR, Schussler J, Boland J, Wagner S, Cortes B, Rodríguez AC, Quint W, van Doorn LJ, Schiffman M, Sampson JN, Hildesheim A; Costa Rica Human Papillomavirus Vaccine Trial (CVT) Group. Risk Factors for Non-Human Papillomavirus (HPV) Type 16/18 Cervical Infections and Associated Lesions Among HPV DNA-Negative Women Vaccinated Against HPV-16/18 in the Costa Rica Vaccine Trial. J Infect Dis. 2021 Aug 2;224(3):503-516. doi: 10.1093/infdis/jiaa768. PMID: 33326576; PMCID: PMC8496490.
Efficacy of AS04-Adjuvanted Vaccine Against Human Papillomavirus (HPV) Types 16 and 18 in Clearing Incident HPV Infections: Pooled Analysis of Data From the Costa Rica Vaccine Trial and the PATRICIA Study	2021	Publication		J Infect Dis	Virology	Tota JE, Struyf F, Hildesheim A, Gonzalez P, Ryser M, Herrero R, Schussler J, Karkada N, Rodriguez AC, Folschweiller N, Porras C, Schiffman M, Schiller JT, Quint W, Kreimer AR, Lehtinen M, Wheeler CM, Sampson JN. Efficacy of AS04-Adjuvanted Vaccine Against Human Papillomavirus (HPV) Types 16 and 18 in Clearing Incident HPV Infections: Pooled Analysis of Data From the Costa Rica Vaccine Trial and the PATRICIA Study. J Infect Dis. 2021 May 20;223(9):1576-1581. doi: 10.1093/infdis/jiaa561. PMID: 32887990; PMCID: PMC8248553.
Developing an Algorithm for the Diagnosis of Abnormal Vaginal Discharge in a Dutch Clinical Setting: A Pilot Study	2021	Publication		Diagn Microbiol Infect Dis	Solid tumors	van den Munckhof EHA, van Sitter RL, Lamont RF, le Cessie S, Kuijper EJ, Knetsch CW, Molijn A, Quint WGV, Boers KE, Leverstein-van Hall MA. Developing an algorithm for the diagnosis of abnormal vaginal discharge in a dutch clinical setting: a pilot study. Diagn Microbiol Infect Dis. 2021 Sep;101(1):115431. doi: 10.1016/j.diagmicrobio.2021.115431. Epub 2021 May 17. PMID: 34153570.
Characterisation of Anal Intraepithelial Neoplasia and Anal Cancer in HIV-Positive Men by Immunohistochemical Markers p16, Ki-67, HPV-E4 and DNA Methylation Markers	2021	Publication		Int J Cancer	Solid tumors	van der Zee RP, Meijer CJLM, Cuming T, Kreuter A, van de Sandt MM, Quint WGV, de Vries HJC, Prins JM, Steenbergen RDM. Characterisation of anal intraepithelial neoplasia and anal cancer in HIV-positive men by immunohistochemical markers p16, Ki-67, HPV-E4 and DNA methylation markers. Int J Cancer. 2021 Nov 15;149(10):1833-1844. doi: 10.1002/ijc.33748. Epub 2021 Aug 4. PMID: 34310698; PMCID: PMC9292283.
Cancer Risk Stratification of Anal Intraepithelial Neoplasia in Human Immunodeficiency Virus–Positive Men by Validated Methylation Markers Associated with Progression to Cancer	2021	Publication		Clin Infect Dis	Solid tumors	van der Zee RP, Richel O, van Noesel CJM, Ciocănea-Teodorescu I, van Splunter AP, Ter Braak TJ, Nathan M, Cuming T, Sheaff M, Kreuter A, Meijer CJLM, Quint WGV, de Vries HJC, Prins JM, Steenbergen RDM. Cancer Risk Stratification of Anal Intraepithelial Neoplasia in Human Immunodeficiency Virus-Positive Men by Validated Methylation Markers Associated With Progression to Cancer. Clin Infect Dis. 2021 Jun 15;72(12):2154-2163. doi: 10.1093/cid/ciaa397. PMID: 32266940; PMCID: PMC8204787.
Lower Respiratory Tract Infection in the Community: Associations Between Viral Aetiology and Illness Course	2021	Publication		Clin Microbiol Infect	Virology	Vos LM, Bruyndonckx R, Zuithoff NPA, Little P, Oosterheert JJ, Broekhuizen BDL, Lammens C, Loens K, Viveen M, Butler CC, Crook D, Zlateva K, Goossens H, Claas ECJ, Ieven M, Van Loon AM, Verheij TJM, Coenjaerts FEJ; GRACE Consortium. Lower respiratory tract infection in the community: associations between viral aetiology and illness course. Clin Microbiol Infect. 2021 Jan;27(1):96-104. doi: 10.1016/j.cmi.2020.03.023. Epub 2020 Mar 31. PMID: 32244051; PMCID: PMC7118666.
Balanopreputial Sac and Urine Microbiota in Patients with Male Genital Lichen Sclerosus	2021	Publication		Int J Dermatol	Infectious diseases	Watchorn RE, van den Munckhof EHA, Quint KD, Eliahoo J, de Koning MNC, Quint WGV, Bunker CB. Balanopreputial sac and urine microbiota in patients with male genital lichen sclerosus. Int J Dermatol. 2021 Feb;60(2):201-207. doi: 10.1111/ijd.15252. Epub 2020 Oct 20. PMID: 33084022.
The Vaginal Microbiota in the Course of Bacterial Vaginosis Treatment	2021	Publication		Eur J Clin Microbiol Infect Dis	Infectious diseases	Zwittink RD, van den Munckhof EHA, Leverstein-van Hall MA, Boers K, Molijn A, Knetsch CW, Kuijper EJ. The vaginal microbiota in the course of bacterial vaginosis treatment. Eur J Clin Microbiol Infect Dis. 2021 Mar;40(3):651-656. doi: 10.1007/s10096-020-04049-6. Epub 2020 Oct 7. PMID: 33029765; PMCID: PMC7892685.
Susceptibility of Rabbits to SARS-Cov-2	2021	Publication		Emerg Microbes Infect	Virology	Mykytyn AZ, Lamers MM, Okba NMA, Breugem TI, Schipper D, van den Doel PB, van Run P, van Amerongen G, de Waal L, Koopmans MPG, Stittelaar KJ, van den Brand JMA, Haagmans BL. Susceptibility of rabbits to SARS-CoV-2. Emerg Microbes Infect. 2021 Dec;10(1):1-7. doi: 10.1080/22221751.2020.1868951. PMID: 33356979; PMCID: PMC7832544.
Therapeutic Effect of CT-P59 Against SARS-Cov-2 South African Variant	2021	Publication		Biochem Biophys Res Commun	Virology	Ryu DK, Song R, Kim M, Kim YI, Kim C, Kim JI, Kwon KS, Tijsma AS, Nuijten PM, van Baalen CA, Hermanus T, Kgagudi P, Moyo-Gwete T, Moore PL, Choi YK, Lee SY. Therapeutic effect of CT-P59 against SARS-CoV-2 South African variant. Biochem Biophys Res Commun. 2021 Aug 20;566:135-140. doi: 10.1016/j.bbrc.2021.06.016. Epub 2021 Jun 7. PMID: 34119826; PMCID: PMC8180667.
Assessment of Genetic Changes and Neurovirulence of Shed Sabin and Novel Type 2 Oral Polio Vaccine Viruses	2021	Publication		NPJ Vaccines	Virology	Wahid R, Mercer L, Macadam A, Carlyle S, Stephens L, Martin J, Chumakov K, Laassri M, Petrovskaya S, Smits SL, Stittelaar KJ, Gast C, Weldon WC, Konopka-Anstadt JL, Steven Oberste M, Van Damme P, De Coster I, Rüttimann R, Bandyopadhyay A, Konz J. Assessment of genetic changes and neurovirulence of shed Sabin and novel type 2 oral polio vaccine viruses. NPJ Vaccines. 2021 Jul 29;6(1):94. doi: 10.1038/s41541-021-00355-y. PMID: 34326330; PMCID: PMC8322168.
AS03-Adjuvanted H7N9 Inactivated Split Virion Vaccines Induce Cross-Reactive and Protective Responses in Ferrets	2021	Publication		NPJ Vaccines	Virology	Stadlbauer D, Waal L, Beaulieu E, Strohmeier S, Kroeze EJBV, Boutet P, Osterhaus ADME, Krammer F, Innis BL, Nachbagauer R, Stittelaar KJ, Mallett CP. AS03-adjuvanted H7N9 inactivated split virion vaccines induce cross-reactive and protective responses in ferrets. NPJ Vaccines. 2021 Mar 19;6(1):40. doi: 10.1038/s41541-021-00299-3. PMID: 33742000; PMCID: PMC7979725.
Evaluation and Validation of Next-Generation Sequencing to Support Lot Release for a Novel Type 2 Oral Poliovirus Vaccine	2021	Publication		Vaccine X	Virology	Konz JO, Schofield T, Carlyle S, Wahid R, Ansari A, Strating JRPM, Yeh MT, Manukyan H, Smits SL, Tritama E, Rahmah L, Ugiyadi D, Andino R, Laassri M, Chumakov K, Macadam A. Evaluation and validation of next-generation sequencing to support lot release for a novel type 2 oral poliovirus vaccine. Vaccine X. 2021 Jun 11;8:100102. doi: 10.1016/j.jvacx.2021.100102. PMID: 34195600; PMCID: PMC8233139.
Ad26.COV2.S Protects Syrian Hamsters Against G614 Spike Variant SARS-Cov-2 and Does Not Enhance Respiratory Disease	2021	Publication		NPJ Vaccines	Virology	van der Lubbe JEM, Rosendahl Huber SK, Vijayan A, Dekking L, van Huizen E, Vreugdenhil J, Choi Y, Baert MRM, Feddes-de Boer K, Izquierdo Gil A, van Heerden M, Dalebout TJ, Myeni SK, Kikkert M, Snijder EJ, de Waal L, Stittelaar KJ, Tolboom JTBM, Serroyen J, Muchene L, van der Fits L, Rutten L, Langedijk JPM, Barouch DH, Schuitemaker H, Zahn RC, Wegmann F. Ad26.COV2.S protects Syrian hamsters against G614 spike variant SARS-CoV-2 and does not enhance respiratory disease. NPJ Vaccines. 2021 Mar 19;6(1):39. doi: 10.1038/s41541-021-00301-y. PMID: 33741993; PMCID: PMC7979827.
Human Milk From Previously COVID-19-Infected Mothers: The Effect of Pasteurization on Specific Antibodies and Neutralization Capacity	2021	Publication		Nutrients	Virology	van Keulen BJ, Romijn M, Bondt A, Dingess KA, Kontopodi E, van der Straten K, den Boer MA, Burger JA, Poniman M, Bosch BJ, Brouwer PJM, de Groot CJM, Hoek M, Li W, Pajkrt D, Sanders RW, Schoonderwoerd A, Tamara S, Timmermans RAH, Vidarsson G, Stittelaar KJ, Rispens TT, Hettinga KA, van Gils MJ, Heck AJR, van Goudoever JB. Human Milk from Previously COVID-19-Infected Mothers: The Effect of Pasteurization on Specific Antibodies and Neutralization Capacity. Nutrients. 2021 May 13;13(5):1645. doi: 10.3390/nu13051645. PMID: 34068142; PMCID: PMC8152997.
Prevalence of SARS-Cov-2 Antibodies in France: Results From Nationwide Serological Surveillance	2021	Publication		Nature Communications	Infectious diseases	Gabrielle Jones, Stéphane Le Vu, Sibylle Bernard-Stoecklin, Sophie Goyard, Caroline Demeret, François Anna, Thierry Rose, Jean-Baptiste Richard, Olivier Helynck, Nicolas Escriou, Marion Gransagne, Stéphane Petres, Corinne Robin, Virgile Monnet, Louise Perrin de Facci, Marie-Noelle Ungeheuer, Lucie Léon, Yvonnick Guillois, Laurent Filleul, Pierre Charneau, Daniel Lévy-Bruhl, Sylvie van der Werf, Harold Noel
16S Rrna Gene Profiling: Direct and Indirect Applications for Clinical Microbiology	2020	Publication		Leiden University (Scholarly Publications)	Infectious diseases	Munckhof, EHA van den. 16S rRNA gene profiling: Direct and indirect applications for clinical microbiology. Thesis 2020
Human Papillomavirus 16–Positive Supraclavicular Cutaneous Squamous Cell Carcinoma Metastatic to the Level IV Supraclavicular Lymph Nodes	2020	Publication		JAAD Case Rep	Solid tumors	Dekker H, Bun RJ, Mulder DC, Breeuwsma N, van der Rhee JI, Guimerà N, Quint W, Vermeer MH, Bouwes Bavinck JN. Human papillomavirus 16-positive supraclavicular cutaneous squamous cell carcinoma metastatic to the level IV supraclavicular lymph nodes. JAAD Case Rep. 2020 Jul 11;6(9):822-825. doi: 10.1016/j.jdcr.2020.07.002. PMID: 32875029; PMCID: PMC7452168.
Letermovir Resistance Analysis in a Clinical Trial of Cytomegalovirus Prophylaxis for Hematopoietic Stem Cell Transplant Recipients	2020	Publication		J Infect Dis	Virology	Douglas CM, Barnard R, Holder D, Leavitt R, Levitan D, Maguire M, Nickle D, Teal V, Wan H, van Alewijk DCJG, van Doorn LJ, Chou S, Strizki J. Letermovir Resistance Analysis in a Clinical Trial of Cytomegalovirus Prophylaxis for Hematopoietic Stem Cell Transplant Recipients. J Infect Dis. 2020 Mar 16;221(7):1117-1126. doi: 10.1093/infdis/jiz577. PMID: 31781762; PMCID: PMC7075417.
Long-Term Persistence of Oral HPV Over 7 Years of Follow-Up	2020	Publication		JNCI Cancer Spectr	Virology	D'Souza G, Clemens G, Strickler HD, Wiley DJ, Troy T, Struijk L, Gillison M, Fakhry C. Long-term Persistence of Oral HPV Over 7 Years of Follow-up. JNCI Cancer Spectr. 2020 Jun 5;4(5):pkaa047. doi: 10.1093/jncics/pkaa047. PMID: 33225205; PMCID: PMC7667996.
Comparison of Human Papillomavirus Genotypes in Penile Intraepithelial Neoplasia and Associated Lesions: LCM-PCR Study of 87 Lesions in 8 Patients	2020	Publication		Int J Surg Pathol	Solid tumors	Fernández-Nestosa MJ, Guimerà N, Sanchez DF, Cañete-Portillo S, Lobatti A, Velazquez EF, Jenkins D, Quint W, Cubilla AL. Comparison of Human Papillomavirus Genotypes in Penile Intraepithelial Neoplasia and Associated Lesions: LCM-PCR Study of 87 Lesions in 8 Patients. Int J Surg Pathol. 2020 May;28(3):265-272. doi: 10.1177/1066896919887802. Epub 2019 Nov 17. PMID: 31735112.
Molecular and Pathological Basis of HPV-Negative Cervical Adenocarcinoma Seen in a Global Study	2020	Publication		Int J Cancer	Solid tumors	Jenkins D, Molijn A, Kazem S, Pirog EC, Alemany L, de Sanjosé S, Dinjens W, Quint W. Molecular and pathological basis of HPV-negative cervical adenocarcinoma seen in a global study. Int J Cancer. 2020 Nov 1;147(9):2526-2536. doi: 10.1002/ijc.33124. Epub 2020 Jul 6. PMID: 32474915.
Recent Advances in Cultivation-Independent Molecular-Based Techniques for the Characterization of Vaginal Eubiosis and Dysbiosis	2020	Publication		Fac Rev	Infectious diseases	Lamont RF, van den Munckhof EH, Luef BM, Vinter CA, Jørgensen JS. Recent advances in cultivation-independent molecular-based techniques for the characterization of vaginal eubiosis and dysbiosis. Fac Rev. 2020 Dec 9;9:21. doi: 10.12703/r/9-21. PMID: 33659953; PMCID: PMC7886079.
Expression of p16 and HPV E4 on Biopsy Samples and Methylation of FAM19A4 and miR124-2 on Cervical Cytology Samples in the Classification of Cervical Squamous Intraepithelial Lesions	2020	Publication		Cancer Med	Solid tumors	Leeman A, Jenkins D, Del Pino M, Ordi J, Torné A, Doorbar J, Meijer CJLM, van Kemenade FJ, Quint WGV. Expression of p16 and HPV E4 on biopsy samples and methylation of FAM19A4 and miR124-2 on cervical cytology samples in the classification of cervical squamous intraepithelial lesions. Cancer Med. 2020 Apr;9(7):2454-2461. doi: 10.1002/cam4.2855. Epub 2020 Feb 5. PMID: 32022461; PMCID: PMC7131853.
Grading Immunohistochemical Markers p16INK4a and HPV E4 Identifies Productive and Transforming Lesions Caused by Low‐ and High‐risk HPV Within High‐grade Anal Squamous Intraepithelial Lesions	2020	Publication		Br J Dermatol	Solid tumors	Leeman A, Jenkins D, Marra E, van Zummeren M, Pirog EC, van de Sandt MM, van Eeden A, Schim van der Loeff MF, Doorbar J, de Vries HJC, van Kemenade FJ, Meijer CJLM, Quint WGV. Grading immunohistochemical markers p16INK4a and HPV E4 identifies productive and transforming lesions caused by low- and high-risk HPV within high-grade anal squamous intraepithelial lesions. Br J Dermatol. 2020 Apr;182(4):1026-1033. doi: 10.1111/bjd.18342. Epub 2019 Oct 2. PMID: 31302935; PMCID: PMC7187351.
Pharmacodynamic Effects of Topical Omiganan in Patients with Mild to Moderate Atopic Dermatitis in a Randomized, Placebo-Controlled, Phase II Trial	2020	Publication		Clin Transl Sci	Inflammation and immunology	Niemeyer-van der Kolk T, van der Wall H, Hogendoorn GK, Rijneveld R, Luijten S, van Alewijk DCJG, van den Munckhof EHA, de Kam ML, Feiss GL, Prens EP, Burggraaf J, Rissmann R, van Doorn MBA. Pharmacodynamic Effects of Topical Omiganan in Patients With Mild to Moderate Atopic Dermatitis in a Randomized, Placebo-Controlled, Phase II Trial. Clin Transl Sci. 2020 Sep;13(5):994-1003. doi: 10.1111/cts.12792. Epub 2020 May 1. PMID: 32315497; PMCID: PMC7485951.
Efficacy of the Bivalent HPV Vaccine Against HPV 16/18-Associated Precancer: Long-Term Follow-Up Results From the Costa Rica Vaccine Trial	2020	Publication		Lancet Oncol	Solid tumors	Porras C, Tsang SH, Herrero R, Guillén D, Darragh TM, Stoler MH, Hildesheim A, Wagner S, Boland J, Lowy DR, Schiller JT, Schiffman M, Schussler J, Gail MH, Quint W, Ocampo R, Morales J, Rodríguez AC, Hu S, Sampson JN, Kreimer AR; Costa Rica Vaccine Trial Group. Efficacy of the bivalent HPV vaccine against HPV 16/18-associated precancer: long-term follow-up results from the Costa Rica Vaccine Trial. Lancet Oncol. 2020 Dec;21(12):1643-1652. doi: 10.1016/S1470-2045(20)30524-6. PMID: 33271093; PMCID: PMC8724969.
HPV-Independent Precursors Mimicking High-Grade Squamous Intraepithelial Lesions (HSIL) of the Vulva	2020	Publication		Am J Surg Pathol	Solid tumors	Rakislova N, Alemany L, Clavero O, Del Pino M, Saco A, Marimon L, Quirós B, Lloveras B, Ribera-Cortada I, Alejo M, Pawlita M, Quint W, de Sanjose S, Ordi J; VVAP Study Group. HPV-independent Precursors Mimicking High-grade Squamous Intraepithelial Lesions (HSIL) of the Vulva. Am J Surg Pathol. 2020 Nov;44(11):1506-1514. doi: 10.1097/PAS.0000000000001540. PMID: 32657782.
p53 Immunohistochemical Patterns in HPV-Independent Squamous Cell Carcinomas of the Vulva and the Associated Skin Lesions: A Study of 779 Cases	2020	Publication		Int J Molecular Science	Solid tumors	Rakislova N, Alemany L, Clavero O, Saco A, Torné A, del Pino, M, Munmany M, Rogdrigo-Calvo MT, Guerrero J, Marimon L, Vega N, Quirós B, Lloveras B, Ribera-Cortada I, Alejo M, Pawlita M, Quint W, de Sanjose, S, Ordi J, VVAP Study Group. p53 immunohistochemical patterns in HPV-independent squamous cell carcinomas of the vulva and the associated skin lesions: a study of 779 cases. Int J Molecular Sciences 2020 Oct 29;21(21):8091. doi: 10.3390/ijms21218091.
Results of Phase 2 Trials Exploring the Safety and Efficacy of Omiganan in Patients with Human Papillomavirus-Induced Genital Lesions	2020	Publication		Br J Clin Pharmacol	Solid tumors	Rijsbergen M, Rijneveld R, Todd M, Feiss GL, Kouwenhoven STP, Quint KD, van Alewijk DCJG, de Koning MNC, Klaassen ES, Burggraaf J, Rissmann R, van Poelgeest MIE. Results of phase 2 trials exploring the safety and efficacy of omiganan in patients with human papillomavirus-induced genital lesions. Br J Clin Pharmacol. 2020 Nov;86(11):2133-2143. doi: 10.1111/bcp.14181. Epub 2020 Sep 28. PMID: 31755993; PMCID: PMC7576619.
No Effect of Topical Digoxin and Furosemide Gel for Patients with External Anogenital Warts	2020	Publication		J Eur Acad Dermatol Venereol	Virology	Rijsbergen M, Rijneveld R, Todd M, Pagan L, Feiss G, de Koning MNC, van Alewijk DCJG, Klaassen ES, Burggraaf J, Rissmann R, van Poelgeest MIE. No effect of topical digoxin and furosemide gel for patients with external anogenital warts. J Eur Acad Dermatol Venereol. 2020 Jan;34(1):e45-e46. doi: 10.1111/jdv.15894. Epub 2019 Sep 11. PMID: 31430405.
Immunogenetics and Human Papillomavirus (HPV) in Male Genital Lichen Sclerosus (mglsc)	2020	Publication		Int J STD AIDS	Virology	Shim TN, Harwood CA, Marsh SG, Gotch FM, Quint W, de Koning MN, Francis N, Jameson C, Freeman A, Minhas S, Dinneen M, Muneer A, Bunker CB. Immunogenetics and human papillomavirus (HPV) in male genital lichen sclerosus (MGLSc). Int J STD AIDS. 2020 Dec;31(14):1334-1339. doi: 10.1177/0956462420949395. Epub 2020 Oct 21. PMID: 33081649.
Immune Response Following Quadrivalent Human Papillomavirus Vaccination in Women After Hematopoietic Allogeneic Stem Cell Transplant	2020	Publication		JAMA Oncol	Virology	Stratton P, Battiwalla M, Tian X, Abdelazim S, Baird K, Barrett AJ, Cantilena CR, Childs RW, DeJesus J, Fitzhugh C, Fowler D, Gea-Banacloche J, Gress RE, Hickstein D, Hsieh M, Ito S, Kemp TJ, Khachikyan I, Merideth MA, Pavletic SZ, Quint W, Schiffman M, Scrivani C, Shanis D, Shenoy AG, Struijk L, Tisdale JF, Wagner S, Williams KM, Yu Q, Wood LV, Pinto LA. Immune Response Following Quadrivalent Human Papillomavirus Vaccination in Women After Hematopoietic Allogeneic Stem Cell Transplant: A Nonrandomized Clinical Trial. JAMA Oncol. 2020 May 1;6(5):696-705. doi: 10.1001/jamaoncol.2019.6722. PMID: 32105293; PMCID: PMC7144415.
Efficacy of the AS04-Adjuvanted HPV16/18 Vaccine: Pooled Analysis of the Costa Rica Vaccine and PATRICIA Randomized Controlled Trials	2020	Publication		J Natl Cancer Inst	Virology	Tota JE, Struyf F, Sampson JN, Gonzalez P, Ryser M, Herrero R, Schussler J, Karkada N, Rodriguez AC, Folschweiller N, Porras C, Schiffman M, Schiller JT, Quint W, Kreimer AR, Wheeler CM, Hildesheim A; Costa Rica Vaccine Trial and PATRICIA Study. Efficacy of the AS04-Adjuvanted HPV16/18 Vaccine: Pooled Analysis of the Costa Rica Vaccine and PATRICIA Randomized Controlled Trials. J Natl Cancer Inst. 2020 Aug 1;112(8):818-828. doi: 10.1093/jnci/djz222. PMID: 31697384; PMCID: PMC7825474.
Durability of Cross-Protection by Different Schedules of the Bivalent HPV Vaccine: The CVT Trial	2020	Publication		J Natl Cancer Inst	Virology	Tsang SH, Sampson JN, Schussler J, Porras C, Wagner S, Boland J, Cortes B, Lowy DR, Schiller JT, Schiffman M, Kemp TJ, Rodriguez AC, Quint W, Gail MH, Pinto LA, Gonzalez P, Hildesheim A, Kreimer AR, Herrero R; Costa Rica HPV Vaccine Trial (CVT) Group. Durability of Cross-Protection by Different Schedules of the Bivalent HPV Vaccine: The CVT Trial. J Natl Cancer Inst. 2020 Oct 1;112(10):1030-1037. doi: 10.1093/jnci/djaa010. PMID: 32091596; PMCID: PMC7566371.
Nasal Microbiota Dominated by Moraxella Spp. Is Associated with Respiratory Health in the Elderly Population: A Case Control Study	2020	Publication		Respir Res	Infectious diseases	van den Munckhof EHA, Hafkamp HC, de Kluijver J, Kuijper EJ, de Koning MNC, Quint WGV, Knetsch CW. Nasal microbiota dominated by Moraxella spp. is associated with respiratory health in the elderly population: a case control study. Respir Res. 2020 Jul 14;21(1):181. doi: 10.1186/s12931-020-01443-8. PMID: 32664929; PMCID: PMC7362441.
Inter- and Intra-Patient Variability Over Time of Lesional Skin Microbiota in Adult Patients with Atopic Dermatitis	2020	Publication		Acta Derm Venereol	Infectious diseases	van den Munckhof EHA, Niemeyer-van der Kolk T, van der Wall H, van Alewijk DCJG, van Doorn MBA, Burggraaf J, Buters TP, Becker MJ, Feiss GL, Quint WGV, van Doorn LJ, Knetsch CW, Rissmann R. Inter- and Intra-patient Variability Over Time of Lesional Skin Microbiota in Adult Patients with Atopic Dermatitis. Acta Derm Venereol. 2020 Jan 7;100(1):adv00018. doi: 10.2340/00015555-3373. PMID: 31742645; PMCID: PMC9128996.
Identification of HPV Genotypes Causing Cervical Precancer Using Tissue-Based Genotyping	2020	Publication		Int J Cancer	Solid tumors	Venetianer R, Clarke MA, van der Marel J, Tota J, Schiffman M, Dunn ST, Walker J, Zuna R, Quint W, Wentzensen N. Identification of HPV genotypes causing cervical precancer using tissue-based genotyping. Int J Cancer. 2020 May 15;146(10):2836-2844. doi: 10.1002/ijc.32919. Epub 2020 Feb 22. PMID: 32037535.
FAM19A4/miR124-2 Methylation in Invasive Cervical Cancer: A Retrospective Cross-Sectional Worldwide Study	2020	Publication		Int J Cancer	Solid tumors	Vink FJ, Meijer CJLM, Clifford GM, Poljak M, Oštrbenk A, Petry KU, Rothe B, Bonde J, Pedersen H, de Sanjosé S, Torres M, Del Pino M, Quint WGV, Cuschieri K, Boada EA, van Trommel NE, Lissenberg-Witte BI, Floore AN, Hesselink AT, Steenbergen RDM, Bleeker MCG, Heideman DAM. FAM19A4/miR124-2 methylation in invasive cervical cancer: A retrospective cross-sectional worldwide study. Int J Cancer. 2020 Aug 15;147(4):1215-1221. doi: 10.1002/ijc.32614. Epub 2019 Sep 9. PMID: 31390052; PMCID: PMC7383900.
Molecular Epidemiology and Clinical Impact of Rhinovirus Infections in Adults During Three Epidemic Seasons in 11 European Countries (2007–2010)	2020	Publication		Thorax	Virology	Zlateva KT, van Rijn AL, Simmonds P, Coenjaerts FEJ, van Loon AM, Verheij TJM, de Vries JJC, Little P, Butler CC, van Zwet EW, Goossens H, Ieven M, Claas ECJ; GRACE Study Group. Molecular epidemiology and clinical impact of rhinovirus infections in adults during three epidemic seasons in 11 European countries (2007-2010). Thorax. 2020 Oct;75(10):882-890. doi: 10.1136/thoraxjnl-2019-214317. Epub 2020 Aug 20. PMID: 32820081; PMCID: PMC7509388.
Animal Models for COVID-19	2020	Publication		Nature	Virology	Muñoz-Fontela C, Dowling WE, Funnell SGP, Gsell PS, Riveros-Balta AX, Albrecht RA, Andersen H, Baric RS, Carroll MW, Cavaleri M, Qin C, Crozier I, Dallmeier K, de Waal L, de Wit E, Delang L, Dohm E, Duprex WP, Falzarano D, Finch CL, Frieman MB, Graham BS, Gralinski LE, Guilfoyle K, Haagmans BL, Hamilton GA, Hartman AL, Herfst S, Kaptein SJF, Klimstra WB, Knezevic I, Krause PR, Kuhn JH, Le Grand R, Lewis MG, Liu WC, Maisonnasse P, McElroy AK, Munster V, Oreshkova N, Rasmussen AL, Rocha-Pereira J, Rockx B, Rodríguez E, Rogers TF, Salguero FJ, Schotsaert M, Stittelaar KJ, Thibaut HJ, Tseng CT, Vergara-Alert J, Beer M, Brasel T, Chan JFW, García-Sastre A, Neyts J, Perlman S, Reed DS, Richt JA, Roy CJ, Segalés J, Vasan SS, Henao-Restrepo AM, Barouch DH. Animal models for COVID-19. Nature. 2020 Oct;586(7830):509-515. doi: 10.1038/s41586-020-2787-6. Epub 2020 Sep 23. PMID: 32967005; PMCID: PMC8136862.
How the COVID-19 Pandemic Highlights the Necessity of Animal Research	2020	Publication		Curr Biol	Virology	Genzel L, Adan R, Berns A, van den Beucken JJJP, Blokland A, Boddeke EHWGM, Bogers WM, Bontrop R, Bulthuis R, Bousema T, Clevers H, Coenen TCJJ, van Dam AM, Deen PMT, van Dijk KW, Eggen BJL, Elgersma Y, Erdogan I, Englitz B, Fentener van Vlissingen JM, la Fleur S, Fouchier R, Fitzsimons CP, Frieling W, Haagmans B, Heesters BA, Henckens MJAG, Herfst S, Hol E, van den Hove D, de Jonge MI, Jonkers J, Joosten LAB, Kalsbeek A, Kamermans M, Kampinga HH, Kas MJ, Keijer JA, Kersten S, Kiliaan AJ, Kooij TWA, Kooijman S, Koopman WJH, Korosi A, Krugers HJ, Kuiken T, Kushner SA, Langermans JAM, Lesscher HMB, Lucassen PJ, Lutgens E, Netea MG, Noldus LPJJ, van der Meer JWM, Meye FJ, Mul JD, van Oers K, Olivier JDA, Pasterkamp RJ, Philippens IHCHM, Prickaerts J, Pollux BJA, Rensen PCN, van Rheenen J, van Rij RP, Ritsma L, Rockx BHG, Roozendaal B, van Schothorst EM, Stittelaar K, Stockhofe N, Swaab DF, de Swart RL, Vanderschuren LJMJ, de Vries TJ, de Vrij F, van Wezel R, Wierenga CJ, Wiesmann M, Willuhn I, de Zeeuw CI, Homberg JR. How the COVID-19 pandemic highlights the necessity of animal research. Curr Biol. 2020 Sep 21;30(18):R1014-R1018. doi: 10.1016/j.cub.2020.08.030. Epub 2020 Aug 10. Erratum in: Curr Biol. 2020 Nov 2;30(21):4328. PMID: 32961149; PMCID: PMC7416712.
Comparative Pathogenesis of COVID-19, MERS, and SARS in a Nonhuman Primate Model	2020	Publication		Science	Virology	Rockx B, Kuiken T, Herfst S, Bestebroer T, Lamers MM, Oude Munnink BB, de Meulder D, van Amerongen G, van den Brand J, Okba NMA, Schipper D, van Run P, Leijten L, Sikkema R, Verschoor E, Verstrepen B, Bogers W, Langermans J, Drosten C, Fentener van Vlissingen M, Fouchier R, de Swart R, Koopmans M, Haagmans BL. Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model. Science. 2020 May 29;368(6494):1012-1015. doi: 10.1126/science.abb7314. Epub 2020 Apr 17. PMID: 32303590; PMCID: PMC7164679.
Nontraumatic Myelopathy in Malawi: A Prospective Study in an Area with High HIV Prevalence	2020	Publication		Am J Trop Med Hyg	Virology	Zijlstra EE, van Hellemond JJ, Moes AD, de Boer C, Boeschoten SA, van Blijswijk CEM, van der Vuurst de Vries RM, Bailey PAB, Kampondeni S, van Lieshout L, Smits SL, Katchanov J, Mkandawire NM, Rothe C. Nontraumatic Myelopathy in Malawi: A Prospective Study in an Area with High HIV Prevalence. Am J Trop Med Hyg. 2020 Feb;102(2):451-457. doi: 10.4269/ajtmh.19-0209. PMID: 31837130; PMCID: PMC7008330.
Particulate Multivalent Presentation of the Receptor Binding Domain Induces Protective Immune Responses Against MERS-Cov	2020	Publication		Emerg Microbes Infect	Virology	Okba NMA, Widjaja I, van Dieren B, Aebischer A, van Amerongen G, de Waal L, Stittelaar KJ, Schipper D, Martina B, van den Brand JMA, Beer M, Bosch BJ, Haagmans BL. Particulate multivalent presentation of the receptor binding domain induces protective immune responses against MERS-CoV. Emerg Microbes Infect. 2020 Dec;9(1):1080-1091. doi: 10.1080/22221751.2020.1760735. PMID: 32471334; PMCID: PMC7448924.
Prevalent Levels of RSV Serum Neutralizing Antibodies in Healthy Adults Outside the RSV-Season	2020	Publication		Hum Vaccin Immunother	Virology	Van Der Plas JL, Verdijk P, Van Brummelen EMJ, Jeeninga RE, Roestenberg M, Burggraaf J, Kamerling IMC. Prevalent levels of RSV serum neutralizing antibodies in healthy adults outside the RSV-season. Hum Vaccin Immunother. 2020 Jun 2;16(6):1322-1326. doi: 10.1080/21645515.2019.1688040. Epub 2019 Dec 20. PMID: 31674870; PMCID: PMC7482755.
Quantity Vs. Quality: An Assessment of the Current Pipeline for Rabies	2020	Publication		Trop Med Int Health	Virology	Neevel AMG, Urias E, Claassen E, van de Burgwal LHM. Quantity vs. quality: an assessment of the current pipeline for rabies. Trop Med Int Health. 2020 Apr;25(4):397-407. doi: 10.1111/tmi.13367. Epub 2020 Feb 6. PMID: 31872495.
Immunogenicity and Efficacy Comparison of MDCK Cell-Based and Egg-Based Live Attenuated Influenza Vaccines of H5 and H7 Subtypes in Ferrets	2020	Publication		Vaccine	Virology	Yeolekar LR, Guilfoyle K, Ganguly M, Tyagi P, Stittelaar KJ, van Amerongen G, Dhere RM, BerlandaScorza F, Mahmood K. Immunogenicity and efficacy comparison of MDCK cell-based and egg-based live attenuated influenza vaccines of H5 and H7 subtypes in ferrets. Vaccine. 2020 Sep 11;38(40):6280-6290. doi: 10.1016/j.vaccine.2020.07.043. Epub 2020 Jul 31. PMID: 32741671.
A Human 2D Primary Organoid-Derived Epithelial Monolayer Model to Study Host-Pathogen Interaction in the Small Intestine	2020	Publication		Front Cell Infect Microbiol	Infectious diseases	Roodsant T, Navis M, Aknouch I, Renes IB, van Elburg RM, Pajkrt D, Wolthers KC, Schultsz C, van der Ark KCH, Sridhar A, Muncan V. A Human 2D Primary Organoid-Derived Epithelial Monolayer Model to Study Host-Pathogen Interaction in the Small Intestine. Front Cell Infect Microbiol. 2020 Jun 9;10:272. doi: 10.3389/fcimb.2020.00272. PMID: 32656095; PMCID: PMC7326037.
Influenza-Induced Thrombocytopenia Is Dependent on the Subtype and Sialoglycan Receptor and Increases with Virus Pathogenicity	2020	Publication		Blood Adv	Virology	Jansen AJG, Spaan T, Low HZ, Di Iorio D, van den Brand J, Tieke M, Barendrecht A, Rohn K, van Amerongen G, Stittelaar K, Baumgärtner W, Osterhaus A, Kuiken T, Boons GJ, Huskens J, Boes M, Maas C, van der Vries E. Influenza-induced thrombocytopenia is dependent on the subtype and sialoglycan receptor and increases with virus pathogenicity. Blood Adv. 2020 Jul 14;4(13):2967-2978. doi: 10.1182/bloodadvances.2020001640. PMID: 32609845; PMCID: PMC7362372.
First-in-Human Administration of a Live-Attenuated RSV Vaccine Lacking the G-Protein Assessing Safety, Tolerability, Shedding and Immunogenicity: A Randomized Controlled Trial	2020	Publication		Vaccine	Virology	Verdijk P, van der Plas JL, van Brummelen EMJ, Jeeninga RE, de Haan CAM, Roestenberg M, Burggraaf J, Kamerling IMC. First-in-human administration of a live-attenuated RSV vaccine lacking the G-protein assessing safety, tolerability, shedding and immunogenicity: a randomized controlled trial. Vaccine. 2020 Sep 3;38(39):6088-6095. doi: 10.1016/j.vaccine.2020.07.029. Epub 2020 Jul 25. PMID: 32718816.
Dynamic Remodelling of the Human Host Cell Proteome and Phosphoproteome Upon Enterovirus Infection	2020	Publication		Nat Commun	Infectious diseases	Giansanti P, Strating JRPM, Defourny KAY, Cesonyte I, Bottino AMS, Post H, Viktorova EG, Ho VQT, Langereis MA, Belov GA, Nolte-'t Hoen ENM, Heck AJR, van Kuppeveld FJM. Dynamic remodelling of the human host cell proteome and phosphoproteome upon enterovirus infection. Nat Commun. 2020 Aug 28;11(1):4332. doi: 10.1038/s41467-020-18168-3. PMID: 32859902; PMCID: PMC7455705.
A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19	2020	Publication		The New England Journal of Medicine	Infectious diseases	B. Cao, Y. Wang, D. Wen, W. Liu, Jingli Wang, G. Fan, L. Ruan, B. Song, Y. Cai, M. Wei, X. Li, J. Xia, N. Chen, J. Xiang, T. Yu, T. Bai, X. Xie, L. Zhang, C. Li, Y. Yuan, H. Chen, Huadong Li, H. Huang, S. Tu, F. Gong, Y. Liu, Y. Wei, C. Dong, F. Zhou, X. Gu, J. Xu, Z. Liu, Y. Zhang, Hui Li, L. Shang, K. Wang, K. Li, X. Zhou, X. Dong, Z. Qu, S. Lu, X. Hu, S. Ruan, S. Luo, J. Wu, L. Peng, F. Cheng, L. Pan, J. Zou, C. Jia, Juan Wang, X. Liu, S. Wang, X. Wu, Q. Ge, J. He, H. Zhan, F. Qiu, L. Guo, C. Huang, T. Jaki, F.G. Hayden, P.W. Horby, D. Zhang, and C. Wang
Non-Invasive Novel Biomarkers to Predict Alzheimer’s Risk	2020	Publication		International Clinical Trials	Neurology	Simon Samaan, Jérôme Sallette
Clinical Validation of a Novel Automated Cell-Free DNA Screening Assay for Trisomies 21, 13, and 18 in Maternal Plasma	2019	Publication		Prenat Diagn	Rare diseases	Ericsson O, Ahola T, Dahl F, Karlsson F, Persson F, Karlberg O, Roos F, Alftrén I, Andersson B, Barkenäs E, Boghos A, Brandner B, Dahlberg J, Forsgren PO, Francois N, Gousseva A, Hakamali F, Janfalk-Carlsson Å, Johansson H, Lundgren J, Mohsenchian A, Olausson L, Olofsson S, Qureshi A, Skarpås B, Svahn P, Sävneby A, Åström E, Sahlberg A, Fianu-Jonasson A, Gautier J, Costa JM, Jacobsson B, Nicolaides K. Clinical validation of a novel automated cell-free DNA screening assay for trisomies 21, 13, and 18 in maternal plasma. Prenat Diagn. 2019 Oct;39(11):1011-1015. doi: 10.1002/pd.5528. Epub 2019 Aug 19. PMID: 31429096; PMCID: PMC6899636.
Recommendations for Classification of Commercial LBA Kits for Biomarkers in Drug Development From the GCC for Bioanalysis	2019	Publication		Bioanalysis	Cross-therapeutic area	Islam R, Kar S, Ritzén H, Hays A, Tayyem R, Barry C, Keyhani A, Zimmer J, Cruz Caturla M, Couerbe P, Warren M, Khadang A, Bourdage J, Lindley K, Williams D, Hughes N, Sheldon C, Satterwhite C, Vija J, Yu M, Boulay I, Stamatopoulos J, Lin J, Cape S, Estdale S, Thomas E, Dinan A, MacNeill R, Xiao YQ, Garofolo W, Savoie N, Brown M, Rhyne P, Hristopoulos G, Xu A, Goodwin L, Spriggs F, Xu A, Awaiye K, Hayes R, St Charles J, Bouhajib M, DiMarco C, DiMarco L, Savu SR, Bennett P, Kakkanaiah V, Nehls C, Stouffer B, Tabler E, Briscoe C, Karnik S, DuBey I, Kulagina N, Lindsay J, Beaver C, Williard C, Wang H, Feng H, Malone M, Wells E, Fang X, Moussallie M. Recommendations for classification of commercial LBA kits for biomarkers in drug development from the GCC for bioanalysis. Bioanalysis. 2019 Apr;11(7):645-653. doi: 10.4155/bio-2019-0072. Epub 2019 Apr 17. PMID: 30993999.
12th GCC Closed Forum: Critical Reagents; Oligonucleotides; Coa; Method Transfer; HRMS; Flow Cytometry; Regulatory Findings; Stability and Immunogenicity	2019	Publication		Bioanalysis	Cross-therapeutic area	Briscoe C, Hughes N, Hayes R, Islam R, Bennett P, Stouffer B, Cape S, Rhyne P, Beaver C, Charles JS, Kakkanaiah V, Xu A, Caturla MC, Spriggs F, Tayyem R, Barry C, Keyhani A, Zimmer J, Couerbe P, Warren M, Khadang A, Bourdage J, Lindley K, Williams D, Sheldon C, Satterwhite C, Vija J, Yu M, Boulay I, Stamatopoulos J, Lin J, Estdale S, Thomas E, Dinan A, MacNeill R, Xiao YQ, Matassa L, Garofolo W, Savoie N, Hristopoulos G, Xu A, Goodwin L, Awaiye K, Ritzén H, Bouhajib M, Marco CD, Savu SR, Nehls C, Tabler E, Hays A, Karnik S, Brown M, Lowes S, DuBey I, Kulagina N, Lindsay J, Williard C, Wang H, Malone M, Wells E, Fang X, Moussallie M. 12th GCC Closed Forum: critical reagents; oligonucleotides; CoA; method transfer; HRMS; flow cytometry; regulatory findings; stability and immunogenicity. Bioanalysis. 2019 Jun;11(12):1129-1138. doi: 10.4155/bio-2019-0131. Epub 2019 Jul 19. PMID: 31319683.
Introduction of Primary Screening Using High-Risk HPV DNA Detection in the Dutch Cervical Cancer Screening Programme: A Population-Based Cohort Study	2019	Publication		BMC Med	Solid tumors	Aitken CA, van Agt HME, Siebers AG, van Kemenade FJ, Niesters HGM, Melchers WJG, Vedder JEM, Schuurman R, van den Brule AJC, van der Linden HC, Hinrichs JWJ, Molijn A, Hoogduin KJ, van Hemel BM, de Kok IMCM. Introduction of primary screening using high-risk HPV DNA detection in the Dutch cervical cancer screening programme: a population-based cohort study. BMC Med. 2019 Dec 11;17(1):228. doi: 10.1186/s12916-019-1460-0. PMID: 31829241; PMCID: PMC6907114.
Burden of Human Papillomavirus (HPV)-Related Cancers Attributable to Hpvs 6/11/16/18/31/33/45/52 and 58	2019	Publication		NCI Cancer Spectr	Solid tumors	de Sanjosé S, Serrano B, Tous S, Alejo M, Lloveras B, Quirós B, Clavero O, Vidal A, Ferrándiz-Pulido C, Pavón MÁ, Holzinger D, Halec G, Tommasino M, Quint W, Pawlita M, Muñoz N, Bosch FX, Alemany L; RIS HPV TT, VVAP and Head and Neck study groups. Burden of Human Papillomavirus (HPV)-Related Cancers Attributable to HPVs 6/11/16/18/31/33/45/52 and 58. JNCI Cancer Spectr. 2019 Jan 7;2(4):pky045. doi: 10.1093/jncics/pky045. PMID: 31360870; PMCID: PMC6649711.
Evaluating the Utility and Prevalence of HPV Biomarkers in Oral Rinses and Serology for HPV-Related Oropharyngeal Cancer	2019	Publication		Cancer Prev Res (Phila)	Virology	D'Souza G, Clemens G, Troy T, Castillo RG, Struijk L, Waterboer T, Bender N, Pierorazio PM, Best SR, Strickler H, Wiley DJ, Haddad RI, Posner M, Fakhry C. Evaluating the Utility and Prevalence of HPV Biomarkers in Oral Rinses and Serology for HPV-related Oropharyngeal Cancer. Cancer Prev Res (Phila). 2019 Oct;12(10):689-700. doi: 10.1158/1940-6207.CAPR-19-0185. Epub 2019 Aug 16. PMID: 31420362; PMCID: PMC7029397.
Intra- and Inter-Laboratory Agreement of the FAM19A4/mir124-2 Methylation Test: Results From an International Study	2019	Publication		J Clin Lab Anal	Cross-therapeutic area	Floore A, Hesselink A, Oštrbenk A, Alcaniz E, Rothe B, Pedersen H, Torres Hortal M, Doorn S, Quint W, Petry KU, Poljak M, Cuschieri K, Bonde J, de Sanjosé S, Bleeker M, Heideman D. Intra- and inter-laboratory agreement of the FAM19A4/mir124-2 methylation test: Results from an international study. J Clin Lab Anal. 2019 May;33(4):e22854. doi: 10.1002/jcla.22854. Epub 2019 Feb 13. PMID: 30758084; PMCID: PMC6528594.
Human Papillomavirus Type 16 Causes a Defined Subset of Conjunctival in Situ Squamous Cell Carcinomas	2019	Publication		Mod Pathol	Solid tumors	Griffin H, Mudhar HS, Rundle P, Shiraz A, Mahmood R, Egawa N, Quint W, Rennie IG, Doorbar J. Human papillomavirus type 16 causes a defined subset of conjunctival in situ squamous cell carcinomas. Mod Pathol. 2020 Jan;33(1):74-90. doi: 10.1038/s41379-019-0350-5. Epub 2019 Sep 4. Erratum in: Mod Pathol. 2019 Oct 15;: PMID: 31485010; PMCID: PMC6930848.
Whole Tissue Cervical Mapping of HPV Infection: Molecular Evidence for Focal Latent HPV Infection in Humans	2019	Publication		Papillomavirus Res	Virology	Hammer A, de Koning MN, Blaakaer J, Steiniche T, Doorbar J, Griffin H, Mejlgaard E, Svanholm H, Quint WG, Gravitt PE. Whole tissue cervical mapping of HPV infection: Molecular evidence for focal latent HPV infection in humans. . 2019 Jun;7:82-87. doi: 10.1016/j.pvr.2019.02.004. Epub 2019 Feb 14. PMID: 30772498; PMCID: PMC6389775.
Clinical Performance of the HPV-Risk Assay on Cervical Samples in Surepath Medium Using the VALGENT-4 Panel	2019	Publication		J Clin Virol	Virology	Heideman DAM, Xu L, Hesselink AT, Doorn S, Ejegod DM, Pedersen H, Quint WGV, Bonde J, Arbyn M. Clinical performance of the HPV-Risk assay on cervical samples in SurePath medium using the VALGENT-4 panel. J Clin Virol. 2019 Dec;121:104201. doi: 10.1016/j.jcv.2019.104201. Epub 2019 Oct 12. PMID: 31629967.
Utility of Stathmin-1 as a Novel Marker in Evaluating Anal Intraepithelial Neoplasia (AIN)	2019	Publication		Mol Morphol	Solid tumors	Hissong E, Cimic A, Leeman A, Pirog EC. Utility of Stathmin-1 as a Novel Marker in Evaluating Anal Intraepithelial Neoplasia (AIN). Appl Immunohistochem Mol Morphol. 2019 Feb;27(2):134-139. doi: 10.1097/PAI.0000000000000547. PMID: 28777150.
Reliable Identification of Women with CIN3+ Using Hrhpv Genotyping and Methylation Markers in a Cytology-Screened Referral Population	2019	Publication		Int J Cancer	Virology	Leeman A, Del Pino M, Marimon L, Torné A, Ordi J, Ter Harmsel B, Meijer CJLM, Jenkins D, Van Kemenade FJ, Quint WGV. Reliable identification of women with CIN3+ using hrHPV genotyping and methylation markers in a cytology-screened referral population. Int J Cancer. 2019 Jan 1;144(1):160-168. doi: 10.1002/ijc.31787. Epub 2018 Nov 18. PMID: 30098013; PMCID: PMC6587551.
Estimating the Human Papillomavirus Genotype Attribution in Screen-Detected High-Grade Cervical Lesions	2019	Publication		Epidemiology	Solid tumors	Lissenberg-Witte BI, Bogaards JA, Quint WGV, Berkhof J. Estimating the Human Papillomavirus Genotype Attribution in Screen-detected High-grade Cervical Lesions. Epidemiology. 2019 Jul;30(4):590-596. doi: 10.1097/EDE.0000000000001026. Erratum in: Epidemiology. 2020 Jan;31(1):e9-e10. PMID: 30985528.
Virological and Serological Predictors of Anal High-Grade Squamous Intraepithelial Lesions Among Human Immunodeficiency Virus–Positive Men Who Have Sex with Men	2019	Publication		Clin Infect Dis	Solid tumors	Marra E, Siegenbeek van Heukelom ML, Leeman A, Waterboer T, Meijer CJLM, Snijders PJF, King AJ, Cairo I, van Eeden A, Brokking W, van der Weele P, Quint W, Prins JM, de Vries HJC, Schim van der Loeff MF. Virological and Serological Predictors of Anal High-grade Squamous Intraepithelial Lesions Among Human Immunodeficiency Virus-positive Men Who Have Sex With Men. Clin Infect Dis. 2019 Apr 8;68(8):1377-1387. doi: 10.1093/cid/ciy719. PMID: 30165551.
Human Papillomavirus (HPV) Vaccine Effectiveness and Potential Herd Immunity for Reducing Oncogenic Oropharyngeal HPV-16 Prevalence in the United Kingdom: A Cross-Sectional Study	2019	Publication		Clin Infect Dis	Solid tumors	Mehanna H, Bryant TS, Babrah J, Louie K, Bryant JL, Spruce RJ, Batis N, Olaleye O, Jones J, Struijk L, Molijn A, Vorsters A, Rosillon D, Taylor S, D'Souza G. Human Papillomavirus (HPV) Vaccine Effectiveness and Potential Herd Immunity for Reducing Oncogenic Oropharyngeal HPV-16 Prevalence in the United Kingdom: A Cross-sectional Study. Clin Infect Dis. 2019 Sep 27;69(8):1296-1302. doi: 10.1093/cid/ciy1081. PMID: 30590469; PMCID: PMC6763631.
Impact of Host DNA and Sequencing Depth on the Taxonomic Resolution of Whole Metagenome Sequencing for Microbiome Analysis	2019	Publication		Front Microbiol	Infectious diseases	Pereira-Marques J, Hout A, Ferreira RM, Weber M, Pinto-Ribeiro I, van Doorn LJ, Knetsch CW, Figueiredo C. Impact of Host DNA and Sequencing Depth on the Taxonomic Resolution of Whole Metagenome Sequencing for Microbiome Analysis. Front Microbiol. 2019 Jun 12;10:1277. doi: 10.3389/fmicb.2019.01277. PMID: 31244801; PMCID: PMC6581681.
Distinct Geographic Clustering of Oncogenic Human Papillomaviruses Multiple Infections in Cervical Cancers: Results From a Worldwide Cross-Sectional Study	2019	Publication		Int J Cancer	Solid tumors	Pimenoff VN, Tous S, Benavente Y, Alemany L, Quint W, Bosch FX, Bravo IG, de Sanjosé S. Distinct geographic clustering of oncogenic human papillomaviruses multiple infections in cervical cancers: Results from a worldwide cross-sectional study. Int J Cancer. 2019 May 15;144(10):2478-2488. doi: 10.1002/ijc.31964. Epub 2018 Dec 11. PMID: 30387873.
Gastric-Type Adenocarcinoma of the Cervix: Tumor with Wide Range of Histologic Appearances	2019	Publication		Adv Anat Pathol	Solid tumors	Pirog EC, Park KJ, Kiyokawa T, Zhang X, Chen W, Jenkins D, Quint W. Gastric- type Adenocarcinoma of the Cervix: Tumor With Wide Range of Histologic Appearances. Adv Anat Pathol. 2019 Jan;26(1):1-12. doi: 10.1097/PAP.0000000000000216. PMID: 30234500
Performance of Human Papillomavirus Testing on Self-Collected Versus Clinician-Collected Samples for the Detection of Cervical Intraepithelial Neoplasia of Grade 2 or Worse: A Randomised, Paired Screen-Positive, Non-Inferiority Trial	2019	Publication		Lancet Oncol	Solid tumors	Polman NJ, Ebisch RMF, Heideman DAM, Melchers WJG, Bekkers RLM, Molijn AC, Meijer CJLM, Quint WGV, Snijders PJF, Massuger LFAG, van Kemenade FJ, Berkhof J. Performance of human papillomavirus testing on self-collected versus clinician-collected samples for the detection of cervical intraepithelial neoplasia of grade 2 or worse: a randomised, paired screen-positive, non-inferiority trial. Lancet Oncol. 2019 Feb;20(2):229-238. doi: 10.1016/S1470-2045(18)30763-0. Epub 2019 Jan 15. PMID: 30658933.
A Randomized Controlled Proof‐of‐concept Trial of Digoxin and Furosemide in Adults with Cutaneous Warts	2019	Publication		Br J Dermatol	Virology	Rijsbergen M, Niemeyer-van der Kolk T, Hogendoorn G, Kouwenhoven S, Lemoine C, Klaassen ES, de Koning M, Beck S, Bouwes Bavinck JN, Feiss G, Burggraaf J, Rissmann R. A randomized controlled proof-of-concept trial of digoxin and furosemide in adults with cutaneous warts. Br J Dermatol. 2019 May;180(5):1058-1068. doi: 10.1111/bjd.17583. Epub 2019 Mar 7. PMID: 30580460; PMCID: PMC6850412.
Evaluation of a Stepwise Approach Using Microbiota Analysis, Species-Specific Qpcrs and Culture for the Diagnosis of Lower Respiratory Tract Infections	2019	Publication		Eur J Clin Microbiol Infect Dis	Infectious diseases	van den Munckhof EHA, de Koning MNC, Quint WGV, van Doorn LJ, Leverstein-van Hall MA. Evaluation of a stepwise approach using microbiota analysis, species-specific qPCRs and culture for the diagnosis of lower respiratory tract infections. Eur J Clin Microbiol Infect Dis. 2019 Apr;38(4):747-754. doi: 10.1007/s10096-019-03511-4. Epub 2019 Feb 20. PMID: 30788730.
Comparison of Amsel Criteria, Nugent Score, Culture and Two CE-IVD Marked Quantitative Real-Time Pcrs with Microbiota Analysis for the Diagnosis of Bacterial Vaginosis	2019	Publication		Eur J Clin Microbiol Infect Dis	Infectious diseases	van den Munckhof EHA, van Sitter RL, Boers KE, Lamont RF, Te Witt R, le Cessie S, Knetsch CW, van Doorn LJ, Quint WGV, Molijn A, Leverstein-van Hall MA. Comparison of Amsel criteria, Nugent score, culture and two CE-IVD marked quantitative real-time PCRs with microbiota analysis for the diagnosis of bacterial vaginosis. Eur J Clin Microbiol Infect Dis. 2019 May;38(5):959-966. doi: 10.1007/s10096-019-03538-7. Epub 2019 Mar 22. PMID: 30903536.
Host Cell Deoxyribonucleic Acid Methylation Markers for the Detection of High-Grade Anal Intraepithelial Neoplasia and Anal Cancer	2019	Publication		Clin Infect Dis	Solid tumors	van der Zee RP, Richel O, van Noesel CJM, Novianti PW, Ciocanea-Teodorescu I, van Splunter AP, Duin S, van den Berk GEL, Meijer CJLM, Quint WGV, de Vries HJC, Prins JM, Steenbergen RDM. Host Cell Deoxyribonucleic Acid Methylation Markers for the Detection of High-grade Anal Intraepithelial Neoplasia and Anal Cancer. Clin Infect Dis. 2019 Mar 19;68(7):1110-1117. doi: 10.1093/cid/ciy601. PMID: 30060049; PMCID: PMC6424081.
Evaluation of Typeseq, a Novel High-Throughput, Low-Cost, Next-Generation Sequencing-Based Assay for Detection of 51 Human Papillomavirus Genotypes	2019	Publication		J Infect Dis	Virology	Wagner S, Roberson D, Boland J, Kreimer AR, Yeager M, Cullen M, Mirabello L, Dunn ST, Walker J, Zuna R, Porras C, Cortes B, Sampson J, Herrero R, Rodriguez AC, Quint W, Van Doorn LJ; CVT Group; Hildesheim A, Schiffman M, Wentzensen N. Evaluation of TypeSeq, a Novel High-Throughput, Low-Cost, Next-Generation Sequencing-Based Assay for Detection of 51 Human Papillomavirus Genotypes. J Infect Dis. 2019 Oct 8;220(10):1609-1619. doi: 10.1093/infdis/jiz324. PMID: 31536132; PMCID: PMC6782103.
Hypoxia-Induced Human Deoxyribonuclease I Is a Cellular Restriction Factor of Hepatitis B Virus	2019	Publication		Nat Microbiol	Virology	Hallez C, Li X, Suspène R, Thiers V, Bouzidi MS, M Dorobantu C, Lucansky V, Wain-Hobson S, Gaudin R, Vartanian JP. Hypoxia-induced human deoxyribonuclease I is a cellular restriction factor of hepatitis B virus. Nat Microbiol. 2019 Jul;4(7):1196-1207. doi: 10.1038/s41564-019-0405-x. Epub 2019 Apr 1. PMID: 30936483.
Safety and Efficacy of Monoclonal Antibody VIS410 in Adults with Uncomplicated Influenza A Infection: Results From a Randomized, Double-Blind, Phase-2, Placebo-Controlled Study	2019	Publication		EBioMedicine	Virology	Hershberger E, Sloan S, Narayan K, Hay CA, Smith P, Engler F, Jeeninga R, Smits S, Trevejo J, Shriver Z, Oldach D. Safety and efficacy of monoclonal antibody VIS410 in adults with uncomplicated influenza A infection: Results from a randomized, double-blind, phase-2, placebo-controlled study. EBioMedicine. 2019 Feb;40:574-582. doi: 10.1016/j.ebiom.2018.12.051. Epub 2019 Jan 9. PMID: 30638863; PMCID: PMC6412085.
Lack of Middle East Respiratory Syndrome Coronavirus Transmission in Rabbits	2019	Publication		Viruses	Virology	Widagdo W, Okba NMA, Richard M, de Meulder D, Bestebroer TM, Lexmond P, Farag EABA, Al-Hajri M, Stittelaar KJ, de Waal L, van Amerongen G, van den Brand JMA, Haagmans BL, Herfst S. Lack of Middle East Respiratory Syndrome Coronavirus Transmission in Rabbits. Viruses. 2019 Apr 24;11(4):381. doi: 10.3390/v11040381. PMID: 31022948; PMCID: PMC6520746.
Clinical Validation of a Novel Automated Cell‐free DNA Screening Assay for Trisomies 21, 13, and 18 in Maternal Plasma	2019	Publication		Prenatal Diagnosis	Cross-therapeutic area	Olle Ericsson, Tarja Ahola, Fredrik Dahl, Filip Karlsson, Fredrik Persson, Olof Karlberg, Fredrik Roos, Ida Alftrén, Björn Andersson, Emelie Barkenäs, Ani Boghos, Birgit Brandner, Jenny Dahlberg, Per‐Ola Forsgren, Niels Francois, Anna Gousseva, Faizan Hakamali, Åsa Janfalk‐Carlsson, Henrik Johansson, Johanna Lundgren, Atefeh Mohsenchian, Linus Olausson, Simon Olofsson, Atif Qureshi, Björn Skarpås, Peter Svahn, Anna Sävneby, Eva Åström, Anna Sahlberg, Aino Fianu‐Jonasson, Jérémie Gautier, Jean‐Marc Costa, Bo Jacobsson, Kypros Nicolaides
Establishment of Reference Intervals for the Salivary Cortisol Circadian Cycle, by Electrochemiluminescence (ECLIA), in Healthy Adults	2018	Publication		Bioanalysis	Cross-therapeutic area	Gagnon N, Fréchette I, Mallet PL, Dubé J, Houde G, Fink GD. Establishment of reference intervals for the salivary cortisol circadian cycle, by electrochemiluminescence (ECLIA), in healthy adults. Clin Biochem. 2018 Apr;54:56-60. doi: 10.1016/j.clinbiochem.2018.02.012. Epub 2018 Feb 19. PMID: 29470960.
11th GCC Closed Forum: Cumulative Stability; Matrix Stability; Immunogenicity Assays; Laboratory Manuals; Biosimilars; Chiral Methods; Hybrid LBA/LCMS Assays; Fit-for-Purpose Validation; China Food and Drug Administration Bioanalytical Method Validation	2018	Publication		Bioanalysis	Cross-therapeutic area	Islam R, Briscoe C, Bower J, Cape S, Arnold M, Hayes R, Warren M, Karnik S, Stouffer B, Xiao YQ, van der Strate B, Sikkema D, Fang X, Tudoroniu A, Tayyem R, Brant A, Spriggs F, Barry C, Khan M, Keyhani A, Zimmer J, Caturla MC, Couerbe P, Khadang A, Bourdage J, Datin J, Zemo J, Hughes N, Fatmi S, Sheldon C, Fountain S, Satterwhite C, Colletti K, Vija J, Yu M, Stamatopoulos J, Lin J, Wilfahrt J, Dinan A, Ohorodnik S, Hulse J, Patel V, Garofolo W, Savoie N, Brown M, Papac D, Buonarati M, Hristopoulos G, Beaver C, Boudreau N, Williard C, Liu Y, Ray G, Warrino D, Xu A, Green R, Hayward-Sewell J, Marcelletti J, Sanchez C, Kennedy M, Charles JS, Bouhajib M, Nehls C, Tabler E, Tu J, Joyce P, Iordachescu A, DuBey I, Lindsay J, Yamashita J, Wells E. 11th GCC Closed Forum: cumulative stability; matrix stability; immunogenicity assays; laboratory manuals; biosimilars; chiral methods; hybrid LBA/LCMS assays; fit-for-purpose validation; China Food and Drug Administration bioanalytical method validation. Bioanalysis. 2018 Apr 1;10(7):433-444. doi: 10.4155/bio-2018-0014. Epub 2018 Apr 27. PMID: 29701066.
Contribution of Human Papillomavirus in Neuroendocrine Tumors From a Series of 10,575 Invasive Cervical Cancer Cases	2018	Publication		Papillomavirus Res	Solid tumors	Alejo M, Alemany L, Clavero O, Quiros B, Vighi S, Seoud M, Cheng-Yang C, Garland SM, Juanpere N, Lloreta J, Tous S, Klaustermeier JE, Quint W, Bosch FX, de Sanjosé S, Lloveras B; RIS HPV TT study group. Contribution of Human papillomavirus in neuroendocrine tumors from a series of 10,575 invasive cervical cancer cases. Papillomavirus Res. 2018 Jun;5:134-142. doi: 10.1016/j.pvr.2018.03.005. Epub 2018 Mar 17. PMID: 29555602; PMCID: PMC5909066.
Enabling Precision Medicine via Standard Communication of HTS Provenance, Analysis, and Results	2018	Publication		PLoS Biol	Infectious diseases	Alterovitz G, Dean D, Goble C, Crusoe MR, Soiland-Reyes S, Bell A, Hayes A, Suresh A, Purkayastha A, King CH, Taylor D, Johanson E, Thompson EE, Donaldson E, Morizono H, Tsang H, Vora JK, Goecks J, Yao J, Almeida JS, Keeney J, Addepalli K, Krampis K, Smith KM, Guo L, Walderhaug M, Schito M, Ezewudo M, Guimera N, Walsh P, Kahsay R, Gottipati S, Rodwell TC, Bloom T, Lai Y, Simonyan V, Mazumder R. Enabling precision medicine via standard communication of HTS provenance, analysis, and results. PLoS Biol. 2018 Dec 31;16(12):e3000099. doi: 10.1371/journal.pbio.3000099. PMID: 30596645; PMCID: PMC6338479.
The Valgent4 Protocol: Robust Analytical and Clinical Validation of 11 HPV Assays with Genotyping on Cervical Samples Collected in Surepath Medium	2018	Publication		J Clin Virol	Virology	Bonde J, Ejegod DM, Cuschieri K, Dillner J, Heideman DAM, Quint W, Pavon Ribas MA, Padalko E, Christiansen IK, Xu L, Arbyn M. The Valgent4 protocol: Robust analytical and clinical validation of 11 HPV assays with genotyping on cervical samples collected in SurePath medium. J Clin Virol. 2018 Nov;108:64-71. doi: 10.1016/j.jcv.2018.09.012. Epub 2018 Sep 17. PMID: 30253376.
Human Papillomavirus and Posttransplantation Cutaneous Squamous Cell Carcinoma: A Multicenter, Prospective Cohort Study	2018	Publication		Am J Transplant	Solid tumors	Bouwes Bavinck JN, Feltkamp MCW, Green AC, Fiocco M, Euvrard S, Harwood CA, Nasir S, Thomson J, Proby CM, Naldi L, Diphoorn JCD, Venturuzzo A, Tessari G, Nindl I, Sampogna F, Abeni D, Neale RE, Goeman JJ, Quint KD, Halk AB, Sneek C, Genders RE, de Koning MNC, Quint WGV, Wieland U, Weissenborn S, Waterboer T, Pawlita M, Pfister H; EPI-HPV-UV-CA group. Human papillomavirus and posttransplantation cutaneous squamous cell carcinoma: A multicenter, prospective cohort study. Am J Transplant. 2018 May;18(5):1220-1230. doi: 10.1111/ajt.14537. Epub 2017 Nov 22. PMID: 29024374; PMCID: PMC5947129.
The Variable Characteristics of Human Papillomavirus in Squamous Cell Carcinoma and Adenocarcinoma of Cervix in China	2018	Publication		J Low Genit Tract Dis	Solid tumors	Chen W, Sun H, Molijn A, Zeng L, Kang L, Jenkins D, Zhang S, Cui J, Wu Z, Pirog E, Shen G, Zhang X, Qiao Y; Chinese HPV Typing Group. The Variable Characteristics of Human Papillomavirus in Squamous Cell Carcinoma and Adenocarcinoma of Cervix in China. J Low Genit Tract Dis. 2018 Oct;22(4):355-361. doi: 10.1097/LGT.0000000000000408. PMID: 30074955.
Vulvar Cancer: Two Pathways with Different Localization and Prognosis	2018	Publication		Gynecol Oncol	Solid tumors	Hinten F, Molijn A, Eckhardt L, Massuger LFAG, Quint W, Bult P, Bulten J, Melchers WJG, de Hullu JA. Vulvar cancer: Two pathways with different localization and prognosis. Gynecol Oncol. 2018 May;149(2):310-317. doi: 10.1016/j.ygyno.2018.03.003. Epub 2018 Mar 16. PMID: 29555332.
Morphological Characteristics and Human Papillomavirus Genotype Predict the Treatment Response in Cutaneous Warts	2018	Publication		Br J Dermatol	Virology	Hogendoorn GK, Bruggink SC, de Koning MNC, Eekhof JAH, Hermans KE, Rissmann R, Burggraaf J, Wolterbeek R, Quint KD, Kouwenhoven STP, Bouwes Bavinck JN. Morphological characteristics and human papillomavirus genotype predict the treatment response in cutaneous warts. Br J Dermatol. 2018 Jan;178(1):253-260. doi: 10.1111/bjd.15758. Epub 2017 Dec 14. PMID: 28646591.
High Prevalence of High-Risk HPV Genotypes Other Than 16 and 18 in Cervical Cancers of Curaçao: Implications for Choice of Prophylactic HPV Vaccine	2018	Publication		Br J Dermatol	Virology	Hogendoorn GK, Bruggink SC, Hermans KE, Kouwenhoven STP, Quint KD, Wolterbeek R, Eekhof JAH, de Koning MNC, Rissmann R, Burggraaf J, Bouwes Bavinck JN. Developing and validating the Cutaneous WARTS (CWARTS) diagnostic tool: a novel clinical assessment and classification system for cutaneous warts. Br J Dermatol. 2018 Feb;178(2):527-534. doi: 10.1111/bjd.15999. Epub 2017 Dec 18. PMID: 28949011.
High Prevalence of High-Risk HPV Genotypes Other Than 16 and 18 in Cervical Cancers of Curaçao: Implications for Choice of Prophylactic HPV Vaccine	2018	Publication		Sex Transm Infect	Solid tumors	Hooi DJ, Lissenberg-Witte BI, de Koning MNC, Pinedo HM, Kenter GG, Meijer CJ, Quint WG. High prevalence of high-risk HPV genotypes other than 16 and 18 in cervical cancers of Curaçao: implications for choice of prophylactic HPV vaccine. Sex Transm Infect. 2018 Jun;94(4):263-267. doi: 10.1136/sextrans-2017-053109. Epub 2017 Oct 11. PMID: 29021405; PMCID: PMC5969325.
Human Papillomavirus (HPV) Prevalence and Associated Risk Factors in Women From Curaçao	2018	Publication		PLoS One	Virology	Hooi DJ, Lissenberg-Witte BI, Kenter G, de Koning MNC, Gomes Bravio I, Ardts K, Kleinmoedig S, Benita E, Pinedo HM, Berkhof J, Quint WGV, Meijer CJLM. Human papillomavirus (HPV) prevalence and associated risk factors in women from Curaçao. PLoS One. 2018 Jul 13;13(7):e0199624. doi: 10.1371/journal.pone.0199624. PMID: 30005066; PMCID: PMC6044524.
Human Papillomavirus (HPV) Types Prevalence in Cervical Samples of Female Sex-Workers on Curaçao	2018	Publication		Prev Med Rep	Virology	Hooi DJ, Quint WGV, Lissenberg-Witte BI, Kenter G, Pinedo HM, de Koning MNC, Meijer CJLM. Human papillomavirus (HPV) types prevalence in cervical samples of female sex-workers on Curaçao. Prev Med Rep. 2018 Jun 2;11:120-124. doi: 10.1016/j.pmedr.2018.06.001. PMID: 29992082; PMCID: PMC6038104.
Defining Hrhpv Genotypes in Cervical Intraepithelial Neoplasia by Laser Capture Microdissection Supports Reflex Triage of Self-Samples Using HPV16/18 and FAM19A4/miR124-2 Methylation	2018	Publication		Gynecol Oncol	Solid tumors	Leeman A, Ebisch RMF, Kasius A, Bosgraaf RP, Jenkins D, van de Sandt MM, de Strooper LMA, Heideman DAM, Snijders PJF, Massuger LFAG, Bekkers RLM, Meijer CJLM, van Kemenade FJ, Quint WGV, Melchers WJG. Defining hrHPV genotypes in cervical intraepithelial neoplasia by laser capture microdissection supports reflex triage of self-samples using HPV16/18 and FAM19A4/miR124-2 methylation. Gynecol Oncol. 2018 Nov;151(2):311-318. doi: 10.1016/j.ygyno.2018.09.006. Epub 2018 Sep 13. PMID: 30219239.
Presence or Absence of Significant HPVE4 Expression in High-Grade Anal Intraepithelial Neoplasia with p16/Ki-67 Positivity Indicates Distinct Patterns of Neoplasia	2018	Publication		Am J Surg Pathol	Solid tumors	Leeman A, Pirog EC, Doorbar J, van de Sandt MM, van Kemenade FJ, Jenkins D, Quint WGV. Presence or Absence of Significant HPVE4 Expression in High-grade Anal Intraepithelial Neoplasia With p16/Ki-67 Positivity Indicates Distinct Patterns of Neoplasia: A Study Combining Immunohistochemistry and Laser Capture Microdissection PCR. Am J Surg Pathol. 2018 Apr;42(4):463-471. doi: 10.1097/PAS.0000000000000984. PMID: 29438174.
Differentiated Vulvar Intraepithelial Neoplasia-Like and Lichen Sclerosus-Like Lesions in HPV-Associated Squamous Cell Carcinomas of the Vulva	2018	Publication		Am J Surg Pathol	Solid tumors	Rakislova N, Alemany L, Clavero O, Del Pino M, Saco A, Quirós B, Lloveras B, Alejo M, Halec G, Quint W, de Sanjosé S, Ordi J; VVAP study group. Differentiated Vulvar Intraepithelial Neoplasia-like and Lichen Sclerosus-like Lesions in HPV-associated Squamous Cell Carcinomas of the Vulva. Am J Surg Pathol. 2018 Jun;42(6):828-835. doi: 10.1097/PAS.0000000000001047. PMID: 29505429.
Hepatic and Hippocampal Cytochrome P450 Enzyme Overexpression During Spontaneous Recurrent Seizures	2018	Publication		Epilepsia	Neurology	Runtz L, Girard B, Toussenot M, Espallergues J, Fayd'Herbe De Maudave A, Milman A, deBock F, Ghosh C, Guérineau NC, Pascussi JM, Bertaso F, Marchi N. Hepatic and hippocampal cytochrome P450 enzyme overexpression during spontaneous recurrent seizures. Epilepsia. 2018 Jan;59(1):123-134. doi: 10.1111/epi.13942. Epub 2017 Nov 10. PMID: 29125184; PMCID: PMC5774654.
Durability of Protection Afforded by Fewer Doses of the HPV16/18 Vaccine: The CVT Trial	2018	Publication		J Natl Cancer Inst	Virology	Safaeian M, Sampson JN, Pan Y, Porras C, Kemp TJ, Herrero R, Quint W, van Doorn LJ, Schussler J, Lowy DR, Schiller J, Schiffman MT, Rodriguez AC, Gail MH, Hildesheim A, Gonzalez P, Pinto LA, Kreimer AR; Costa Rica HPV Vaccine Trial (CVT) Group. Durability of Protection Afforded by Fewer Doses of the HPV16/18 Vaccine: The CVT Trial. J Natl Cancer Inst. 2018 Feb 1;110(2):205–12. doi: 10.1093/jnci/djx158. PMID: 28954299; PMCID: PMC6075614.
Three-Tiered Score for Ki-67 and p16 Improves Accuracy and Reproducibility of Grading CIN Lesions	2018	Publication		J Clin Pathol	Solid tumors	van Zummeren M, Leeman A, Kremer WW, Bleeker MCG, Jenkins D, van de Sandt M, Heideman DAM, Steenbergen R, Snijders PJF, Quint WGV, Berkhof J, Meijer CJLM. Three-tiered score for Ki-67 and p16ink4a improves accuracy and reproducibility of grading CIN lesions. J Clin Pathol. 2018 Nov;71(11):981-988. doi: 10.1136/jclinpath-2018-205271. Epub 2018 Jul 16. PMID: 30012698; PMCID: PMC6225805.
High Rate of Infection by Only Oncogenic Human Papillomavirus in Amerindians	2018	Publication		mSphere	Virology	Vargas-Robles D, Magris M, Morales N, de Koning MNC, Rodríguez I, Nieves T, Godoy-Vitorino F, Sánchez GI, Alcaraz LD, Forney LJ, Pérez ME, García-Briceño L, van Doorn LJ, Domínguez-Bello MG. High Rate of Infection by Only Oncogenic Human Papillomavirus in Amerindians. mSphere. 2018 May 2;3(3):e00176-18. doi: 10.1128/mSphere.00176-18. PMID: 29720524; PMCID: PMC5932372.
HPV E4 Expression and DNA Hypermethylation of CADM1, MAL, and miR124-2 Genes in Cervical Cancer and Precursor Lesions	2018	Publication		Mod Pathol	Solid tumors	Zummeren MV, Kremer WW, Leeman A, Bleeker MCG, Jenkins D, Sandt MV, Doorbar J, Heideman DAM, Steenbergen RDM, Snijders PJF, Kenter GG, Quint WGV, Berkhof J, Meijer CJLM. HPV E4 expression and DNA hypermethylation of CADM1, MAL, and miR124-2 genes in cervical cancer and precursor lesions. Mod Pathol. 2018 Dec;31(12):1842-1850. doi: 10.1038/s41379-018-0101-z. Epub 2018 Aug 22. PMID: 30135508.
A Research Agenda to Reinforce Rabies Control: A Qualitative and Quantitative Prioritization	2018	Publication		PLoS Negl Trop Dis	Virology	Neevel AMG, Hemrika T, Claassen E, van de Burgwal LHM. A research agenda to reinforce rabies control: A qualitative and quantitative prioritization. PLoS Negl Trop Dis. 2018 May 4;12(5):e0006387. doi: 10.1371/journal.pntd.0006387. PMID: 29727444; PMCID: PMC5955568.
Transmission of Human Respiratory Syncytial Virus in the Immunocompromised Ferret Model	2018	Publication		Viruses	Virology	de Waal L, Smits SL, Veldhuis Kroeze EJB, van Amerongen G, Pohl MO, Osterhaus ADME, Stittelaar KJ. Transmission of Human Respiratory Syncytial Virus in the Immunocompromised Ferret Model. Viruses. 2018 Jan 2;10(1):18. doi: 10.3390/v10010018. PMID: 29301313; PMCID: PMC5795431.
Influenza A/H3N2 Virus Infection in Immunocompromised Ferrets and Emergence of Antiviral Resistance	2018	Publication		PLoS One	Virology	Roosenhoff R, van der Vries E, van der Linden A, van Amerongen G, Stittelaar KJ, Smits SL, Schutten M, Fouchier RAM. Influenza A/H3N2 virus infection in immunocompromised ferrets and emergence of antiviral resistance. PLoS One. 2018 Jul 19;13(7):e0200849. doi: 10.1371/journal.pone.0200849. PMID: 30024940; PMCID: PMC6053203.
Immunogenicity and Efficacy of the Monovalent, Trivalent and Quadrivalent Intranasal Live Attenuated Influenza Vaccines Containing Different pdmH1N1 Strains	2018	Publication		Vaccine	Virology	Yeolekar LR, Ganguly M, Tyagi P, Ingle NB, Stittelaar KJ, Waal L, Scorza FB, Mahmood K, Dhere RM. Immunogenicity and efficacy of the monovalent, trivalent and quadrivalent intranasal live attenuated influenza vaccines containing different pdmH1N1 strains. Vaccine. 2018 Nov 12;36(46):6944-6952. doi: 10.1016/j.vaccine.2018.10.002. Epub 2018 Oct 12. PMID: 30322745.
Variation at Extra-Epitopic Amino Acid Residues Influences Suppression of Influenza Virus Replication by M158-66 Epitope-Specific CD8+ T Lymphocytes	2018	Publication		J Virol	Virology	van de Sandt CE, Pronk MR, van Baalen CA, Fouchier RAM, Rimmelzwaan GF. Variation at Extra-epitopic Amino Acid Residues Influences Suppression of Influenza Virus Replication by M158-66 Epitope-Specific CD8+ T Lymphocytes. J Virol. 2018 May 14;92(11):e00232-18. doi: 10.1128/JVI.00232-18. PMID: 29593036; PMCID: PMC5952141.
Analysis of Mouse Brain Transcriptome After Experimental Duvenhage Virus Infection Shows Activation of Innate Immune Response and Pyroptotic Cell Death Pathway	2018	Publication		Front Microbiol	Virology	Koraka P, Martina BEE, van den Ham HJ, Zaaraoui-Boutahar F, van IJcken W, Roose J, van Amerongen G, Andeweg A, Osterhaus ADME. Analysis of Mouse Brain Transcriptome After Experimental Duvenhage Virus Infection Shows Activation of Innate Immune Response and Pyroptotic Cell Death Pathway. Front Microbiol. 2018 Mar 20;9:397. doi: 10.3389/fmicb.2018.00397. PMID: 29615985; PMCID: PMC5869263.
Ultra-Deep Sequencing Reveals High Prevalence and Broad Structural Diversity of Hepatitis B Surface Antigen Mutations in a Global Population	2017	Publication		PLOS	Virology	Mikael Gencay, Kirsten Hübner, Peter Gohl, Anja Seffner, Michael Weizenegger, Dionysios Neofytos, Richard Batrla, Andreas Woeste, Hyon-suk Kim, Gaston Westergaard, Christine Reinsch, Eva Brill, Pham Thi Thu Thuy, Bui Huu Hoang, Mark Sonderup, C. Wendy Spearman, Stephan Pabinger, Jérémie Gautier, Giuseppina Brancaccio, Massimo Fasano, Teresa Santantonio, Giovanni B. Gaeta, Markus Nauck, Wolfgang E. Kaminski
Detection of in Vivo Hepatitis B Virus Surface Antigen Mutations—A Comparison of Four Routine Screening Assays	2017	Publication		Journal of Viral Hepatitis	Virology	M. Gencay, A. Seffner, S. Pabinger, J. Gautier, P. Gohl, M. Weizenegger, D. Neofytos, R. Batrla, A. Woeste, H. S. Kim, G. Westergaard, C. Reinsch, E. Brill, P. T. T. Thuy, B. H. Hoang, M. Sonderup, C. W. Spearman, G. Brancaccio, M. Fasano, G. B. Gaeta, T. Santantonio, W. E. Kaminski
Cell-Free DNA Analysis in Maternal Plasma in Cases of Fetal Abnormalities Detected on Ultrasound Examination	2015	Publication		The American College of Obstetricians and Gynecologists	Virology	Alexandra Benachi, MD, PhD, Alexandra Letourneau, MD, Pascale Kleinfinger, MD, Marie-Victoire Senat, MD, PhD, Evelyne Gautier, MD, Romain Favre, MD, PhD, Laurent Bidat, MD, Véronique Houfflin-Debarge, MD, PhD, Jean Bouyer, PhD, and Jean-Marc Costa, PharmD, for the Collaborative SEquençage a Haut Debit et Aneuploidies (SEHDA) Study Group
The Cobas Ampliprep/Cobas Taqman HCV Test, Version 2.0, Real-Time PCR Assay Accurately Quantifies Hepatitis C Virus Genotype 4 RNA	2013	Publication		Journal of Clinical Microbiology	Virology	Stéphane Chevaliez, Magali Bouvier-Alias Christophe Rodriguez, Alexandre Soulier, Jean-Dominique Poveda, Jean-Michel Pawlotsky
Global Age-Related Seroprevalence for Adeno-Associated Virus Serotype 9 Immunoglobulin G	2026	Presentation	WVCW		Virology	De Waal, L. Tacking tomorrow's threats: Innovation to address emerging pandemic potential influenza and re-emerging poliovirus. Presented at: World Vaccine Congress Washington (WVCW); Mar30-Apr2 2026; Washington DC, USA.
The Causes of Errors in Clinical Reasoning: Cognitive Biases, Knowledge Deficits, and Dual Process Thinking	2026	Poster	WRIB		Cross-therapeutic area	Martin Roberge, André Forté, Suzie Larocque, Chrystel Bertheau, Tran Nguyen, Cheryl Sabrina Yameogo, Mathieu Cloas, Mathilde Yu. Challenges surrounding 100% pre-exiting antibody incidence in matrices; tricks to develop/validate an anti-Ad5 vector TAb assay. Presented at: WRIB; April 13-17, 2026; Dallas, TX, USA.
Whole-genome Sequencing of Human Respiratory Syncytial Virus Using Oxford Nanopore Technology	2026	Poster	RSVVW		Virology	Anne Hout, Paul Reusink, Nikki Claasen, Lisette Dittmar-Rusman, Michiel Weber, Kalina Zlateva. Whole-genome sequencing of human respiratory syncytial virus using Oxford Nanopore technology. Presented at: RSVVW 2026; 17-20 february, 2026; Rome, Italy.
Scalable, Reliable Recovery of Intact DNA From Lymphodepleted Samples for CAR-T Vector Analysis	2026	Poster	ISCT		Hematological malignancies	JA Meyboom, S Ingelse, IH Wolters, K Devaraju. Scalable, Reliable Recovery of Intact DNA from Lymphodepleted Samples for CAR-T Vector Analysis. Presented at: International Society for Cell & Gene Therapy (ISCT) conference; May 6-9, 2026; Dublin, Ireland.
Navigating Viral Integration Landscapes with CRISPR-Cas9 and Long Read Sequencing	2026	Poster	ISCT		Virology	AJ Hout, N Claassen, IH Wolters, JFB Pagano, K Devaraju. Viral Integration Landscapes with CRISPR-Cas9 and Long-Read Sequencing. Presented at: International Society for Cell & Gene Therapy (ISCT) conference; May 6-9, 2026; Dublin, Ireland.
Validation of a Sequencing-Based HBV Genotyping Assay With Serological Backup for DNA-Suppressed Patients	2026	Poster	EASL		Virology	Sanne van Gils, Joël Meyboom, Bernhard Kleter. Validation of a sequencing-based HBV genotyping assay with serological backup for DNA-suppressed patients. Presented at: EASL; May 27–30, 2026; Barcelona, Spain.
Decoding CAR T Dynamics: Flow Cytometry–Driven Insights from Autologous and Allogeneic Trials	2026	Presentation	CYTO		Hematological malignancies	Nithianandan Selliah, Bieke Soen. Decoding CAR T Dynamics: Flow Cytometry–Driven Insights from Autologous and Allogeneic Trials. Presented at: CYTO; June 6-10, 2026; Florida, USA.
Analytical Validation of a 29-Color Spectral Flow Cytometry Panel for Broad Immunophenotyping and Functional Activity Assessment in Clinical Trials	2026	Poster	CYTO		Cross-therapeutic area	Christopher Rota, Manpreet Singh, Sanaz Koosha, Elaine Lourenco, Nithianandan Selliah. Analytical Validation of a 29-Color Spectral Flow Cytometry Panel for Broad Immunophenotyping and Functional Activity Assessment in Clinical Trials. Presented at: CYTO; June 6-10, 2026; Florida, USA.
Beyond Spectral Overlap: FRET-Driven Signal in TCR/CD3 Receptor Complex staining profile	2026	Poster	CYTO		Hematological malignancies	Sanaz Koosha, Manpreet Singh, Eva Van Lombergen, Bieke Soen, Matthias De Decker, Leen Catrysse, Nithianandan Selliah. Beyond Spectral Overlap: FRET-Driven Signal in TCR/CD3 Receptor Complex staining profile. Presented at: CYTO; June 6-10, 2026; Florida, USA.
Analytical Constraints of the Standard 6-Color TBNK Panel in Allogeneic CAR-T cell Trials and Strategies for Resolution	2026	Poster	CYTO		Hematological malignancies	Bieke Soen, Leen Catrysse, Eva Van Lombergen, Manpreet Singh, Nithianandan Selliah. Analytical Constraints of the Standard 6-Color TBNK Panel in Allogeneic CAR-T cell Trials and Strategies for Resolution. Presented at: CYTO; June 6-10, 2026; Florida, USA.
AI-Assisted Ki67 Evaluation in Solid Tumors: Consistency and Reliability Compared to Expert Pathologists	2026	Poster	AACR		Solid tumors	Rania Gaspo, Xavier Pichon, Maroua Tliba, Sabine Iglesias, Darshan Kumar, Renaud Burrer, Amanda Finan-Marchi, Marie Gérus-Durand. AI-Assisted Ki67 Evaluation in Solid Tumors: Consistency and Reliability Compared to Expert Pathologists. Presented at: AACR; Apr 17-22, 2026; San Diego, CA.
Immune Profiling and Targetable Biomarkers in NSCLC: Toward Rational Design of CKI-Based Combinations	2026	Poster	AACR		Solid tumors	Elena Baranova, Sabine Iglesias, Amanda Finan, Manon Motte, Renaud Burrer, Rania Gaspo, Marie Gérus-Durand. Multiplex Immunohistochemistry for Immuno-Oncology: A Flexible Approach to Characterize the Tumor Microenvironment. Presented at: AACR; Apr 17-22, 2026; San Diego, CA.
Integrating Immunohistochemistry for Biomarker Detection in NSCLC: A Step Toward Precision Therapy	2026	Poster	AACR		Solid tumors	R. Gaspo, A. Jean, R. Burrer, J. Sallette, A. Finan-Marchi, M. Gérus-Durand. Integrating Immunohistochemistry for Biomarker Detection in NSCLC: A Step Toward Precision Therapy. Presented at: AACR; Apr 17-22, 2026; San Diego, CA.
Multiplex IHC for Immuno-oncology: A Flexible Approach to Characterize the Tumor Microenvironment	2026	Poster	AACR		Solid tumors	R. Gaspo, A. Jean, R. Burrer, J. Sallette, A. Finan-Marchi, M. Gérus-Durand. Immune Profiling and Targetable Biomarkers in NSCLC: Toward Rational Design of CKI-Based Combinations. Presented at: AACR; Apr 17-22, 2026; San Diego, CA.
Highly Pathogenic Avian Influenza Virus A/H5N1 Subclade 2.3.4.4b Isolated From a European Grey Seal (Halichoerus Grypus) Is Highly Virulent in Ferrets	2025	Poster	WVCE		Virology	Kate Guilfoyle, Monica Mirolo, Leon de Waal, Geert van Amerongen, Guido van der Net, Theresa Störk, Mara Sophie Lombardo, Wolfgang Baumgärtner, Ásgeir Bjarnason, Hekla Bryndís Jóhannsdóttir, Guus Rimmelzwaan, Martin Ludlow, Albert Osterhaus. Highly Pathogenic Avian Influenza Virus A/H5N1 subclade 2.3.4.4b isolated from a European grey seal (Halichoerus grypus) is highly virulent in ferrets. Presented at: World Vaccine Congress Europe (WVCE), October 13-16, 2025, Amsterdam, The Netherlands.
Enhancing Breast Cancer Treatment Decisions with Artificial Intelligence: A Reliable Approach to Ki-67 Scoring	2025	Presentation	Biomarker and Precision Medicine		Solid tumors	Gérus-Durand M. Enhancing Breast Cancer Treatment Decisions with Artificial Intelligence: A Reliable Approach to Ki-67 Scoring. Presented at: Biomarker and Precision Medecine; October 27-28, 2025; San Francisco, US.
Qualification of Microneutralization Assays for HMPV and HPIV-3: Robust Tools for Clinical Vaccine Evaluation	2025	Poster	WVCE		Virology	A Tijsma, W van der Meide, M van Opstal, L Mastenbroek, E de Zeeuw, M Schelling, C van Baalen. Qualification of Microneutralization Assays for HMPV and HPIV-3: Robust Tools for Clinical Vaccine Evaluation. Presented at: World Vaccine Congress Europe (WVCE), October 13-16, 2025, Amsterdam, The Netherlands.
Safety Testing in Oncolytic Therapies by Monitoring Shedding and Replication Competency	2025	Poster	ESGCT		Solid tumors	IH Wolters, MC Boukes, S Ingelse, SV Gils, K Devaraju. Safety testing in oncolytic therapies by monitoring shedding and replication competency. Presented at: European Society of Gene & Cell Therapy (ESGCT); October 7-10, 2025; Sevilla, Spain.
Mitigation of the Presence of Crosstalk in an ADA Bridging Assay Using the MSD Platform for the Detection of Antibodies Against an Antibody-Drug Conjugate	2025	Poster	AAPS National Biotechnology		Cross-therapeutic area	Roberge M, Bélanger J, Forté A, Yu M. Mitigation of the presence of crosstalk in an ADA bridging assay using the MSD platform for the detection of antibodies against an antibody-drug conjugate. Presented at: AAPS National Biotechnology Conference; May 4-7, 2025; Boston, MA.
Tailoring Approaches to Mitigate the Presence of Pre-Existing Antibodies: Considerations for Different Assays Throughout the Immunogenicity Cascade Related to an ADC Drug Product	2025	Poster	WRIB		Cross-therapeutic area	Roberge M, Forté A, Bélanger J, Bergeron F, Yu M. Tailoring approaches to mitigate the presence of pre-existing antibodies: Considerations for different assays throughout the immunogenicity cascade related to an ADC drug product. Presented at: WRIB; April 7-11, 2025; New Orleans, USA.
Impact of Fixation/Permeabilization Buffers on Fluorescence Background and Marker Selection for Panel Design	2025	Poster	CYTO		Cross-therapeutic area	Koosha S, Singh M, De Decker M, Van Lombergen E, Njang Chia A, Catrysse L, Selliah N. Impact of Fixation/Permeabilization Buffers on Fluorescence Background and Marker Selection for Panel Design. Presented at: CYTO; May 31–June 4, 2025; Denver, Colorado.
Evaluating PBMC Usage in Clinical Trials: A Comparative Analysis of Cell Populations with Whole Blood in Cytek Aurora	2025	Poster	CYTO		Hematological malignancies	Baele A, Soen B, Rota C, Mehrzad S, Lourenco E, Catrysse L, Selliah N. Evaluating PBMC Usage in Clinical Trials: A Comparative Analysis of Cell Populations with Whole Blood in Cytek Aurora. Presented at: CYTO; May 31–June 4, 2025; Denver, Colorado.
Global Validation of a Flow Cytometry Panel for Clinical Trials: Detection of Ki67, Granzyme B and FoxP3 in T-, B- and NK Cell Populations	2025	Poster	CYTO		Hematological malignancies	Catrysse L, Nash V, De Decker M, Baele A, Singh M, Umulisa A, Koosha S, Mezue M, Selliah N. Global Validation of a Flow Cytometry Panel for Clinical Trials: Detection of Ki67, Granzyme B and FoxP3 in T-, B- and NK cell Populations. Presented at: CYTO; May 31–June 4, 2025; Denver, Colorado.
High Resolution Whole-Genome Sequencing of Human Metapneumovirus Using Oxford Nanopore Technology	2025	Poster	RSV Symposium		Virology	Zlateva K, Reusink P, Hout A, Dittmar-Rusman L, Weber L. High resolution whole-genome sequencing of human metapneumovirus using Oxford Nanopore technology. Presented at: 13th International RSV Symposium; March 12-15, 2025; Iguazu, Brazil.
Optimized Automated DNA Extraction: A Pathway to Improved Patient Monitoring in CAR-T Trials	2025	Poster	ASGCT		Hematological malignancies	Meyboom JA, Ingelse S, Wolters IH, Devaraju K. Optimized automated DNA extraction: A pathway to improved patient monitoring in CAR-T trials. Presented at: ASGCT 28th Annual Meeting; May 13-17, 2025; New Orleans, US.
HPV E4/p16INK4a Immunohistochemistry for the Prediction of CIN2 Regression - A Historical Cohort Study	2025	Poster	EBCOG		Solid tumors	Damgaard R, Jenkins D, Stoler MH, de Koning MNC, van de Sandt MM, Lycke KD, Kahlert J, Gravitt PE, Quint WGV, Steiniche T, Petersen LK, Hammer A. HPV E4/p16INK4a immunohistochemistry for the prediction of CIN2 regression - a historical cohort study. Presented at: 29th European Congress of Obstetrics and Gynaecology (EBCOG); June 5-7, 2025; Frankfurt, Germany.
Vulval Lichen Sclerosus and the Microbiome	2025	Poster	SID		Rare diseases	Spencer A, van den Munckhof E, Uthayakumar A, Jonkers J, Watchorn RE, Palmer EL, Akel R, de Koning MNC, Muneer A, Kravvas G, Fuller C, Lewis F, Bunker CB. Vulval lichen sclerosus and the microbiome. Presented at: Society of Investigative Dermatology (SID); May 7-10, 2025; San Diego, US.
Model Development of HPAI H5N1 Clade 2.3.4.4b in Naïve Ferrets	2025	Presentation	IfH		Virology	De Waal, L. Model development of HPAI H5N1 clade 2.3.4.4b in naïve ferrets. Presented at: Immunity for Health (IfH); October 1–2, 2025; Ghent, Belgium.
Cerba Research: The Netherlands	2024	Presentation	IVW		Virology	De Waal, L. Cerba Reserach The Netherlands. Presented at: Influenza Vaccines of the World (IVW); 21-23 May 2024; Siena, Italy.
Qualification of Microneutralization Assays for HMPV and HPIV-3: Robust Tools for Clinical Vaccine Evaluation	2024	Poster	WVCE		Virology	Tijsma, A., van der Meide, W., van Opstal, M., Mastenbroek, L., de Zeeuw, E., Schelling, M., van Baale, C. Qualification of Microneutralization Assays for HMPV and HPIV-3: Robust Tools for Clinical Vaccine Evaluation. Presented at: World Vaccine Congress Europe (WVCE); October 30, 2024; Barcelona, Spain.
Tailoring ADA and NAbAssays to Drug Modalities; Insights from Case Studies	2024	Presentation	IG Summit		Cross-therapeutic area	Roberge M. Tailoring ADA and NAb Assays to Drug Modalities: Insights from Case Studies. Presented at: Annual Immunogenicity & Bioassay Summit; Oct 15-18, 2024; Washington, DC, USA.
Development and Validation of an Assay to Assess Functional T-cell Responses using Intracellular Cytokine Staining and Flow Cytometry in Global Clinical Trials	2024	Poster	ICCS		Hematological malignancies	Rota, C., De Decker, M., De Baere, M., Catrysse,L., Selliah, N. Development and Validation of an Assay to Assess Functional T cell Responses using Intracellular Cytokine Staining and Flow Cytometry in Global Clinical Trials. Presented at ICCS 2024, Oct 4-8, 2024; Seattle, WA, USA.
Optimization, Validation and Implementation of a 25-color Flow Cytometry Assay on Cytek® Aurora Instrument to Monitor Immune Cells in Whole Blood for Multi-Location Clinical Trials	2024	Poster	ICCS		Hematological malignancies	Mehrzad, S., Spitaels, J., Singh, M.,Matisli, F., Baele, A., Soen, B., Catrysse, L., De Baere, M, Nash, V., Selliah, N. Optimization, Validation and Implementation of a 25-color Flow Cytometry Assay on Cytek® Aurora Instrument to Monitor Immune Cells in Whole Blood for Multi-Location Clinical Trials. Presented at ICCS 2024, Oct 4-8, 2024; Seattle, WA, USA.
Process Improvement in Clinical Sample Testing with Quality Checks and Efficient Workflow for Global Clinical Trials	2024	Poster	ICCS		Hematological malignancies	Singh, M., Waele, S., Meuze, M., Lourenço, E., Rota, C., Mehrzad, S., De Decker, M., Baele, A., Spitaels, J., De Baere, M., Nash, V., Selliah, N. Process Improvement in Clinical Sample Testing with Quality Checks and Efficient Workflow for Global Clinical trials. Presented at ICCS 2024, Oct 4-8, 2024; Seattle, WA, USA.
Monitoring Adenoviral Gene Therapy	2024	Poster	ESGCT		Rare diseases	VG Buyle, P Nuijten, S Ingelse, SV Gils, VC Jimenez, K Devaraju. Monitoring adenoviral gene therapy. Presented at: ESGCT Annual Congress; October 22-25, 2024; Rome, Italy.
Precision Mapping Viral Integration Landscapes with CRISPR-Cas9 and Long-Read Sequencing	2024	Poster	ESGCT		Virology	AJ Hout, VG Buyle, JFB Pagano, K Devaraju. Precision Mapping Viral Integration Landscapes with CRISPR-Cas9 and Long-Read Sequencing. Presented at: ESGCT Annual Congress; October 22-25, 2024; Rome, Italy.
Pandemic Preparedness: From Proof of Concept to Clinic	2024	Presentation	WVCW		Virology	De Waal L. Pandemic Preparedness: From Proof of Concept to Clinic. Presented at: World Vaccine Congress Washington (WVCW); 1-4 April 2024; Washington DC, USA.
Improved HBV-RNA Quantification by HBV-RNA Reverse Transcription Droplet Digital PCR	2024	Poster	EASL		Virology	Kleter B, van Gils S, Meyboom J, Verbinnen T, Lenz O, van Doorn L-J. Improved HBV-RNA quantification by HBV-RNA reverse transcription droplet digital PCR. Presented at: EASL congress; June 5-8, 2024; Milan, Italy. URL [https://www.easlcongress.eu/]
Utility of Artificial Intelligence (AI) in Ki67 Scoring of a Breast Cancer (BC) Patient Population	2024	Poster	ESMO		Solid tumors	Pichon X, Gaspo R, Kumar F, Rekinen S, Iglesias S, Burrer R, Finan A. Utility of artificial intelligence (AI) in Ki67 scoring of a breast cancer (BC) patient population. Presented at: ESMO annual meeting; September 13-17, 2024; Barcelona, Spain.
How Minor Blood Collection Differences Can Cause Major Issues for Bioanalytical Methods	2023	Poster	WRIB		Cross-therapeutic area	Martin Roberge, Sylvie Gélinas, Jennyfer Lacasse, Justine Bélanger, André Forté, Mathilde Yu. How minor blood collection differences can cause major issues for bioanalytical methods. Presented at: WRIB; June 19-23, 2023; Florida, USA.
Upscaling of a Clinical Flow Cytometry Laboratory	2023	Poster	ESCCA		Hematological malignancies	De Baere M, Spitaels J, Matisli F, Schelpe J, De Beuckelaer A, De Waele S, Selliah N. Upscaling of a clinical flow cytometry laboratory. Presented at: European Society for Clinical Cell Analysis (ESCCA); 27-30 September 2023; Utrecht, Netherlands. [https://escca.eu/education/escca-conferences]
Validation of a Flow Cytometry Assay on Cytek® Aurora Instrument to Monitor Immune Cells in Whole Blood for Clinical Trials	2023	Poster	ICCS		Hematological malignancies	Jan Spitaels, Feyzâ Matisli, Amber Baele, Leen Catrysse, Silke Waele, Miet De Baere, Veronica Nash and Nithianandan Selliah. Validation of a flow cytometry assay on Cytek® Aurora instrument to monitor immune cells in whole blood for clinical trials. Presented at: International Clinical Cytometry Society (ICCS); Sept 29-Oct 3, 2023; New Orleans, US. [https://www.cytometry.org/2023/]
Implementation of Cytek® Aurora Instrument for Global Clinical Trials	2023	Poster	ICCS		Hematological malignancies	Nash V, Spitaels J, Mehrzad S, Baele A, Schelpe J, De Waele S, De Baere M, Dankar A, Rentenaar C, Van Bockstael S, Selliah N. Implementation of Cytek® Aurora Instrument for Global Clinical Trials. Presented at: International Clinical Cytometry Society (ICCS); Sept 29-Oct 3, 2023; New Orleans, US. [https://www.cytometry.org/2023/]
Development and Validation of Flow Cytometry Assays for Autologous and Allogenic CAR T in Global Clinical Programs	2023	Poster	ESCCA		Hematological malignancies	Van Lombergen E, Soen B, Catrysse L, De Beuckelaer A, Selliah N. Development and Validation of Flow Cytometry Assay for Autologous and Allogenic CART trial. Presented at: European Society for Clinical Cell Analysis (ESCCA); 27-30 September 2023; Utrecht, Netherlands. [https://escca.eu/education/escca-conferences]
Implementing Cytek Aurora in Clinical Trials: Qualification & Standardization	2023	Poster	ESCCA		Hematological malignancies	Nash V, Spitaels J, Mehrzad S, Baele A, Schelpe J, De Waele S, De Baere M, Dankar A, Rentenaar C, Van Bockstael S, Selliah N. Implementation of Cytek® Aurora Instruments in Clinical Trials: A Multi-step Process Including Performance Qualification and Standardization. Presented at: European Society for Clinical Cell Analysis (ESCCA); 27-30 September 2023; Utrecht, Netherlands. [https://escca.eu/education/escca-conferences]
Validation of NanoString® Technologies for Solid Tumor Global Clinical Studies: Robustness, Precision and Inter-site Comparison	2023	Poster	SITC		Solid tumors	Promonet A, Stroili, A-R, Pichon X, Finan A. Validation of NanoString® technologies for solid tumor global clinical studies: Robustness, precision and inter-site comparison. Presented at: The Society for Immunotherapy of Cancer's (SITC); Nov 1-5, 2023; San Diego, USA. [https://www.sitcancer.org/events/event-description?CalendarEventKey=c25469b9-4e43-4126-a4a7-e193ab2797d7]
Comparison of BD FACSLyric™ Instrument Performance in a Global Setting	2023	Poster	ICCS		Hematological malignancies	Soen B, Schelpe J, De Baere M, Soosapilla A, Yeh E, Wei G, Nash V, Rota C, De Beuckelaer A, Selliah N. Comparison of BD FACSLyric™ instrument performance in a global setting. Presented at: ICCS; Sept 29-Oct 3, 2023; New Orleans, US. [https://www.cytometry.org/2023/]
Novel Image Analysis And IHC Advances For NASH	2023	Poster	EASL		Metabolic	Tilba M, Motte M, Sattonnet C, Lambarti VA, Baranova E, Gérus-Durand M, Burrer R, Finan A. Novel image analysis and immunohistochemistry advances to accompany pathologist driven NAFLD diagnosis. Presented at: EASL Congress; June 21-24, 2023; Vienna, Austria.
Workflow and Troubleshooting for Performance Qualification of Cytek Aurora Instrument in a Clinical Setting	2023	Poster	CYTO		Cross-therapeutic area	Nash V, Spitaels J, Mehrzad S, Baele A, Schelpe J, De Waele S, De Baere M, Miller B, Nguyen AT, Selliah N. Workflow and troubleshooting for Performance Qualification of Cytek Aurora instrument in a clinical setting. Presented at: CYTO; May 20-24, 2023; Montreal, Canada.
AI & Image Analysis for Ki-67 Quantification in Solid Tumors	2023	Poster	ESMO		Solid tumors	Pichon X, Gaspo R, Iglesias S, Kumar D, Tliba M, Burrer R, Finan A. Evidence for the utility of artificial intelligence (AI) and image analysis in Ki-67 quantification in solid tumors. Presented at: ESMO annual meeting; October 20-24, 2023; Madrid, Spain.
Comparison of BD FACSLyric™ Instrument Performance in a Global Setting	2023	Poster	CYTO		Hematological malignancies	Soen B, Schelpe J, De Baere M, Soosapilla A, Yeh E, Wei G, Nash V, Rota C, De Beuckelaer A, Selliah N. Comparison of BD FACSLyric™ instrument performance in a global setting. Presented at: CYTO; May 20-24, 2023; Montreal, Canada.
Translating Scientific Challenges into Preclinical Research Solutions	2023	Presentation	WVCW		Virology	Stadler K. Translating scientific challenges into preclinical research solutions. World Vaccine Congress Washington (WVCW); October 17-19, 2023; Barcelona, Spain.
Cytek® Aurora Instrument Standardization for Patient Testing in Global Clinical Trials	2023	Presentation	CYTEK		Hematological malignancies	Spitaels J, Nash V. Cytek Aurora instrument standardization for patient testing in global clinical trials. Presented at: Cytek User Group Meeting; June, 20-21, 2023; Amsterdam, Netherlands. [https://welcome.cytekbio.com/cytek-amsterdam-ugm-2023]
Immune Repertoire Profiling, a Window Into Tumor-Infiltrating Lymphocytes (TILs) Diversity	2023	Presentation	ASGCT		Hematological malignancies	Van Alewijk, D. Immune repertoire profiling, a window into tumor infiltrating lymphocytes (TILs) diversity. Presented at: 26th Annual Meeting ASGCT; May 16-20, 2023; Los Angeles, CA.
Optimized Automated DNA Extraction: A Pathway to Improved Patient Monitoring in CAR-T Trials	2023	Abstract	EHA		Hematological malignancies	Gaspo R, Claeys R, Sallette J. Minimal residual disease (MRD) detection trending as a primary endpoint in Cerba Research multiple myeloma (MM) trials. Presented at: EHA; June 8-11, 2023; Frankfurt, Germany.
Impact of Overfixation on Actionable Biomarkers and Checkpoint Inhibitor (CKI) Targets With Immunohistochemistry (IHC) in a Non-Small Cell Lung Cancer (NSCLC) Patient Population	2023	Abstract	ASCO		Hematological malignancies	Gérus-Durand M, Gaspo R, Jean A, Tsao M, Burrer R, Sallette J, Finan A. Impact of overfixation on actionable biomarkers and checkpoint inhibitor (CKI) targets with immunohistochemistry (IHC) in a non-small cell lung cancer (NSCLC) patient population. Presented at: ASCO annual meeting; June 2-6, 2023; Chicago, IL. [https://meetings.asco.org/abstracts-presentations/225029]
Analytical Validation of T-Regulatory IHC Multiplex in Solid Tumors	2022	Poster	AACR		Solid tumors	Gérus-Durand M, Baranova E, Tliba M, et al. Solid tumor analytical validation of a T-regulatory immunohistochemistry multiplex for clinical studies. presented at: AACR annual meeting 2022, New Orleans, Lousiana, April 8-13 [poster, https://doi.org/10.1158/1538-7445.AM2022-3871%5D
Multiplex Immunofluorescence Detects Resident Memory T Cells in Tumors	2020	Poster	AACR		Solid tumors	Baranova E, Finan A, Motte M, et al. Multiplex immunofluorescence detection of resident memory T cells in solid tumors. presented at: AACR annual conference 2020, San Diego, California, April 24-29 [poster, https://doi.org/10.1158/1538-7445.AM2020-4988%5D
In Situ Multiplex Analysis of Resident Microglia and Infiltrating Macrophages in Glioblastoma	2020	Poster	AACR		Solid tumors	Goulange N, Finan A, Tliba M, et al. In situ multiplex analysis of resident microglia and infiltrating macrophages in glioblastoma. presented at: AACR annual conference 2020, San Diego, California, April 24-29 [poster, https://doi.org/10.1158/1538-7445.AM2020-3323%5D
In Situ Multiplex Analysis of T Cells Across Multiple Tumor Types	2019	Poster	AACR		Solid tumors	Baranova E, Tliba M, Motte M, et al. In situ multiplex analysis of regulatory and effector T cells in multiple tumor types. presented at: AACR annual meeting 2019, Atlanta, Georgia, March 29-April 3 [poster, https://doi.org/10.1158/1538-7445.AM2019-4560%5D
Immune Checkpoint Profiling of Solid Tumors via Multiplex IF	2019	Poster	AACR		Solid tumors	Finan A, Goulange N, Motte M, et al. Immune cell checkpoint profiling of solid tumors by multiplex immunofluorescence. presented at: AACR annual meeting 2019, Atlanta, Georgia, March 29-April 3 [poster, https://doi.org/10.1158/1538-7445.AM2019-4116%5D
The Complexity of Myeloid-derived Suppressor Cells in Non-small Cell Lung Cancer: A Combinatorial Multiplex IHC and Flow Cytometry Approach	2019	Poster	SITC		Solid tumors	Finan A, Smet M, Tliba M, et al. The complexity of myeloid-derived suppressor cells in non-small cell lung cancer: A combinatorial multiplex IHC and flow cytometry approach. presented at: SITC annual meeting 2019; November 6-10, National Harbor, Maryland, Year. [Poster]
Obese Patients Carrying NAFLD Associated Genetic Variants Present Specific Serum And Liver Lipidomic Profiles Identification Of A Lipidomic Signature In Serum To Estimate The Liver Fat Content	2019	Abstract	AASLD		Metabolic	Alvaro Santos-Laso, Leyre Velaz, Cristina Alonso, Emma Eizaguirre, Ibon Martínez-Arranz, Maria Jesus Pareja, Ioana Riaño, Jesper Andersen, Enara Arretxe, Itziar Mincholé, Pablo Ortiz, Maria Jesus Perugorria, Ana Landa, Marcin Krawczyk, Frank Lammert, Rui Eduardo Castro, Patricia Aspichueta, Manuel Romero-Gomez, Luis Bujanda, Pedro Miguel Rodrigues and Jesus Banales
Assessing MM Response with Daratumumab IFE Reflect Assay (DIRA)	2015	Poster	ASCO		Hematological malignancies	Christopher McCudden, Amy Axel, Dominique Slaets, Sandy Frans, Jaime Bald, Jordan Schecter, Tahamtan Ahmadi, Torben Plesner, Kate Sasser. Assessing Clinical Response in Multiple Myeloma (MM) Patients Treated With Monoclonal Antibodies (Mabs): Validation of a Daratumumab IFE Reflex Assay (DIRA) to Distinguish Malignant M-Protein From Therapeutic Antibody. Presented at: ASCO annual meeting; May 29-June2, 2015; Chicago, IL.

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