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Applying In Situ Hybridization and Multiplex Analysis with Spatial Precision

Make sense of complex biology with high‑plex, spatially resolved technologies, expert scientific partnership, and globally harmonized delivery.

Turning spatial complexity into actionable biological insight

Biological signals rarely exist in isolation. When biomarkers are distributed across different cells and tissue regions, analyzing them separately can hide how they relate contextually.

In situ hybridization (ISH) and multiplex technologies help you detect multiple RNA, DNA, and protein targets within intact tissue, revealing exactly where they sit and how they interact at the cellular level.

Our scientific teams work alongside you from early assay design and optimization through clinical trial delivery, selecting and applying the spatial methods that match your study objectives, not a one-size-fits-all package.

This context gives you a fuller picture of disease biology and treatment response, surfacing patterns that individual analysis misses. Combined with our harmonized workflows across labs and regions, that context becomes reproducible, spatially resolved data built to stand up to scrutiny and move your research forward.

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Expertise built for high-dimensional tissue analysis

Advanced spatial and high-plex technologies

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  • NanoString®  gene expression and spatial profiling platforms
  • RNAscope® ISH technology spatial genomics and transcriptomics tool
  • High-plex multiplex analysis within a single tissue sample
  • Sensitive detection of RNA and DNA targets

Integrated biomarker insights

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  • Combination of ISH, multiplex, and histopathology workflows
  • Multi-modal data generation from tissue, molecular, and imaging platforms
  • Deeper biological insight through spatial context

Agile global delivery model

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  • Harmonized laboratories with standardized workflows
  • Consistent data quality across regions and study phases
  • Scalable support for multi-site clinical trials

Expert-led assay strategy

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  • Fit-for-purpose assay design aligned to study endpoints
  • Development, optimization, and validation support
  • Scientific partnership from early development through clinical trials

Comprehensive in situ hybridization and multiplex capabilities

Technology spotlight: RNAscope® ISH

High-sensitivity spatial gene expression analysis at single-cell resolution

Our tissue analysis laboratory in Montpellier, France, is a certified RNAscope® service provider through the Advanced Cell Diagnostics (ACDbio) program. This ensures consistent delivery of high-quality, reproducible in situ hybridization data aligned with rigorous industry standards.

Why RNAscope® matters for your program

RNAscope® enables precise detection and localization of RNA targets within intact tissue, combining sensitivity with spatial accuracy. This allows you to:

  • Detect RNA targets at single-cell resolution
  • Preserve spatial relationships within tissue architecture
  • Achieve high specificity with low background signal
  • Generate reliable data across complex tissue types

By linking gene expression directly to spatial context, RNAscope® provides a deeper understanding of biological mechanisms than traditional gene expression approaches.

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Bring spatial insight into your next study

Design and deliver in situ hybridization and multiplex strategies with expert scientific support, tailored to the needs of your program. Connect with our teams to get started.

Multiplex and hybridization imaging FAQs