The rapid rise of precision medicine is driving major innovations in histopathology. The synergy between increasingly sophisticated specialty services and evolving techniques in digital imaging yields opportunities for emerging companion diagnostics.

Cerba Research has invested in innovation through a fully equipped histopathology laboratory. We offer:

  • Tissue processing
  • Tissue embedding and sectioning
  • Standard and special stains
  • Immunohistochemical staining (IHC)
  • Multiplex IHC with up to 8 biomarkers per slide
  • Cytology
  • Tissue cross-reactivity assays
  • Companion diagnostic development
  • Digital imaging analysis

Working shoulder to shoulder with our experts, our clients can access the most extensive array of technology platforms to enhance drug development. Through worldwide pathologist review and the latest digitization and AI analysis, we consistently meet client specifications.

Access more information per sample through immunohistochemistry

To spare your precious samples, unleash biomarker information by measuring up to eight biomarkers on a single slide. Identify disease subtypes, validate targets, select patients, and characterize efficacy and response through immunohistochemical testing.  

For extra value, Cerba Research delivers:

An integrated workflow incorporating:

  • A global network of expert pathologists
  • Digital pathology, through automated acquisition
  • Determination of area of interest

Enhanced software image analysis facilitating:

  • Biomarker quantification
  • Co-expression of biomarkers
  • Segmentation of specific tissue types, supported by trainable algorithms
  • Multispectral scanning and imaging solutions that provide information from FFPE tissue, cryosections, or tissue microarrays (TMAs)

Design-your-own multiplex labeling strategies with:

  • More than 150 validated markers
  • Rigorous multiplex validation

State-of-the-art technology for IHC

  • PerkinElmer Vectra® Polaris™
  • Roche DISCOVERY
  • Leica BOND RX
  • Ventana Discovery XT
  • Ventana BenchMark
  • Hamamatsu NanoZoomer

Histopathology tools

Special Stains
  • Alcian Blue
  • Alcian Blue/Periodic Acid-Schiff (PAS)
  • Alizarin Red
  • Azan Mallory
  • Calleja
  • Giemsa
  • Gomori’s Elastin Trichrome
  • Gram
  • Hematoxylin Eosin (HE)
  • HE/Alcian Blue
  • Hematoxylin Eosin Saffron (HES)
  • Kluver-Barrera (Luxol Fast Blue)
  • Masson’s Trichrome
  • Movat Pentachrome
  • Oil Red O/Hematoxylin
  • Orcein
  • PAS
  • Sirius Red
  • Toluidine Blue
  • Von Kossa

Immunohistochemistry Antibodies
  • 5T4
  • AGR2
  • AR
  • β-amyloid
  • β-galactosidase
  • Beta integrin 1
  • BCL2
  • BCLXL
  • BCM
  • CA 19-9
  • Caspase 3
  • Cathepsin beta
  • CC-10
  • CCR7
  • CD3
  • CD4
  • CD8
  • CD11b
  • CD11c
  • CD15
  • CD16
  • CD19
  • CD20
  • CD31
  • CD39
  • CD45
  • CD45RA
  • CD45RO
  • CD47
  • CD57
  • CD62L
  • CD68
  • CD73
  • CD94
  • CD144-Cadherin 5
  • CD155
  • CD163
  • CD226
  • CEA
  • CK3
  • CK5/CK6
  • CK20
  • C-Met
  • Collagen IV
  • Connexin 43
  • CTLA4
  • Cystatin
  • DDR1
  • Dystrophine
  • Elastine
  • Endocan
  • ER (Estrogen Receptor)
  • F4/80
  • FAM (FITC) with chromogen for fluo application
  • FcGRT
  • FcRN
  • Fibrinogen
  • Fibroblast
  • Fibronectin
  • Filaggrin
  • Fox J1
  • Foxp3
  • GD2
  • GFAP
  • GFP
  • Glucagon
  • Glucagon/Insuline
  • H.Pylori
  • HER2
  • HLA
  • HLA-E
  • HLA-G
  • hTERT
  • Human IgG
  • Human Endocan
  • IDH-1
  • IgG1
  • IFN gamma
  • IL-1α
  • IL-1β
  • IL-1 RAcP
  • iNOS
  • Insulin
  • Integrin β3
  • Kappa
  • Ki67
  • Lambda
  • Laminin
  • Langerin
  • LC3B
  • LDH
  • Lox-1
  • MAC387 (anti-macrophage)
  • macroH2A1.1
  • MAP2
  • MCL1
  • MelanA
  • MHC II
  • MICA/B
  • MRP8 & 14 Macrophage
  • MUC2
  • Na/K ATPase
  • Nectin-1
  • NKp46
  • OAcGD2
  • Occludin
  • OX-40
  • p16
  • p40
  • p53
  • p63
  • pAKt
  • PanKeratin
  • PCNA
  • PD-1
  • PD-L1
  • pEGFR
  • pH2AX
  • PLA2G1B
  • Plakoglobin
  • p-Met
  • PR (progesterone receptor)
  • PSMA
  • pTau
  • S100
  • SCN5A
  • SIRPa
  • SLC1A5
  • α-SMA
  • Spectrin
  • SYD1594-FITC
  • Synaptophysin
  • TAU
  • TIGIT
  • TLR-3
  • TNF-α
  • TNFRSF14/HVEM
  • Trypanosome cruzy
  • Tyrosine hydroxylase
  • Vaccinia virus
  • VCAM1
  • VEGRF2
  • Vimentin
  • Wheat Germ Agglutinin
Multiplex Panels
  • Multiplex CD11b/CD14/CD66b/HLADR/Arg1/iNOS
  • Multiplex CD11b/CD68/CD163/HLADR/Arg1/iNOS
  • Multiplex CD47/CD163/Mesothelin/CD11b/CD8/CD3
  • Multiplex CD8/PD/L1/PD/1/CD3
  • Multiplex overview CD3/CD4/CD8/CD56/CD68/CD20
  • Multiplex p63/CK5/6/TTF-1/Napsin A
  • Multiplex Tregs
  • Multiplex CD3/CD4/CD8/Foxp3/CD20/Vimentine
  • Multiplex HER2/CD8/PD-1/Cytokeratin
  • Multiplex IL-1/RAcp/CD11b/PD-L1/CD68/CD8/Foxp3
  • Multiplex SIRPa/CD11b/CD163/CD47