- Innovation in antiviral development
One of the most prominent themes at this year’s meeting was progress in antiviral development.
A long-standing challenge in RSV treatment has been timing. Many antivirals are most effective when administered early in infection, making diagnosis and intervention speed critical. Encouragingly, new molecules currently under development are showing promising results, including improved effectiveness even when administered later in infection.
Innovation is also extending to delivery methods, with exploration of non-intravenous formats such as spray-based therapies. Alongside this, monitoring drug resistance remains an important focus area, reinforcing the growing role of molecular tools in supporting treatment strategies.
- Vaccines, maternal immunization and public perception
While several RSV vaccines are now licensed for adult populations, protecting infants remains a key area of attention.
Discussions at RSVVW covered maternal immunization strategies, passive immunization using monoclonal antibodies, and broader considerations around vaccine implementation. Public perception and vaccine confidence, particularly in the post-COVID environment, were also explored.
One particularly insightful session presented questionnaire data from young mothers, suggesting that some may feel more comfortable receiving vaccination during pregnancy rather than having their infants vaccinated directly.
While vaccines remain central, there may be a growing shift in industry focus toward next-generation therapeutics, particularly considering vaccine hesitancy trends.
- An expanding treatment landscape
For many years, RSV lacked approved therapeutic options. Today, the landscape is rapidly evolving. Current developments include:
- Licensed vaccines for adults
- Maternal vaccination approaches
- Monoclonal antibody options for infants
- Antivirals progressing through development.
While there is unlikely to be a single universal solution, the breadth of innovation signals meaningful progress. Importantly, many of the scientific and technological advances emerging from RSV research may also inform approaches to other viral diseases in the future.