SARS-CoV-2 ELISpot: a New Test in the COVID-19 Diagnostic and Vaccine Arsenal
What is an ELISpot Assay?
The assay consists of measuring the specific cellular response against more than 250 peptides of the SARS-CoV-2 Spike (S) and Nucleocapsid (N) proteins by quantifying the number of interferon-producing T cells. The lymphocytes of ill or vaccinated patients are isolated and then brought into contact with the virus antigens. After 20 hours of incubation, the production of interferon is measured. A positive assay allows differentiating the immunity related to infection with the virus (testing positive for anti-SARS-CoV-2 S-protein and N-protein antibodies) from the immunity related to vaccination (testing positive only for anti-SARS-CoV-2 S-protein antibodies).
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Immunohistochemistry (IHC): Increase the Success of Biomarker Integration in Clinical Development
“With immunohistochemistry (IHC) technology, biomarkers can be identified in tumor biopsies. IHC provides the possibility to better understand biomarker mechanisms in the tumor’s environment. By implementing a robust biomarker validation process, you can increase the success of biomarker integration in clinical development.”
– Amanda Finan, PhD, Head IHC/Histology R&D and Clinical Validations at Cerba Research
HISTOSELECT: How to Overcome Challenges in Antibody Selection?
HISTOSELECT®: The number one solution for direct screening of large numbers of antibodies by immunohistochemistry (IHC).