Human respiratory syncytial virus (HRSV) is a leading cause of severe lower respiratory illness in young children and the elderly. HRSV is classified within the Orthopneumovirus genus of the Pneumoviridae family and is divided in two major antigenic groups HRSV-A and HRSV-B. Based on whole-genome phylogeny and signature amino acids, HRSV sequences are currently classified into 24 HRSV-A and 16 HRSV-B lineages.
Accurate and rapid characterization of HRSV genomes is essential for large-scale genomic surveillance and monitoring drug resistance mutations associated with novel antiviral therapies.
In this poster we show HRSV-A/B WGS assays demonstrate robust performance and high sensitivity, suitable to be applied directly on respiratory samples for large-scale viral genomic surveillance studies and investigating drug resistance mutations of new antiviral therapies.
