North America (New York, San Diego, Richmond) – Central America (Mexico, Costa Rica) – Latin America (Argentina, Chili, Peru, Brazil, Colombia) – Europe (Belgium, Netherlands, UK, Serbia, Turkey, Spain, Ukraine) – Africa (South Africa, Kenya) – Asian Pacific (South Korea, Philippines, Japan, India, Australia, Israel, China)
Our PBMC Processing Services
Joined together, our capabilities and expertise guarantee customers a high level of quality from sample collection to processing, shipping, handling, storage and analysis worldwide.
The usefulness and efficiency of PBMC studies should not be overlooked. The increased use of these immune mononuclear cells as a promising indicator of drug efficacy in clinical trials, as well as the increased convenience of working with samples versus conducting testing, makes PBMCs crucial. At Cerba Research, we embrace the potential of PBMC activities to maximize impact in clinical research.
To keep up with rising clinical research demand, we perform various PBMC activities like isolation from whole blood samples and DNA extraction using advanced technologies and equipment.
- PBMC isolation on a global scale
- Harmonized SOP/QC and instrumentation
- Utilize density grade centrifugation (DCG) with CPT® tubes
- For use in immunology, infectious disease, hematological malignancies, vaccine development, transplant therapy, personalized medicine, cell & gene therapy and toxicology
Brochure – What Are The Main Challenges And Questions To Overcome With PBMCs?
There are important questions you need to ask yourself and any potential laboratory partner before you start a study including PBMC assays as part of your protocol :
- What PBMC methodology best fits your intended outcome and study?
- Where do you want to run your study and at what scale?
- What data are you looking to generate from your PBMC?
Your partner PBMC laboratory needs to be able to support you with their answers to all these challenges. Download our free brochure and discover how Cerba Research can help you answer these questions and help provide you with a global solution for all your PBMC needs.
Harmonized SOPs on a global scale for PBMCs isolation, cryopreservation and storage, ensuring high viability and recovery.
Viability ≥ 97%
Post collection using CPTtubes, the average viability obtained is 99.3% after 4 hours, 97,9% after 24, and 96.8% and 85.5% respectively post-thawing.
Recovery ≥ 75%
After thawing, the average recovery is 75%.
- Management of sample processing labs
- PBMC personal training program and certification
- Custom sampling kits preparation
- Sample tracking and tracing (e.g. guaranteeing a temperature-controlled supply chain and online-sample timeline)
- Premium courier transportation in accordance with ADR & IATA regulations
- All our pre-processing labs are accredited to the relevant local laboratory accreditation standards, which include: CAP, GCP, GLP, ISO17025/15189
- Quality control and personnel training is monitored on-site to ensure compliance with the processing procedures required by the customer
- 45+ processing labs in America, Europe, Africa, Asia, and Australia
- Ability to on-board lab partners worldwide
- PBMC isolation in 25+ countries
- Our standard PBMC processing protocol includes Vacutainer® CPT Mononuclear Cell Preparation Tube
- Customized upon request
- Short turnaround times
- Same-day PBMC isolation
Turnaround times may vary from one country to another, reflecting possible transportation delays or excessive workloads within the lab
Belgium (Ghent)
Routine, Molecular Biology,
Bioanalytical Lab, Flow
Cytometry, Microbiology
Industriepark-Zwijnaarde 3,
9052, Belgium
- Office number: +32 94 96 80 28
- Direct line: +32 94 96 82 19
France (Paris & Montpellier)
Genetics/NGS, Molecular Biology,
IVD, Flow Cytometry,
Histopathology/
IHC, Virology, Biorepository, BSL3
Paris:
Zac des Epineaux 10 Avenue Rolland Moreno CS 51312 95740, FREPILLON, France
Quality Charter
Montpellier:
126 Rue Emile Baudot,
34000, France
South Africa (Johannesburg)
Routine, Genetics/NGS, Molecular
Biology, Virology, Microbiology,
BSL3, Biorepository
China (Shanghai)
Routine, Genetics/NGS, Molecular Biology,
Flow Cytometry,
Bioanalytical Lab/PK,
Histopathology/IHC
Taiwan (Taipei)
Routine, Genetics/NGS, Flow
Cytometry, Histopathology/IHC Lab,
Sydney (Australia)
Routine, Molecular Biology,
Flow Cytometry, Virology
Tokyo (Japan)
Shinjuku I-Land-Tower 10F
6-5-1, Nishishinjuku, shinjuku-ku
163-1310, Japan
The Netherlands
BSL3, Pre-clinical, Molecular
Biology, Genetics/NGS,
Pathology, Virology
Rotterdam:
Rotterdam Science Tower
Marconistraat 16
3029 AK, The Netherlands
Rijswijk:
Visseringlaan 25
2288 ER, The Netherlands
Schaijk:
Nistelrooise Baan 3
5374 RE, The Netherlands
New York (North America)
10 Nevada Drive
Lake Success, NY 11042, USA
Routine, Genetics/NGS,
Molecular Biology, IVD, Flow
Cytometry, Bioanalytical Lab/PK,
Histopathology/IHC, Virology
Montreal (North America)
3150 Rue Delaunay
Laval, QC, Canada, H7L 5E1
Routine, Genetics/NGS,
Molecular Biology, IVD, Flow
Cytometry, Bioanalytical Lab/PK,
Histopathology/IHC, Virology
Cape Town
Birkdale building 2
Riverpark Business Park
Mowbray, South Africa
Durban
95 King Cetshwayo Highway
Block A, 2nd Floor Westridge
4001, South Africa
The isolation separates PBMCs from other components in the blood, enabling their use in research. PBMCs are part of a network of cells responsible for immune response against pathogens and cancerous cells.
ELISpot, FluoroSpot and Flow cytometry assays are commonly used to assess cellular immunogenicity at a single-cell level by measuring a PBMC sample’s ability to produce and secrete cytokines in response to antigen stimulation.
PBMCs are isolated from freshly collected blood. Depending on the quality (viability, recovery) of PBMC required for downstream analysis, the TAT between fresh blood sample collection and PBMC isolation may vary greatly. In recent years downstream analysis often requires rapid PBMC isolation, such as within 8-10 hours.
To perform PBMC isolation within a short timeframe (e.g., <8 hours), the PBMC processing laboratory must be closely located (in a driving distance) to the Clinical site. This can be achieved by two ways:
Local PBMC processing labs are selected, trained, and qualified for the task
As an exception: Clinical sites are trained to perform the PBMC isolation
Cerba Research will require anywhere between 2-6 months to qualify a new PBMC processing laboratory. Depending on the PBMC isolation protocol, location, specific requirements. The lead time to qualify a lab that is already identified and operational in our network can be significantly less.
Yes, we can train and qualify the local PBMC processing labs to match the relevant Sponsor requirements.
Yes, Cerba Research has experience in both pre-analytical and analytical services. We can ensure proper PBMC collection to combine with high-quality specialty testing. This allows us to have full control over the quality of services from collection until result reporting.
Reach out to our experts and discover how we can help you transform research and advance health
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